<110>    Kanaph Therapeutics INC.

<120>    FUSION PROTEIN COMPRISING IL-12 AND ANTI-CD20 ANTIBODY AND USE THEREOF

<130>    SPO21-052-KNP-PCT

<150>    KR 10-2020-0100229
<151>    2020-08-11

<160>    285

<170>    KoPatentIn 3.0

<210>    1
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc knob


<400>    1
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys
    450    


<210>    2
<211>    213
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LC


<400>    2
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110 

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125 

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175 

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190 

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205 

Asn Arg Gly Glu Cys
    210            


<210>    3
<211>    755
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12-hu IgG1 Fc hole


<400>    3
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Lys
        755


<210>    4
<211>    755
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut1-hu IgG1 Fc hole


<400>    4
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Lys Arg Glu Ala Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Lys
        755


<210>    5
<211>    755
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2-hu IgG1 Fc hole


<400>    5
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Lys
        755


<210>    6
<211>    587
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (anti-hu CD20 VH)2-hu IgG1 Fc knob


<400>    6
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly
    130                 135                 140 

Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala
145                 150                 155                 160 

Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr
                165                 170                 175 

Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly
            180                 185                 190 

Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala
        195                 200                 205 

Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser
    210                 215                 220 

Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly
225                 230                 235                 240 

Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser
                245                 250                 255 

Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
            260                 265                 270 

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
        275                 280                 285 

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
    290                 295                 300 

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
305                 310                 315                 320 

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
                325                 330                 335 

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
            340                 345                 350 

Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
        355                 360                 365 

Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
    370                 375                 380 

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
385                 390                 395                 400 

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
                405                 410                 415 

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
            420                 425                 430 

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
        435                 440                 445 

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
    450                 455                 460 

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
465                 470                 475                 480 

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
                485                 490                 495 

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe
            500                 505                 510 

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        515                 520                 525 

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    530                 535                 540 

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
545                 550                 555                 560 

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                565                 570                 575 

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585        


<210>    7
<211>    334
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (anti-hu CD20 VL)2


<400>    7
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly
            100                 105                 110 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser
        115                 120                 125 

Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys
    130                 135                 140 

Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro
145                 150                 155                 160 

Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser
                165                 170                 175 

Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser
            180                 185                 190 

Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
        195                 200                 205 

Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
    210                 215                 220 

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
225                 230                 235                 240 

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
                245                 250                 255 

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
            260                 265                 270 

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
        275                 280                 285 

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
    290                 295                 300 

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
305                 310                 315                 320 

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
                325                 330                


<210>    8
<211>    713
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc knob-anti-hu CD20 scFv


<400>    8
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    450                 455                 460 

Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro
465                 470                 475                 480 

Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                485                 490                 495 

Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu
            500                 505                 510 

Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln
        515                 520                 525 

Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr
    530                 535                 540 

Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr
545                 550                 555                 560 

Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val
                565                 570                 575 

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser
            580                 585                 590 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
        595                 600                 605 

Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu
    610                 615                 620 

Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His
625                 630                 635                 640 

Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala
                645                 650                 655 

Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly
            660                 665                 670 

Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp
        675                 680                 685 

Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe
    690                 695                 700 

Gly Gly Gly Thr Lys Leu Glu Ile Lys
705                 710            


<210>    9
<211>    475
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LC-anti-hu CD20 scFv


<400>    9
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110 

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125 

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175 

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190 

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205 

Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    210                 215                 220 

Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val
225                 230                 235                 240 

Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr
                245                 250                 255 

Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly
            260                 265                 270 

Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr
        275                 280                 285 

Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser
    290                 295                 300 

Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
305                 310                 315                 320 

Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe
                325                 330                 335 

Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly
            340                 345                 350 

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        355                 360                 365 

Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro
    370                 375                 380 

Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr
385                 390                 395                 400 

Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile
                405                 410                 415 

Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly
            420                 425                 430 

Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala
        435                 440                 445 

Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro
    450                 455                 460 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
465                 470                 475


<210>    10
<211>    984
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc hole-hu scIL-12


<400>    10
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    450                 455                 460 

Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp
465                 470                 475                 480 

Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr
                485                 490                 495 

Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val
            500                 505                 510 

Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp
        515                 520                 525 

Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser
    530                 535                 540 

Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile
545                 550                 555                 560 

Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu
                565                 570                 575 

Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile
            580                 585                 590 

Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp
        595                 600                 605 

Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val
    610                 615                 620 

Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp
625                 630                 635                 640 

Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val
                645                 650                 655 

Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe
            660                 665                 670 

Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys
        675                 680                 685 

Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp
    690                 695                 700 

Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln
705                 710                 715                 720 

Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp
                725                 730                 735 

Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val
            740                 745                 750 

Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser
        755                 760                 765 

Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
    770                 775                 780 

Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe
785                 790                 795                 800 

Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met
                805                 810                 815 

Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu
            820                 825                 830 

Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu
        835                 840                 845 

Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser
    850                 855                 860 

Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys
865                 870                 875                 880 

Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu
                885                 890                 895 

Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met
            900                 905                 910 

Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile
        915                 920                 925 

Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln
    930                 935                 940 

Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu
945                 950                 955                 960 

Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg
                965                 970                 975 

Val Met Ser Tyr Leu Asn Ala Ser
            980                


<210>    11
<211>    984
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc hole-hu scIL-12 mut2


<400>    11
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    450                 455                 460 

Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp
465                 470                 475                 480 

Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr
                485                 490                 495 

Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val
            500                 505                 510 

Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp
        515                 520                 525 

Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser
    530                 535                 540 

Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile
545                 550                 555                 560 

Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu
                565                 570                 575 

Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile
            580                 585                 590 

Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp
        595                 600                 605 

Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val
    610                 615                 620 

Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp
625                 630                 635                 640 

Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val
                645                 650                 655 

Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe
            660                 665                 670 

Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys
        675                 680                 685 

Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp
    690                 695                 700 

Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln
705                 710                 715                 720 

Val Gln Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp
                725                 730                 735 

Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val
            740                 745                 750 

Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser
        755                 760                 765 

Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
    770                 775                 780 

Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe
785                 790                 795                 800 

Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met
                805                 810                 815 

Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu
            820                 825                 830 

Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu
        835                 840                 845 

Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser
    850                 855                 860 

Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys
865                 870                 875                 880 

Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu
                885                 890                 895 

Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met
            900                 905                 910 

Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile
        915                 920                 925 

Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln
    930                 935                 940 

Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu
945                 950                 955                 960 

Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg
                965                 970                 975 

Val Met Ser Tyr Leu Asn Ala Ser
            980                


<210>    12
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc knob DANG


<400>    12
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys
    450    


<210>    13
<211>    755
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12-hu IgG1 Fc hole DANG


<400>    13
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Lys
        755


<210>    14
<211>    755
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut1-hu IgG1 Fc hole DANG


<400>    14
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Lys Arg Glu Ala Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Lys
        755


<210>    15
<211>    755
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2-hu IgG1 Fc


<400>    15
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Lys
        755


<210>    16
<211>    454
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu FAP HC IgG1 Fc knob


<400>    16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr
             20                  25                  30 

Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
         35                  40                  45 

Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp
            100                 105                 110 

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125 

Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140 

Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 

Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175 

Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190 

Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205 

Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350 

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365 

Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445 

Ser Leu Ser Pro Gly Lys
    450                


<210>    17
<211>    220
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu FAP LC


