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EP 4 192 495 A1

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(43) Date of publication: 14.06.2023 Bulletin 2023/24 (21) Application number: 21773170.2 (22) Date of filing: 06.08.2021

(51) International Patent Classification (IPC):  A61K 38/18(2006.01) A61K 31/53(2006.01) A61P 1/16(2006.01) A61K 31/4178(2006.01) A61K 47/60(2017.01) (52) Cooperative Patent Classification (CPC): A61K 38/1825; A61K 47/60; A61K 31/53; A61P 1/16; A61K 31/517   C-Sets: A61K 31/53, A61K 2300/00; A61K 31/517, A61K 2300/00; (86) International application number: PCT/US2021/045090 (87) International publication number: WO 2022/032187 (10.02.2022 Gazette 2022/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.08.2020 US 202063063189 P 13.08.2020 US 202063065414 P 14.08.2020 US 202063065749 P 14.08.2020 US 202063065935 P 18.08.2020 US 202063067184 P (71) Applicants: Bristol-Myers Squibb Company Princeton, NJ 08543 (US) Universitaetsmedizin Berlin 10117 Berlin (DE) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen 52056 Aachen (DE) Universiteit Gent 9052 Gent (BE) Tacke, Frank 10117 Berlin (DE) Puengel, Tobias 10117 Berlin (DE) Lefere, Sander 9052 Gent-Zwijnaarde (BE)

(72) Inventors: BOEHM, Stephanie Lauren Philadelphia, Pennsylvania 19047 (US) ZHAO, Qihong Princeton, New Jersey 08540 (US) CHARLES, Edgar Davidson, III Westfield, New Jersey 07090 (US) ZINKER, Bradley A. Newtown, Pennsylvania 18940 (US) TACKE, Frank 10117 Berlin (DE) PUENGEL, Tobias 10117 Berlin (DE) LEFERE, Sander 9052 Gent-Zwijnaarde (BE) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)