(19)

(11)

EP 4 188 368 A1

(12)

(43) Date of publication: 07.06.2023 Bulletin 2023/23 (21) Application number: 21852519.4 (22) Date of filing: 30.04.2021

(51) International Patent Classification (IPC):  A61K 31/437(2006.01) A61K 31/4355(2006.01) A61K 31/496(2006.01) A61K 31/4985(2006.01) A61K 31/4025(2006.01) A61K 31/506(2006.01) A61P 35/02(2006.01) A61P 37/00(2006.01) A61K 31/424(2006.01) A61K 31/5377(2006.01) A61K 31/519(2006.01) A61K 31/4162(2006.01) A61K 31/52(2006.01) A61P 35/00(2006.01) A61P 31/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/4985; A61K 31/5377; A61P 37/00; A61P 35/00; A61P 35/02; A61K 31/519; A61P 31/00; A61K 45/06; A61K 31/635; A61K 9/2018   C-Sets: A61K 31/5377, A61K 2300/00; A61K 31/635, A61K 2300/00; A61K 31/519, A61K 2300/00; A61K 31/4985, A61K 2300/00; (86) International application number: PCT/US2021/030192 (87) International publication number: WO 2022/031330 (10.02.2022 Gazette 2022/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.08.2020 US 202063060413 P 18.11.2020 US 202063115312 P (71) Applicant: Curis, Inc. Lexington, MA 02421 (US)	(72) Inventors: VON ROEMELING, Reinhard Ridgefield, CT 06877 (US) MARTINEZ, Elizabeth Durham, NC 27713 (US) MARTELL, Robert Weston, MA 02493 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)