<400>    17
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
  1               5                  10                  15 

Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
             20                  25                  30 

Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110 

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125 

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140 

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175 

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190 

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205 

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 220


<210>    18
<211>    454
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu FAP HC hu IgG1 Fc knob DANG


<400>    18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr
             20                  25                  30 

Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
         35                  40                  45 

Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp
            100                 105                 110 

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
        115                 120                 125 

Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
    130                 135                 140 

Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
145                 150                 155                 160 

Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                165                 170                 175 

Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
            180                 185                 190 

Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
        195                 200                 205 

Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
    210                 215                 220 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
225                 230                 235                 240 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala
            260                 265                 270 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly
    290                 295                 300 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350 

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        355                 360                 365 

Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445 

Ser Leu Ser Pro Gly Lys
    450                


<210>    19
<211>    227
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc knob DANG


<400>    19
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
  1               5                  10                  15 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
             20                  25                  30 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His
         35                  40                  45 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
     50                  55                  60 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr
 65                  70                  75                  80 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                 85                  90                  95 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            100                 105                 110 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        115                 120                 125 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    130                 135                 140 

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
145                 150                 155                 160 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                165                 170                 175 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            180                 185                 190 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        195                 200                 205 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    210                 215                 220 

Pro Gly Lys
225        


<210>    20
<211>    227
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc hole DANG


<400>    20
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
  1               5                  10                  15 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
             20                  25                  30 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His
         35                  40                  45 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
     50                  55                  60 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr
 65                  70                  75                  80 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                 85                  90                  95 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            100                 105                 110 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        115                 120                 125 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    130                 135                 140 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
145                 150                 155                 160 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                165                 170                 175 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
            180                 185                 190 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        195                 200                 205 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    210                 215                 220 

Pro Gly Lys
225        


<210>    21
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 (Rituximab) HC


<400>    21
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys
    450    


<210>    22
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc knob


<400>    22
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Trp Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Lys
    450    


<210>    23
<211>    213
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LC


<400>    23
Gln Ile Val Met Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Lys Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Asp Ala Ala Pro
            100                 105                 110 

Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly
        115                 120                 125 

Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn
    130                 135                 140 

Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn
145                 150                 155                 160 

Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser
                165                 170                 175 

Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr
            180                 185                 190 

Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe
        195                 200                 205 

Asn Arg Asn Glu Cys
    210            


<210>    24
<211>    764
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12-mu IgG2a Fc hole


<400>    24
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys
                245                 250                 255 

Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        755                 760                


<210>    25
<211>    764
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut1-mu IgG2a Fc hole


<400>    25
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Ala Lys
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        755                 760                


<210>    26
<211>    764
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2-mu IgG2a Fc hole


<400>    26
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala Ala Ala
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        755                 760                


<210>    27
<211>    587
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (anti-mu CD20 VH)2-mu IgG2a Fc knob


<400>    27
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly
    130                 135                 140 

Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala
145                 150                 155                 160 

Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys Gln Arg
                165                 170                 175 

Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Asn
            180                 185                 190 

Tyr Thr Lys Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val
        195                 200                 205 

Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser
    210                 215                 220 

Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Gly Tyr Tyr Gly Ser
225                 230                 235                 240 

Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                245                 250                 255 

Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys
            260                 265                 270 

Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly
        275                 280                 285 

Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser
    290                 295                 300 

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr
305                 310                 315                 320 

Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser
                325                 330                 335 

Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys
            340                 345                 350 

Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys
        355                 360                 365 

Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro
    370                 375                 380 

Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr
385                 390                 395                 400 

Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser
                405                 410                 415 

Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His
            420                 425                 430 

Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile
        435                 440                 445 

Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn
    450                 455                 460 

Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys
465                 470                 475                 480 

Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu
                485                 490                 495 

Glu Met Thr Lys Lys Gln Val Thr Leu Trp Cys Met Val Thr Asp Phe
            500                 505                 510 

Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu
        515                 520                 525 

Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr
    530                 535                 540 

Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg
545                 550                 555                 560 

Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His
                565                 570                 575 

Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
            580                 585        


<210>    28
<211>    334
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (anti-mu CD20 VL)2


<400>    28
Gln Ile Val Met Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Lys Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly
            100                 105                 110 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Met Ser Gln Ser
        115                 120                 125 

Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys
    130                 135                 140 

Arg Ala Arg Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro
145                 150                 155                 160 

Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser
                165                 170                 175 

Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser
            180                 185                 190 

Leu Thr Ile Thr Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
        195                 200                 205 

Gln Gln Trp Ser Ser Lys Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
    210                 215                 220 

Glu Ile Lys Arg Thr Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
225                 230                 235                 240 

Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu
                245                 250                 255 

Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly
            260                 265                 270 

Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser
        275                 280                 285 

Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp
    290                 295                 300 

Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr
305                 310                 315                 320 

Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
                325                 330                


<210>    29
<211>    713
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc knob-anti-mu CD20 scFv


<400>    29
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Trp Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    450                 455                 460 

Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro
465                 470                 475                 480 

Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                485                 490                 495 

Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu
            500                 505                 510 

Trp Ile Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln
        515                 520                 525 

Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr
    530                 535                 540 

Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr
545                 550                 555                 560 

Phe Cys Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr
                565                 570                 575 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
            580                 585                 590 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
        595                 600                 605 

Ile Val Met Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu
    610                 615                 620 

Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr Ile His
625                 630                 635                 640 

Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala
                645                 650                 655 

Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly
            660                 665                 670 

Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala Glu Asp
        675                 680                 685 

Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Lys Pro Pro Thr Phe
    690                 695                 700 

Gly Gly Gly Thr Lys Leu Glu Ile Lys
705                 710            


<210>    30
<211>    475
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LC-anti-mu CD20 scFv


<400>    30
Gln Ile Val Met Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Lys Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Asp Ala Ala Pro
            100                 105                 110 

Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly
        115                 120                 125 

Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn
    130                 135                 140 

Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn
145                 150                 155                 160 

Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser
                165                 170                 175 

Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr
            180                 185                 190 

Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe
        195                 200                 205 

Asn Arg Asn Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    210                 215                 220 

Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val
225                 230                 235                 240 

Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr
                245                 250                 255 

Phe Thr Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly
            260                 265                 270 

Leu Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr
        275                 280                 285 

Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser
    290                 295                 300 

Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
305                 310                 315                 320 

Val Tyr Phe Cys Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe
                325                 330                 335 

Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
            340                 345                 350 

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        355                 360                 365 

Ser Gln Ile Val Met Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro
    370                 375                 380 

Gly Glu Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr
385                 390                 395                 400 

Ile His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile
                405                 410                 415 

Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly
            420                 425                 430 

Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala
        435                 440                 445 

Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Lys Pro Pro
    450                 455                 460 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
465                 470                 475


<210>    31
<211>    987
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc hole-mu scIL-12


<400>    31
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Ser Cys Ala Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Val Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    450                 455                 460 

Gly Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp
465                 470                 475                 480 

Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr
                485                 490                 495 

Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val
            500                 505                 510 

Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp
        515                 520                 525 

Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser
    530                 535                 540 

His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile
545                 550                 555                 560 

Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn
                565                 570                 575 

Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp
            580                 585                 590 

Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala
        595                 600                 605 

Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp
    610                 615                 620 

Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr
625                 630                 635                 640 

Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala
                645                 650                 655 

Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg
            660                 665                 670 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu
        675                 680                 685 

Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser
    690                 695                 700 

Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg
705                 710                 715                 720 

Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly
                725                 730                 735 

Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly
            740                 745                 750 

Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser
        755                 760                 765 

Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser
    770                 775                 780 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser
785                 790                 795                 800 

Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr
                805                 810                 815 

Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys
            820                 825                 830 

Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser
        835                 840                 845 

Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys
    850                 855                 860 

Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro
865                 870                 875                 880 

Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr
                885                 890                 895 

Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala
            900                 905                 910 

Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu
        915                 920                 925 

Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr
    930                 935                 940 

Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys
945                 950                 955                 960 

Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr
                965                 970                 975 

Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala
            980                 985        


<210>    32
<211>    987
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc hole-mu scIL-12 mut2


<400>    32
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Ser Cys Ala Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Val Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    450                 455                 460 

Gly Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp
465                 470                 475                 480 

Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr
                485                 490                 495 

Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val
            500                 505                 510 

Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp
        515                 520                 525 

Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser
    530                 535                 540 

His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile
545                 550                 555                 560 

Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn
                565                 570                 575 

Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp
            580                 585                 590 

Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala
        595                 600                 605 

Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp
    610                 615                 620 

Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr
625                 630                 635                 640 

Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala
                645                 650                 655 

Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg
            660                 665                 670 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu
        675                 680                 685 

Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser
    690                 695                 700 

Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala
705                 710                 715                 720 

Ala Ala Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly
                725                 730                 735 

Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly
            740                 745                 750 

Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser
        755                 760                 765 

Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser
    770                 775                 780 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser
785                 790                 795                 800 

Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr
                805                 810                 815 

Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys
            820                 825                 830 

Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser
        835                 840                 845 

Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys
    850                 855                 860 

Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro
865                 870                 875                 880 

Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr
                885                 890                 895 

Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala
            900                 905                 910 

Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu
        915                 920                 925 

Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr
    930                 935                 940 

Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys
945                 950                 955                 960 

Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr
                965                 970                 975 

Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala
            980                 985        


<210>    33
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc knob DANG


<400>    33
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Gly Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Trp Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Lys
    450    


<210>    34
<211>    764
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12-mu IgG2a Fc hole DANG


<400>    34
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys
                245                 250                 255 

Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Gly Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        755                 760                


<210>    35
<211>    764
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut1-mu IgG2a Fc hole DANG


<400>    35
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Ala Lys
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Gly Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        755                 760                


<210>    36
<211>    764
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2-mu IgG2a Fc


<400>    36
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala Ala Ala
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        755                 760                


<210>    37
<211>    447
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu FAP HC mu IgG2a Fc knob


<400>    37
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
  1               5                  10                  15 

Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn
             20                  25                  30 

Gly Ile Asn Trp Leu Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Glu Ile Tyr Pro Arg Ser Thr Asn Thr Leu Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Asn Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Thr Leu Thr Ala Pro Phe Ala Phe Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu
        115                 120                 125 

Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys
    130                 135                 140 

Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser
145                 150                 155                 160 

Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
                165                 170                 175 

Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp
            180                 185                 190 

Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr
        195                 200                 205 

Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys
    210                 215                 220 

Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val
225                 230                 235                 240 

Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser
                245                 250                 255 

Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp
            260                 265                 270 

Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln
        275                 280                 285 

Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser
    290                 295                 300 

Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys
305                 310                 315                 320 

Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile
                325                 330                 335 

Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro
            340                 345                 350 

Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Trp Cys Met
        355                 360                 365 

Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn
    370                 375                 380 

Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser
385                 390                 395                 400 

Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn
                405                 410                 415 

Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu
            420                 425                 430 

His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        435                 440                 445 




<210>    38
<211>    213
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu FAP LC


<400>    38
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Gly Val Asn Phe Met
             20                  25                  30 

His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Phe
         35                  40                  45 

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro
            100                 105                 110 

Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly
        115                 120                 125 

Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn
    130                 135                 140 

Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn
145                 150                 155                 160 

Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser
                165                 170                 175 

Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr
            180                 185                 190 

Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe
        195                 200                 205 

Asn Arg Asn Glu Cys
    210            


<210>    39
<211>    447
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu FAP HC mu IgG2a Fc knob DANG


<400>    39
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
  1               5                  10                  15 

Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn
             20                  25                  30 

Gly Ile Asn Trp Leu Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Glu Ile Tyr Pro Arg Ser Thr Asn Thr Leu Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Asn Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Thr Leu Thr Ala Pro Phe Ala Phe Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu
        115                 120                 125 

Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys
    130                 135                 140 

Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser
145                 150                 155                 160 

Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
                165                 170                 175 

Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp
            180                 185                 190 

Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr
        195                 200                 205 

Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys
    210                 215                 220 

Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val
225                 230                 235                 240 

Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser
                245                 250                 255 

Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp
            260                 265                 270 

Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln
        275                 280                 285 

Thr Gln Thr His Arg Glu Asp Tyr Gly Ser Thr Leu Arg Val Val Ser
    290                 295                 300 

Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys
305                 310                 315                 320 

Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile
                325                 330                 335 

Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro
            340                 345                 350 

Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Trp Cys Met
        355                 360                 365 

Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn
    370                 375                 380 

Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser
385                 390                 395                 400 

Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn
                405                 410                 415 

Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu
            420                 425                 430 

His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        435                 440                 445 




<210>    40
<211>    233
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc knob DANG


<400>    40
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
  1               5                  10                  15 

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
             20                  25                  30 

Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
         35                  40                  45 

Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
     50                  55                  60 

Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
 65                  70                  75                  80 

Asp Tyr Gly Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
                 85                  90                  95 

Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
            100                 105                 110 

Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser
        115                 120                 125 

Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met
    130                 135                 140 

Thr Lys Lys Gln Val Thr Leu Trp Cys Met Val Thr Asp Phe Met Pro
145                 150                 155                 160 

Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn
                165                 170                 175 

Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met
            180                 185                 190 

Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser
        195                 200                 205 

Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr
    210                 215                 220 

Lys Ser Phe Ser Arg Thr Pro Gly Lys
225                 230            


<210>    41
<211>    233
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc hole DANG


<400>    41
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
  1               5                  10                  15 

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
             20                  25                  30 

Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
         35                  40                  45 

Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
     50                  55                  60 

Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
 65                  70                  75                  80 

Asp Tyr Gly Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
                 85                  90                  95 

Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
            100                 105                 110 

Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser
        115                 120                 125 

Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met
    130                 135                 140 

Thr Lys Lys Gln Val Thr Leu Trp Cys Met Val Thr Asp Phe Met Pro
145                 150                 155                 160 

Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn
                165                 170                 175 

Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met
            180                 185                 190 

Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser
        195                 200                 205 

Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr
    210                 215                 220 

