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(11)

EP 4 189 096 A1

(12)

(43) Date of publication: 07.06.2023 Bulletin 2023/23 (21) Application number: 21850710.1 (22) Date of filing: 21.07.2021

(51) International Patent Classification (IPC):  C12N 15/86(2006.01) C12N 9/22(2006.01) C12N 15/88(2006.01) A61K 31/7088(2006.01) C12N 15/113(2010.01) C12N 15/10(2006.01) A61K 48/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2795/10143; C12N 2795/10142; C12N 15/102; C12N 2795/10121; C12N 7/00; C12N 2310/20 (86) International application number: PCT/IB2021/056248 (87) International publication number: WO 2022/023850 (03.02.2022 Gazette 2022/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.07.2020 US 202063058012 P 28.06.2021 US 202117359711 (71) Applicant: THE CATHOLIC UNIVERSITY OF AMERICA Washington, DC 20064 (US)	(72) Inventors: RAO, Venigalla B. Washington, DC 20064 (US) ZHU, Jingen Washington, DC 20064 (US) (74) Representative: FRKelly  27 Clyde Road Dublin D04 F838 Dublin D04 F838 (IE)