(19)

(11)

EP 4 188 546 A2

(12)

(88) Date of publication A3: 31.03.2022 (43) Date of publication: 07.06.2023 Bulletin 2023/23 (21) Application number: 21848742.9 (22) Date of filing: 28.07.2021

(51) International Patent Classification (IPC):  A61P 31/12(2006.01) A61K 9/48(2006.01) A61K 45/06(2006.01) (52) Cooperative Patent Classification (CPC): Y02A 50/30; A61P 31/14; A61K 45/06; A61K 38/33; A61K 31/485   C-Sets: A61K 38/33, A61K 2300/00; A61K 31/485, A61K 2300/00; (86) International application number: PCT/US2021/043569 (87) International publication number: WO 2022/026622 (03.02.2022 Gazette 2022/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.07.2020 US 202063057641 P (71) Applicant: Cytocom Inc. Orlando, Florida 32801 (US)	(72) Inventors: GRIFFIN, Noreen Orlando, FL 32801 (US) SHAN, Fengping Shenyang, Liaoning 110016 (CN) HANDLEY, Michael K Timnath, CO 80547 (US) (74) Representative: Murgitroyd & Company  Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)