Lys Ser Phe Ser Arg Thr Pro Gly Lys
225                 230            


<210>    42
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 (18B12) HC


<400>    42
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Lys
    450    


<210>    43
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc knob


<400>    43
caggtgcagc tgcagcagcc aggagcagag ctggtgaagc ctggagcctc tgtgaagatg         60

agctgcaagg cctccggcta caccttcaca agctataaca tgcactgggt gaagcagacc        120

ccaggaaggg gactggagtg gatcggagcc atctaccctg gcaacggcga cacatcctat        180

aatcagaagt ttaagggcaa ggccaccctg acagccgata agagctcctc taccgcctac        240

atgcagctga gctccctgac aagcgaggac tccgccgtgt actattgcgc cagaagcacc        300

tactatggcg gcgattggta cttcaacgtg tggggagcag gaaccacagt gaccgtgtct        360

gccgccagca caaagggacc atccgtgttt ccactggcac catctagcaa gtctaccagc        420

ggaggaacag ccgccctggg atgtctggtg aaggactact tcccagagcc cgtgaccgtg        480

tcctggaact ctggcgccct gacctccgga gtgcacacat ttcccgccgt gctgcagtcc        540

tctggcctgt actctctgag ctccgtggtg accgtgcctt ctagctccct gggcacccag        600

acatatatct gcaacgtgaa tcacaagcct tccaatacaa aggtggacaa gaaggtggag        660

ccaaagtctt gtgataagac ccacacatgc cccccttgtc ctgcaccaga gctgctggga        720

ggaccaagcg tgttcctgtt tccacccaag cccaaggaca ccctgatgat cagcaggacc        780

cctgaggtga catgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac        840

tggtacgtgg atggcgtgga ggtgcacaat gccaagacaa agccacggga ggagcagtac        900

aactctacct atagagtggt gagcgtgctg acagtgctgc accaggattg gctgaacggc        960

aaggagtata agtgcaaggt gtctaataag gccctgcccg cccctatcga gaagaccatc       1020

agcaaggcca agggccagcc tagggagcca caggtgtaca ccctgcctcc atctcgcgac       1080

gagctgacaa agaaccaggt gagcctgtgg tgtctggtga agggcttcta tccaagcgat       1140

atcgccgtgg agtgggagtc caatggccag cccgagaaca attacaagac cacaccccct       1200

gtgctggaca gcgatggctc cttctttctg tattccaagc tgaccgtgga taagtctaga       1260

tggcagcagg gcaacgtgtt ttcctgttct gtgatgcacg aggccctgca caatcactac       1320

acacagaaga gcctgtccct gtctcctggc aag                                    1353


<210>    44
<211>    639
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LC


<400>    44
cagatcgtgc tgagccagtc cccagcaatc ctgtctgcca gccctggaga gaaggtgacc         60

atgacatgcc gggccagctc ctctgtgagc tacatccact ggttccagca gaagccaggc        120

agctccccta agccatggat ctatgccaca agcaacctgg catccggagt gcccgtgcgg        180

ttttccggct ctggcagcgg cacctcctac tctctgacaa tcagcagagt ggaggcagag        240

gacgcagcaa cctactattg ccagcagtgg acctccaatc cccctacatt cggcggcggc        300

accaagctgg agatcaagag gacagtggcc gccccttccg tgttcatctt tccaccctct        360

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccca        420

cgcgaggcca aggtgcagtg gaaggtggat aacgccctgc agagcggcaa ttcccaggag        480

tctgtgacag agcaggacag caaggattcc acctattctc tgtctagcac cctgacactg        540

agcaaggccg attacgagaa gcacaaggtg tatgcctgcg aggtgacaca ccagggcctg        600

tcctctcccg tgaccaagtc cttcaacagg ggcgagtgt                               639


<210>    45
<211>    2265
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu scIL-12-hu IgG1 Fc hole


<400>    45
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca         60

ggcgagatgg tggtgctgac ctgcgacaca cccgaggagg atggcatcac ctggacactg        120

gatcagagct ccgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc        180

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg        240

ctgctgcaca agaaggagga cggcatctgg agcacagaca tcctgaagga tcagaaggag        300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt attccggccg gttcacctgt        360

tggtggctga ccacaatctc caccgatctg acattttctg tgaagtctag caggggctcc        420

tctgaccccc agggagtgac atgcggagca gccaccctga gcgccgagcg ggtgagaggc        480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca        540

gaggagtccc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat        600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag        660

ctgaagccac tgaagaatag ccgccaggtg gaggtgtcct gggagtaccc agacacctgg        720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagtccaag        780

agggagaaga aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag        840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg        900

gcctccgtgc cttgttctgg aggaggaggc agcggcggag gaggctccgg aggaggaggc        960

tctagaaatc tgccagtggc aacccctgac ccaggaatgt tcccttgcct gcaccactct       1020

cagaacctgc tgcgggccgt gagcaatatg ctgcagaagg ccagacagac actggagttt       1080

tacccctgta ccagcgagga gatcgaccac gaggatatca caaaggataa gacctccaca       1140

gtggaggcct gcctgcctct ggagctgacc aagaacgaga gctgtctgaa cagccgggag       1200

acatctttca tcaccaacgg cagctgcctg gcctccagaa agacatcttt tatgatggcc       1260

ctgtgcctgt ctagcatcta cgaggacctg aagatgtatc aggtggagtt caagaccatg       1320

aacgccaagc tgctgatgga cccaaagcgg cagatctttc tggatcagaa tatgctggcc       1380

gtgatcgacg agctgatgca ggccctgaac ttcaatagcg agacagtgcc ccagaagtcc       1440

tctctggagg agcctgactt ctacaagacc aagatcaagc tgtgcatcct gctgcacgcc       1500

ttccggatca gagccgtgac catcgataga gtgatgagct atctgaacgc aagcggcggc       1560

ggaggctctg gaggaggcgg cagcgacaag acccacacat gcccaccatg tccagcacct       1620

gagctgctgg gaggaccatc cgtgttcctg tttcctccaa agcccaagga tacactgatg       1680

atcagccgca cacctgaggt gacctgcgtg gtggtggacg tgtcccacga ggaccccgag       1740

gtgaagttta actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg       1800

gaggagcagt acaactctac atatcgcgtg gtgagcgtgc tgaccgtgct gcaccaggac       1860

tggctgaacg gcaaggagta caagtgcaag gtgtctaata aggccctgcc agcccccatc       1920

gagaagacca tcagcaaggc aaagggacag ccaagggagc ctcaggtgta tacactgccc       1980

cctagccgcg atgagctgac caagaaccag gtgtccctgt cttgtgccgt gaagggcttc       2040

tacccatccg acatcgccgt ggagtgggag tctaatggcc agcccgagaa caattataag       2100

accacaccac ccgtgctgga ctccgatggc tctttctttc tggtgagcaa gctgacagtg       2160

gacaagtcca gatggcagca gggcaacgtg tttagctgct ccgtgatgca cgaggccctg       2220

cacaatcact acacccagaa gtctctgagc ctgtcccctg gcaag                       2265


<210>    46
<211>    2265
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut1-hu IgG1 Fc hole


