(19)

(11)

EP 4 185 278 A1

(12)

(43) Date of publication: 31.05.2023 Bulletin 2023/22 (21) Application number: 21845536.8 (22) Date of filing: 20.07.2021

(51) International Patent Classification (IPC):  A61K 9/70(2006.01) A61K 31/192(2006.01) A61K 33/38(2006.01) A61L 15/44(2006.01) A61P 17/02(2006.01) C07C 39/19(2006.01) C07C 65/19(2006.01) A61K 31/05(2006.01) A61K 31/352(2006.01) A61K 36/185(2006.01) A61L 29/16(2006.01) A61P 31/04(2006.01) C07C 39/23(2006.01) C07D 311/58(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/05; A61K 31/192; A61K 31/352; A61K 33/38; A61K 36/185; A61L 15/44; A61L 29/16; A61P 17/02; A61P 31/04; A61L 2300/406; A61L 2300/104; A61L 29/085; A61L 29/145; A61L 15/60; A61K 9/7007; Y02A 50/30   C-Sets: A61K 31/352, A61K 2300/00; A61L 29/085, C08L 29/04; A61K 33/38, A61K 2300/00; A61K 31/05, A61K 2300/00; A61K 31/192, A61K 2300/00; (86) International application number: PCT/CA2021/051005 (87) International publication number: WO 2022/016269 (27.01.2022 Gazette 2022/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 22.07.2020 US 202063055211 P 10.11.2020 US 202063111972 P (71) Applicant: The University of British Columbia Vancouver, British Columbia V6T 1Z3 (CA)	(72) Inventors: JACKSON, John K. Vancouver, British Columbia V7W 2H4 (CA) THOMPSON, Charles J. Vancouver, British Columbia V6K 1C1 (CA) LAMBERT, Dana M. Vancouver, British Columbia V7W 2H7 (CA) DOSANJH, Manisha Surrey, British Columbia V3X 1S9 (CA) (74) Representative: De Clercq & Partners  Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem 9830 Sint-Martens-Latem (BE)