(19)

(11)

EP 4 182 429 A1

(12)

(43) Date of publication: 24.05.2023 Bulletin 2023/21 (21) Application number: 21841758.2 (22) Date of filing: 19.07.2021

(51) International Patent Classification (IPC):  C12M 1/00(2006.01) C12M 1/34(2006.01) C12M 1/32(2006.01) C12M 3/00(2006.01) (52) Cooperative Patent Classification (CPC): C12M 23/40; C12M 29/00 (86) International application number: PCT/US2021/042179 (87) International publication number: WO 2022/016143 (20.01.2022 Gazette 2022/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 17.07.2020 US 202063053388 P 19.01.2021 US 202163139138 P 19.03.2021 US 202163163160 P (71) Applicant: Vanderbilt University Nashville, TN 37240 (US)	(72) Inventors: REISERER, Ronald S. Nashville, TN 37217 (US) WIKSWO, John P. Brentwood, TN 37027 (US) (74) Representative: Weickmann & Weickmann PartmbB  Postfach 860 820 81635 München 81635 München (DE)