<400>    46
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca         60

ggcgagatgg tggtgctgac ctgcgacaca cccgaggagg atggcatcac ctggacactg        120

gatcagagct ccgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc        180

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg        240

ctgctgcaca agaaggagga cggcatctgg agcacagaca tcctgaagga tcagaaggag        300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt attccggccg gttcacctgt        360

tggtggctga ccacaatctc caccgatctg acattttctg tgaagtctag caggggctcc        420

tctgaccccc agggagtgac atgcggagca gccaccctga gcgccgagcg ggtgagaggc        480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca        540

gaggagtccc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat        600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag        660

ctgaagccac tgaagaatag ccgccaggtg gaggtgtcct gggagtaccc agacacctgg        720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg agcatccaag        780

agggaggcaa aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag        840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg        900

gcctccgtgc cttgttctgg aggaggaggc agcggcggag gaggctccgg aggaggaggc        960

tctagaaatc tgccagtggc aacccctgac ccaggaatgt tcccttgcct gcaccactct       1020

cagaacctgc tgcgggccgt gagcaatatg ctgcagaagg ccagacagac actggagttt       1080

tacccctgta ccagcgagga gatcgaccac gaggatatca caaaggataa gacctccaca       1140

gtggaggcct gcctgcctct ggagctgacc aagaacgaga gctgtctgaa cagccgggag       1200

acatctttca tcaccaacgg cagctgcctg gcctccagaa agacatcttt tatgatggcc       1260

ctgtgcctgt ctagcatcta cgaggacctg aagatgtatc aggtggagtt caagaccatg       1320

aacgccaagc tgctgatgga cccaaagcgg cagatctttc tggatcagaa tatgctggcc       1380

gtgatcgacg agctgatgca ggccctgaac ttcaatagcg agacagtgcc ccagaagtcc       1440

tctctggagg agcctgactt ctacaagacc aagatcaagc tgtgcatcct gctgcacgcc       1500

ttccggatca gagccgtgac catcgataga gtgatgagct atctgaacgc aagcggcggc       1560

ggaggctctg gaggaggcgg cagcgacaag acccacacat gcccaccatg tccagcacct       1620

gagctgctgg gaggaccatc cgtgttcctg tttcctccaa agcccaagga tacactgatg       1680

atcagccgca cacctgaggt gacctgcgtg gtggtggacg tgtcccacga ggaccccgag       1740

gtgaagttta actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg       1800

gaggagcagt acaactctac atatcgcgtg gtgagcgtgc tgaccgtgct gcaccaggac       1860

tggctgaacg gcaaggagta caagtgcaag gtgtctaata aggccctgcc agcccccatc       1920

gagaagacca tcagcaaggc aaagggacag ccaagggagc ctcaggtgta tacactgccc       1980

cctagccgcg atgagctgac caagaaccag gtgtccctgt cttgtgccgt gaagggcttc       2040

tacccatccg acatcgccgt ggagtgggag tctaatggcc agcccgagaa caattataag       2100

accacaccac ccgtgctgga ctccgatggc tctttctttc tggtgagcaa gctgacagtg       2160

gacaagtcca gatggcagca gggcaacgtg tttagctgct ccgtgatgca cgaggccctg       2220

cacaatcact acacccagaa gtctctgagc ctgtcccctg gcaag                       2265


<210>    47
<211>    2268
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2-hu IgG1 Fc hole


<400>    47
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca         60

ggcgagatgg tggtgctgac ctgcgacaca cccgaggagg atggcatcac ctggacactg        120

gatcagagct ccgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc        180

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg        240

ctgctgcaca agaaggagga cggcatctgg agcacagaca tcctgaagga tcagaaggag        300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt attccggccg gttcacctgt        360

tggtggctga ccacaatctc caccgatctg acattttctg tgaagtctag caggggctcc        420

tctgaccccc agggagtgac atgcggagca gccaccctga gcgccgagcg ggtgagaggc        480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca        540

gaggagtccc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat        600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag        660

ctgaagccac tgaagaatag ccgccaggtg gaggtgtcct gggagtaccc agacacctgg        720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg cgcctccgct        780

agggaggccg ctgaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag        840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg        900

gcctccgtgc cttgttctgg aggaggaggc agcggcggag gaggctccgg aggaggaggc        960

tctagaaatc tgccagtggc aacccctgac ccaggaatgt tcccttgcct gcaccactct       1020

cagaacctgc tgcgggccgt gagcaatatg ctgcagaagg ccagacagac actggagttt       1080

tacccctgta ccagcgagga gatcgaccac gaggatatca caaaggataa gacctccaca       1140

gtggaggcct gcctgcctct ggagctgacc aagaacgaga gctgtctgaa cagccgggag       1200

acatctttca tcaccaacgg cagctgcctg gcctccagaa agacatcttt tatgatggcc       1260

ctgtgcctgt ctagcatcta cgaggacctg aagatgtatc aggtggagtt caagaccatg       1320

aacgccaagc tgctgatgga cccaaagcgg cagatctttc tggatcagaa tatgctggcc       1380

gtgatcgacg agctgatgca ggccctgaac ttcaatagcg agacagtgcc ccagaagtcc       1440

tctctggagg agcctgactt ctacaagacc aagatcaagc tgtgcatcct gctgcacgcc       1500

ttccggatca gagccgtgac catcgataga gtgatgagct atctgaacgc aagcggcggc       1560

ggaggctctg gaggaggcgg cagcgacaag acccacacat gcccaccatg tccagcacct       1620

gagctgctgg gaggaccatc cgtgttcctg tttcctccaa agcccaagga tacactgatg       1680

atcagccgca cacctgaggt gacctgcgtg gtggtggacg tgtcccacga ggaccccgag       1740

gtgaagttta actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg       1800

gaggagcagt acaactctac atatcgcgtg gtgagcgtgc tgaccgtgct gcaccaggac       1860

tggctgaacg gcaaggagta caagtgcaag gtgtctaata aggccctgcc agcccccatc       1920

gagaagacca tcagcaaggc aaagggacag ccaagggagc ctcaggtgta tacactgccc       1980

cctagccgcg atgagctgac caagaaccag gtgtccctgt cttgtgccgt gaagggcttc       2040

tacccatccg acatcgccgt ggagtgggag tctaatggcc agcccgagaa caattataag       2100

accacaccac ccgtgctgga ctccgatggc tctttctttc tggtgagcaa gctgacagtg       2160

gacaagtcca gatggcagca gggcaacgtg tttagctgct ccgtgatgca cgaggccctg       2220

cacaatcact acacccagaa gtctctgagc ctgtcccctg gcaagtga                    2268


<210>    48
<211>    1761
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (anti-hu CD20 VH)2-hu IgG1 Fc knob


<400>    48
caagtgcagc tgcagcagcc tggcgccgag ctggtgaaac caggagcttc tgtgaagatg         60

