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(11)

EP 4 185 870 A1

(12)

(43) Date of publication: 31.05.2023 Bulletin 2023/22 (21) Application number: 21755647.1 (22) Date of filing: 23.07.2021

(51) International Patent Classification (IPC):  G01N 33/569(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/56972; G01N 2333/70535; G01N 2333/70553; G01N 2333/70596 (86) International application number: PCT/US2021/043067 (87) International publication number: WO 2022/020774 (27.01.2022 Gazette 2022/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 24.07.2020 US 202063056504 P (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: HIDALGO ROBERT, Alberto Jose South San Francisco, California 94080-4990 (US) GREEN, Cherie Louise South San Francisco, California 94080-4990 (US) TOGHI ESHGHI, Shadi South San Francisco, California 94080-4990 (US) ORLOVA, Darya Yuryevna South San Francisco, California 94080-4990 (US) (74) Representative: Küng, Peter  F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)