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(11)

EP 4 185 584 A1

(12)

(43) Date of publication: 31.05.2023 Bulletin 2023/22 (21) Application number: 21847228.0 (22) Date of filing: 23.07.2021

(51) International Patent Classification (IPC):  C07D 409/04(2006.01) A61P 3/10(2006.01) A61K 31/445(2006.01) C07D 409/14(2006.01) A61P 35/00(2006.01) A61K 31/513(2006.01) (52) Cooperative Patent Classification (CPC): A61P 3/10; A61P 35/00; C07D 409/04; C07D 409/14; A61K 45/06 (86) International application number: PCT/US2021/043007 (87) International publication number: WO 2022/020738 (27.01.2022 Gazette 2022/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 24.07.2020 US 202063056413 P (71) Applicant: Capulus Therapeutics, LLC San Francisco CA 94105 (US)	(72) Inventors: GREEN, Michael John Half Moon Bay, California 94019 (US) HART, Barry, Patrick San Francisco, California 94105 (US) (74) Representative: Cooley (UK) LLP  22 Bishopsgate London EC2N 4BQ London EC2N 4BQ (GB)