agctgtaaag ccagcggcta caccttcacc tcttataata tgcactgggt caagcagacc        120

cctggaagag gcctggaatg gatcggcgct atctaccccg gcaacggcga caccagctac        180

aaccagaagt tcaagggcaa ggccacactg accgccgaca agtccagctc tacagcctac        240

atgcagctga gcagcctgac aagcgaggac agcgccgtgt actactgcgc ccggagcacc        300

tactacggcg gagattggta ctttaacgtg tggggcgccg gcaccacagt gaccgtgtcc        360

gccggtggag gtggctcagg aggaggcggt tctggcggag gaggtagtca ggtgcagctg        420

cagcagccag gagcagagct ggtgaagcct ggagcctctg tgaagatgag ctgcaaggcc        480

tccggctaca ccttcacaag ctataacatg cactgggtga agcagacccc aggaagggga        540

ctggagtgga tcggagccat ctaccctggc aacggcgaca catcctataa tcagaagttt        600

aagggcaagg ccaccctgac agccgataag agctcctcta ccgcctacat gcagctgagc        660

tccctgacaa gcgaggactc cgccgtgtac tattgcgcca gaagcaccta ctatggcggc        720

gattggtact tcaacgtgtg gggagcagga accacagtga ccgtgtctgc cgccagcaca        780

aagggaccat ccgtgtttcc actggcacca tctagcaagt ctaccagcgg aggaacagcc        840

gccctgggat gtctggtgaa ggactacttc ccagagcccg tgaccgtgtc ctggaactct        900

ggcgccctga cctccggagt gcacacattt cccgccgtgc tgcagtcctc tggcctgtac        960

tctctgagct ccgtggtgac cgtgccttct agctccctgg gcacccagac atatatctgc       1020

aacgtgaatc acaagccttc caatacaaag gtggacaaga aggtggagcc aaagtcttgt       1080

gataagaccc acacatgccc cccttgtcct gcaccagagc tgctgggagg accaagcgtg       1140

ttcctgtttc cacccaagcc caaggacacc ctgatgatca gcaggacccc tgaggtgaca       1200

tgcgtggtgg tggacgtgtc ccacgaggac ccagaggtga agttcaactg gtacgtggat       1260

ggcgtggagg tgcacaatgc caagacaaag ccacgggagg agcagtacaa ctctacctat       1320

agagtggtga gcgtgctgac agtgctgcac caggattggc tgaacggcaa ggagtataag       1380

tgcaaggtgt ctaataaggc cctgcccgcc cctatcgaga agaccatcag caaggccaag       1440

ggccagccta gggagccaca ggtgtacacc ctgcctccat ctcgcgacga gctgacaaag       1500

aaccaggtga gcctgtggtg tctggtgaag ggcttctatc caagcgatat cgccgtggag       1560

tgggagtcca atggccagcc cgagaacaat tacaagacca caccccctgt gctggacagc       1620

gatggctcct tctttctgta ttccaagctg accgtggata agtctagatg gcagcagggc       1680

aacgtgtttt cctgttctgt gatgcacgag gccctgcaca atcactacac acagaagagc       1740

ctgtccctgt ctcctggcaa g                                                 1761


<210>    49
<211>    1002
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (anti-hu CD20 VL)2


<400>    49
caaatcgtgc tgagccagag ccctgctatc ctgtccgcct ctccaggcga gaaggtgacc         60

atgacctgta gagccagcag cagcgtgtcc tacatccact ggtttcagca gaaacctggc        120

tctagcccta agccttggat ctacgccaca agcaacctgg cctccggcgt ccctgtgcgg        180

ttcagcggca gcggcagcgg cacctcttat agcctgacca tcagcagagt ggaagccgag        240

gacgccgcta catactactg ccagcagtgg acatctaacc cccccacctt cggcggagga        300

accaagctgg aaattaaggg tggaggtggc tcaggaggag gcggttctgg cggaggaggt        360

agtcagatcg tgctgagcca gtccccagca atcctgtctg ccagccctgg agagaaggtg        420

accatgacat gccgggccag ctcctctgtg agctacatcc actggttcca gcagaagcca        480

ggcagctccc ctaagccatg gatctatgcc acaagcaacc tggcatccgg agtgcccgtg        540

cggttttccg gctctggcag cggcacctcc tactctctga caatcagcag agtggaggca        600

gaggacgcag caacctacta ttgccagcag tggacctcca atccccctac attcggcggc        660

ggcaccaagc tggagatcaa gaggacagtg gccgcccctt ccgtgttcat ctttccaccc        720

tctgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac        780

ccacgcgagg ccaaggtgca gtggaaggtg gataacgccc tgcagagcgg caattcccag        840

gagtctgtga cagagcagga cagcaaggat tccacctatt ctctgtctag caccctgaca        900

ctgagcaagg ccgattacga gaagcacaag gtgtatgcct gcgaggtgac acaccagggc        960

ctgtcctctc ccgtgaccaa gtccttcaac aggggcgagt gt                          1002


<210>    50
<211>    2139
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc knob-anti-hu CD20 scFv


<400>    50
caggtgcagc tgcagcagcc aggagcagag ctggtgaagc ctggagcctc tgtgaagatg         60

agctgcaagg cctccggcta caccttcaca agctataaca tgcactgggt gaagcagacc        120

ccaggaaggg gactggagtg gatcggagcc atctaccctg gcaacggcga cacatcctat        180

aatcagaagt ttaagggcaa ggccaccctg acagccgata agagctcctc taccgcctac        240

atgcagctga gctccctgac aagcgaggac tccgccgtgt actattgcgc cagaagcacc        300

tactatggcg gcgattggta cttcaacgtg tggggagcag gaaccacagt gaccgtgtct        360

gccgccagca caaagggacc atccgtgttt ccactggcac catctagcaa gtctaccagc        420

ggaggaacag ccgccctggg atgtctggtg aaggactact tcccagagcc cgtgaccgtg        480

tcctggaact ctggcgccct gacctccgga gtgcacacat ttcccgccgt gctgcagtcc        540

tctggcctgt actctctgag ctccgtggtg accgtgcctt ctagctccct gggcacccag        600

acatatatct gcaacgtgaa tcacaagcct tccaatacaa aggtggacaa gaaggtggag        660

ccaaagtctt gtgataagac ccacacatgc cccccttgtc ctgcaccaga gctgctggga        720

ggaccaagcg tgttcctgtt tccacccaag cccaaggaca ccctgatgat cagcaggacc        780

cctgaggtga catgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac        840

tggtacgtgg atggcgtgga ggtgcacaat gccaagacaa agccacggga ggagcagtac        900

aactctacct atagagtggt gagcgtgctg acagtgctgc accaggattg gctgaacggc        960

aaggagtata agtgcaaggt gtctaataag gccctgcccg cccctatcga gaagaccatc       1020

agcaaggcca agggccagcc tagggagcca caggtgtaca ccctgcctcc atctcgcgac       1080

gagctgacaa agaaccaggt gagcctgtgg tgtctggtga agggcttcta tccaagcgat       1140

atcgccgtgg agtgggagtc caatggccag cccgagaaca attacaagac cacaccccct       1200

gtgctggaca gcgatggctc cttctttctg tattccaagc tgaccgtgga taagtctaga       1260

tggcagcagg gcaacgtgtt ttcctgttct gtgatgcacg aggccctgca caatcactac       1320

acacagaaga gcctgtccct gtctcctggc aagggtggag gtggctcagg aggaggcggt       1380

tctggcggag gaggtagtca agtgcagctg cagcagcctg gcgccgagct ggtgaaacca       1440

ggagcttctg tgaagatgag ctgtaaagcc agcggctaca ccttcacctc ttataatatg       1500

cactgggtca agcagacccc tggaagaggc ctggaatgga tcggcgctat ctaccccggc       1560

aacggcgaca ccagctacaa ccagaagttc aagggcaagg ccacactgac cgccgacaag       1620

tccagctcta cagcctacat gcagctgagc agcctgacaa gcgaggacag cgccgtgtac       1680

tactgcgccc ggagcaccta ctacggcgga gattggtact ttaacgtgtg gggcgccggc       1740

accacagtga ccgtgtccgc cggcggagga ggtagcggtg gtggaggatc tggcggtggc       1800

ggaagcggtg gaggcggttc acaaatcgtg ctgagccaga gccctgctat cctgtccgcc       1860

tctccaggcg agaaggtgac catgacctgt agagccagca gcagcgtgtc ctacatccac       1920

tggtttcagc agaaacctgg ctctagccct aagccttgga tctacgccac aagcaacctg       1980

gcctccggcg tccctgtgcg gttcagcggc agcggcagcg gcacctctta tagcctgacc       2040

atcagcagag tggaagccga ggacgccgct acatactact gccagcagtg gacatctaac       2100

ccccccacct tcggcggagg aaccaagctg gaaattaag                              2139


<210>    51
<211>    1425
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LC-anti-hu CD20 scFv


