| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
10.07.2020 GB 202010620
|
| (43) |
Date of publication of application: |
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17.05.2023 Bulletin 2023/20 |
| (73) |
Proprietor: GTInvent Limited |
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Aberdeen Scotland AB24 5RP (GB) |
|
| (72) |
Inventors: |
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- POLLACK, Saskia, Julie
Brighton BN1 9QG (GB)
- MARSHALL, Karen, Elizabeth
Brighton BN1 9QG (GB)
- SERPELL, Louise, Charlotte
Brighton BN1 9QG (GB)
- WISCHIK, Claude, Michel
Aberdeen AB24 5RP (GB)
- HARRINGTON, Charles, Robert
Aberdeen Aberdeen AB25 2ZD (GB)
|
| (74) |
Representative: Nick, Amy Sarah et al |
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Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL
London WC1X 8NL (GB) |
| (56) |
References cited: :
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- CHARLES R. HARRINGTON ET AL: "Cellular Models of Aggregation-dependent Template-directed
Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer
Disease", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, no. 17, 10 March 2015 (2015-03-10),
US, pages 10862 - 10875, XP055727618, ISSN: 0021-9258, DOI: 10.1074/jbc.M114.616029
- AL-HILALY YOUSSRA K ET AL: "Alzheimer's Disease-like Paired Helical Filament Assembly
from Truncated Tau Protein Is Independent of Disulfide Crosslinking", JOURNAL OF MOLECULAR
BIOLOGY, vol. 429, no. 23, 15 September 2017 (2017-09-15), pages 3650 - 3665, XP085262223,
ISSN: 0022-2836, DOI: 10.1016/J.JMB.2017.09.007
- AL-HILALY YOUSSRA K. ET AL: "Tau (297-391) forms filaments that structurally mimic
the core of paired helical filaments in Alzheimer's disease brain", FEBS LETTERS,
vol. 594, no. 5, 1 December 2019 (2019-12-01), NL, pages 944 - 950, XP055848181, ISSN:
0014-5793, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1002/1873-3468.13675>
DOI: 10.1002/1873-3468.13675
- POLLACK SASKIA J ET AL: "Paired Helical Filament-Forming Region of Tau (297-391) Influences
Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells",
JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 432, no. 17, 16
July 2020 (2020-07-16), pages 4891 - 4907, XP086238050, ISSN: 0022-2836, [retrieved
on 20200716], DOI: 10.1016/J.JMB.2020.05.027
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