(19)

(11)

EP 4 181 911 A1

(12)

(43) Date of publication: 24.05.2023 Bulletin 2023/21 (21) Application number: 21745316.6 (22) Date of filing: 14.07.2021

(51) International Patent Classification (IPC):  A61K 31/192(2006.01) A61K 31/40(2006.01) G01N 33/574(2006.01) G01N 33/68(2006.01) A61K 31/194(2006.01) A61P 35/00(2006.01) C12Q 1/6886(2018.01) (52) Cooperative Patent Classification (CPC): A61K 31/192; A61K 31/194; A61K 31/40; A61P 35/00; G01N 33/57492; G01N 33/6872; G01N 2800/52; C12Q 1/6886; C12Q 2600/118; C12Q 2600/158 (86) International application number: PCT/EP2021/069614 (87) International publication number: WO 2022/013295 (20.01.2022 Gazette 2022/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.07.2020 EP 20185777 (71) Applicants: Universitätsklinikum Regensburg 93053 Regensburg (DE) Universität Regensburg 93053 Regensburg (DE)

(72) Inventors: HAFERKAMP, Sebastian 93049 Regensburg (DE) ADAMSKI, Jerzy 80809 München (DE) GEISSLER, Edward 93173 Wenzenbach (DE) MYCIELSKA, Maria 93051 Regensburg (DE) FEDERLIN, Marianne 93080 Pentling (DE) MILENKOVIC, Vladimir 93096 Köfering (DE) GAUMANN, Andreas 87600 Kaufbeuren (DE) ZIEGLER, Christine 63128 Dietzenbach (DE) MADEJ, M. Gregor 91049 Regensburg (DE) (74) Representative: Engelhard, Markus  Boehmert & Boehmert Anwaltspartnerschaft mbB Pettenkoferstrasse 22 80336 München 80336 München (DE)