(19)

(11)

EP 4 189 317 A1

(12)

(43) Date of publication: 07.06.2023 Bulletin 2023/23 (21) Application number: 21848608.2 (22) Date of filing: 13.07.2021

(51) International Patent Classification (IPC):  F28F 3/08(2006.01) F28F 3/02(2006.01) F28D 9/00(2006.01) (52) Cooperative Patent Classification (CPC): F28D 9/0093; F28D 9/005; F28F 2270/00; F28F 2225/02 (86) International application number: PCT/US2021/041417 (87) International publication number: WO 2022/026172 (03.02.2022 Gazette 2022/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.07.2020 US 202063057020 P (71) Applicant: Repligen Corporation Waltham, MA 02453 (US)	(72) Inventor: PERREAULT, Mark Hudson, MA 01749 (US) (74) Representative: Arnold & Siedsma  Bezuidenhoutseweg 57 2594 AC The Hague 2594 AC The Hague (NL)