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(11)

EP 4 182 445 A2

(12)

(88) Date of publication A3: 24.02.2022 (43) Date of publication: 24.05.2023 Bulletin 2023/21 (21) Application number: 21842986.8 (22) Date of filing: 19.07.2021

(51) International Patent Classification (IPC):  C12N 5/078(2010.01) C12N 9/22(2006.01) A61P 7/06(2006.01) C12N 15/113(2010.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/4703; C07K 16/2818 (86) International application number: PCT/US2021/042152 (87) International publication number: WO 2022/016140 (20.01.2022 Gazette 2022/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 17.07.2020 US 202063053308 P 20.08.2020 US 202063068150 P (71) Applicant: The Children's Medical Center Corporation Boston, MA 02115 (US)	(72) Inventors: BAUER, Daniel, E. Cambridge, MA 02138 (US) VINJAMUR, Divya Boston, MA 02115 (US) (74) Representative: Dolphin, Kirsty Mairi et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)