<400>    51
cagatcgtgc tgagccagtc cccagcaatc ctgtctgcca gccctggaga gaaggtgacc         60

atgacatgcc gggccagctc ctctgtgagc tacatccact ggttccagca gaagccaggc        120

agctccccta agccatggat ctatgccaca agcaacctgg catccggagt gcccgtgcgg        180

ttttccggct ctggcagcgg cacctcctac tctctgacaa tcagcagagt ggaggcagag        240

gacgcagcaa cctactattg ccagcagtgg acctccaatc cccctacatt cggcggcggc        300

accaagctgg agatcaagag gacagtggcc gccccttccg tgttcatctt tccaccctct        360

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccca        420

cgcgaggcca aggtgcagtg gaaggtggat aacgccctgc agagcggcaa ttcccaggag        480

tctgtgacag agcaggacag caaggattcc acctattctc tgtctagcac cctgacactg        540

agcaaggccg attacgagaa gcacaaggtg tatgcctgcg aggtgacaca ccagggcctg        600

tcctctcccg tgaccaagtc cttcaacagg ggcgagtgtg gtggaggtgg ctcaggagga        660

ggcggttctg gcggaggagg tagtcaagtg cagctgcagc agcctggcgc cgagctggtg        720

aaaccaggag cttctgtgaa gatgagctgt aaagccagcg gctacacctt cacctcttat        780

aatatgcact gggtcaagca gacccctgga agaggcctgg aatggatcgg cgctatctac        840

cccggcaacg gcgacaccag ctacaaccag aagttcaagg gcaaggccac actgaccgcc        900

gacaagtcca gctctacagc ctacatgcag ctgagcagcc tgacaagcga ggacagcgcc        960

gtgtactact gcgcccggag cacctactac ggcggagatt ggtactttaa cgtgtggggc       1020

gccggcacca cagtgaccgt gtccgccggc ggaggaggta gcggtggtgg aggatctggc       1080

ggtggcggaa gcggtggagg cggttcacaa atcgtgctga gccagagccc tgctatcctg       1140

tccgcctctc caggcgagaa ggtgaccatg acctgtagag ccagcagcag cgtgtcctac       1200

atccactggt ttcagcagaa acctggctct agccctaagc cttggatcta cgccacaagc       1260

aacctggcct ccggcgtccc tgtgcggttc agcggcagcg gcagcggcac ctcttatagc       1320

ctgaccatca gcagagtgga agccgaggac gccgctacat actactgcca gcagtggaca       1380

tctaaccccc ccaccttcgg cggaggaacc aagctggaaa ttaag                       1425


<210>    52
<211>    2952
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc hole-hu scIL-12


<400>    52
caggtgcagc tgcagcagcc aggagcagag ctggtgaagc ctggagcctc tgtgaagatg         60

