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EP 4 168 552 A1

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(43) Date of publication: 26.04.2023 Bulletin 2023/17 (21) Application number: 21826483.6 (22) Date of filing: 18.06.2021

(51) International Patent Classification (IPC):  C12N 15/50(2006.01) A61K 39/215(2006.01) C07K 14/165(2006.01) A61P 31/14(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/14; C07K 14/005; C12N 2770/20034; C12N 2770/20022; A61K 39/12; A61K 2039/55505; A61K 2039/55561 (86) International application number: PCT/CN2021/100826 (87) International publication number: WO 2021/254473 (23.12.2021 Gazette 2021/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 18.06.2020 US 202063040696 P 01.03.2021 WO PCT/US2021/020277 (71) Applicants: Medigen Vaccine Biologics Corporation Zhubei City, Taiwan 302 (TW) Dynavax Technologies Corporation Emeryville, CA 94608 (US)

(72) Inventors: KUO, Tsun-Yung Lan County, Taiwan 26341 (TW) CHEN, Charles Taipei City, Taiwan 11493 (TW) WU, Chung-Chin Lan County, Taiwan 26846 (TW) LIN, Yi-Jiun Taipei City, Taiwan 11493 (TW) LIN, Meei-Yun Taipei City, Taiwan 11493 (TW) WU, Yu-Chi Taipei City, Taiwan 11493 (TW) CAMPBELL, John, D. Emeryville, California 94608 (US) JANSSEN, Robert, S. Emeryville, California 94608 (US) NOVACK, David Emeryville, California 94608 (US) COFFMANN, Robert Emeryville, CA 94608 (US) TRAQUINA, Paula Emeryville, CA 94608 (US) (74) Representative: Wittmann, Günther  Patentanwaltskanzlei Wittmann Frans-Hals-Straße 31 81479 München 81479 München (DE)