agctgcaagg cctccggcta caccttcaca agctataaca tgcactgggt gaagcagacc        120

ccaggaaggg gactggagtg gatcggagcc atctaccctg gcaacggcga cacatcctat        180

aatcagaagt ttaagggcaa ggccaccctg acagccgata agagctcctc taccgcctac        240

atgcagctga gctccctgac aagcgaggac tccgccgtgt actattgcgc cagaagcacc        300

tactatggcg gcgattggta cttcaacgtg tggggagcag gaaccacagt gaccgtgtct        360

gccgccagca caaagggacc atccgtgttt ccactggcac catctagcaa gtctaccagc        420

ggaggaacag ccgccctggg atgtctggtg aaggactact tcccagagcc cgtgaccgtg        480

tcctggaact ctggcgccct gacctccgga gtgcacacat ttcccgccgt gctgcagtcc        540

tctggcctgt actctctgag ctccgtggtg accgtgcctt ctagctccct gggcacccag        600

acatatatct gcaacgtgaa tcacaagcct tccaatacaa aggtggacaa gaaggtggag        660

ccaaagtctt gtgacaagac ccacacatgc ccaccatgtc cagcacctga gctgctggga        720

ggaccatccg tgttcctgtt tcctccaaag cccaaggata cactgatgat cagccgcaca        780

cctgaggtga cctgcgtggt ggtggacgtg tcccacgagg accccgaggt gaagtttaac        840

tggtacgtgg acggcgtgga ggtgcacaat gccaagacca agcccaggga ggagcagtac        900

aactctacat atcgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc        960

aaggagtaca agtgcaaggt gtctaataag gccctgccag cccccatcga gaagaccatc       1020

agcaaggcaa agggacagcc aagggagcct caggtgtata cactgccccc tagccgcgat       1080

gagctgacca agaaccaggt gtccctgtct tgtgccgtga agggcttcta cccatccgac       1140

atcgccgtgg agtgggagtc taatggccag cccgagaaca attataagac cacaccaccc       1200

gtgctggact ccgatggctc tttctttctg gtgagcaagc tgacagtgga caagtccaga       1260

tggcagcagg gcaacgtgtt tagctgctcc gtgatgcacg aggccctgca caatcactac       1320

acccagaagt ctctgagcct gtcccctggc aagggtggag gtggctcagg aggaggcggt       1380

tctggcggag gaggtagtat ctgggagctg aagaaggacg tgtacgtggt ggagctggac       1440

tggtatcctg atgccccagg cgagatggtg gtgctgacct gcgacacacc cgaggaggat       1500

ggcatcacct ggacactgga tcagagctcc gaggtgctgg gcagcggcaa gaccctgaca       1560

atccaggtga aggagttcgg cgacgccggc cagtacacct gtcacaaggg aggagaggtg       1620

ctgagccact ccctgctgct gctgcacaag aaggaggacg gcatctggag cacagacatc       1680

ctgaaggatc agaaggagcc aaagaacaag accttcctgc ggtgcgaggc caagaattat       1740

tccggccggt tcacctgttg gtggctgacc acaatctcca ccgatctgac attttctgtg       1800

aagtctagca ggggctcctc tgacccccag ggagtgacat gcggagcagc caccctgagc       1860

gccgagcggg tgagaggcga taacaaggag tacgagtatt ccgtggagtg ccaggaggac       1920

tctgcctgtc ctgcagcaga ggagtccctg ccaatcgaag tgatggtgga tgccgtgcac       1980

aagctgaagt acgagaatta tacaagctcc ttctttatca gggacatcat caagcctgat       2040

ccccctaaga acctgcagct gaagccactg aagaatagcc gccaggtgga ggtgtcctgg       2100

gagtacccag acacctggtc cacaccccac tcttatttca gcctgacctt ttgcgtgcag       2160

gtgcagggca agtccaagag ggagaagaag gaccgcgtgt tcaccgataa gacatctgcc       2220

accgtgatct gtcggaagaa cgcctctatc agcgtgcggg cccaggatag atactattct       2280

agctcctgga gcgagtgggc ctccgtgcct tgttctggag gaggaggcag cggcggagga       2340

ggctccggag gaggaggctc tagaaatctg ccagtggcaa cccctgaccc aggaatgttc       2400

ccttgcctgc accactctca gaacctgctg cgggccgtga gcaatatgct gcagaaggcc       2460

agacagacac tggagtttta cccctgtacc agcgaggaga tcgaccacga ggatatcaca       2520

aaggataaga cctccacagt ggaggcctgc ctgcctctgg agctgaccaa gaacgagagc       2580

tgtctgaaca gccgggagac atctttcatc accaacggca gctgcctggc ctccagaaag       2640

acatctttta tgatggccct gtgcctgtct agcatctacg aggacctgaa gatgtatcag       2700

gtggagttca agaccatgaa cgccaagctg ctgatggacc caaagcggca gatctttctg       2760

gatcagaata tgctggccgt gatcgacgag ctgatgcagg ccctgaactt caatagcgag       2820

acagtgcccc agaagtcctc tctggaggag cctgacttct acaagaccaa gatcaagctg       2880

tgcatcctgc tgcacgcctt ccggatcaga gccgtgacca tcgatagagt gatgagctat       2940

ctgaacgcaa gc                                                           2952


<210>    53
<211>    2952
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc hole-hu scIL-12 mut2


<400>    53
caggtgcagc tgcagcagcc aggagcagag ctggtgaagc ctggagcctc tgtgaagatg         60

agctgcaagg cctccggcta caccttcaca agctataaca tgcactgggt gaagcagacc        120

ccaggaaggg gactggagtg gatcggagcc atctaccctg gcaacggcga cacatcctat        180

aatcagaagt ttaagggcaa ggccaccctg acagccgata agagctcctc taccgcctac        240

atgcagctga gctccctgac aagcgaggac tccgccgtgt actattgcgc cagaagcacc        300

tactatggcg gcgattggta cttcaacgtg tggggagcag gaaccacagt gaccgtgtct        360

gccgccagca caaagggacc atccgtgttt ccactggcac catctagcaa gtctaccagc        420

ggaggaacag ccgccctggg atgtctggtg aaggactact tcccagagcc cgtgaccgtg        480

tcctggaact ctggcgccct gacctccgga gtgcacacat ttcccgccgt gctgcagtcc        540

tctggcctgt actctctgag ctccgtggtg accgtgcctt ctagctccct gggcacccag        600

acatatatct gcaacgtgaa tcacaagcct tccaatacaa aggtggacaa gaaggtggag        660

ccaaagtctt gtgacaagac ccacacatgc ccaccatgtc cagcacctga gctgctggga        720

ggaccatccg tgttcctgtt tcctccaaag cccaaggata cactgatgat cagccgcaca        780

cctgaggtga cctgcgtggt ggtggacgtg tcccacgagg accccgaggt gaagtttaac        840

tggtacgtgg acggcgtgga ggtgcacaat gccaagacca agcccaggga ggagcagtac        900

aactctacat atcgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc        960

aaggagtaca agtgcaaggt gtctaataag gccctgccag cccccatcga gaagaccatc       1020

agcaaggcaa agggacagcc aagggagcct caggtgtata cactgccccc tagccgcgat       1080

gagctgacca agaaccaggt gtccctgtct tgtgccgtga agggcttcta cccatccgac       1140

atcgccgtgg agtgggagtc taatggccag cccgagaaca attataagac cacaccaccc       1200

gtgctggact ccgatggctc tttctttctg gtgagcaagc tgacagtgga caagtccaga       1260

tggcagcagg gcaacgtgtt tagctgctcc gtgatgcacg aggccctgca caatcactac       1320

acccagaagt ctctgagcct gtcccctggc aagggtggag gtggctcagg aggaggcggt       1380

tctggcggag gaggtagtat ctgggagctg aagaaggacg tgtacgtggt ggagctggac       1440

tggtatcctg atgccccagg cgagatggtg gtgctgacct gcgacacacc cgaggaggat       1500

ggcatcacct ggacactgga tcagagctcc gaggtgctgg gcagcggcaa gaccctgaca       1560

atccaggtga aggagttcgg cgacgccggc cagtacacct gtcacaaggg aggagaggtg       1620

ctgagccact ccctgctgct gctgcacaag aaggaggacg gcatctggag cacagacatc       1680

ctgaaggatc agaaggagcc aaagaacaag accttcctgc ggtgcgaggc caagaattat       1740

tccggccggt tcacctgttg gtggctgacc acaatctcca ccgatctgac attttctgtg       1800

aagtctagca ggggctcctc tgacccccag ggagtgacat gcggagcagc caccctgagc       1860

gccgagcggg tgagaggcga taacaaggag tacgagtatt ccgtggagtg ccaggaggac       1920

tctgcctgtc ctgcagcaga ggagtccctg ccaatcgaag tgatggtgga tgccgtgcac       1980

aagctgaagt acgagaatta tacaagctcc ttctttatca gggacatcat caagcctgat       2040

ccccctaaga acctgcagct gaagccactg aagaatagcc gccaggtgga ggtgtcctgg       2100

gagtacccag acacctggtc cacaccccac tcttatttca gcctgacctt ttgcgtgcag       2160

gtgcagggcg cctccgctag ggaggccgct gaccgcgtgt tcaccgataa gacatctgcc       2220

accgtgatct gtcggaagaa cgcctctatc agcgtgcggg cccaggatag atactattct       2280

agctcctgga gcgagtgggc ctccgtgcct tgttctggag gaggaggcag cggcggagga       2340

ggctccggag gaggaggctc tagaaatctg ccagtggcaa cccctgaccc aggaatgttc       2400

ccttgcctgc accactctca gaacctgctg cgggccgtga gcaatatgct gcagaaggcc       2460

agacagacac tggagtttta cccctgtacc agcgaggaga tcgaccacga ggatatcaca       2520

aaggataaga cctccacagt ggaggcctgc ctgcctctgg agctgaccaa gaacgagagc       2580

tgtctgaaca gccgggagac atctttcatc accaacggca gctgcctggc ctccagaaag       2640

acatctttta tgatggccct gtgcctgtct agcatctacg aggacctgaa gatgtatcag       2700

gtggagttca agaccatgaa cgccaagctg ctgatggacc caaagcggca gatctttctg       2760

gatcagaata tgctggccgt gatcgacgag ctgatgcagg ccctgaactt caatagcgag       2820

acagtgcccc agaagtcctc tctggaggag cctgacttct acaagaccaa gatcaagctg       2880

tgcatcctgc tgcacgcctt ccggatcaga gccgtgacca tcgatagagt gatgagctat       2940

ctgaacgcaa gc                                                           2952


<210>    54
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc knob DANG


<400>    54
caggtgcagc tgcagcagcc aggagcagag ctggtgaagc ctggagcctc tgtgaagatg         60

agctgcaagg cctccggcta caccttcaca agctataaca tgcactgggt gaagcagacc        120

ccaggaaggg gactggagtg gatcggagcc atctaccctg gcaacggcga cacatcctat        180

aatcagaagt ttaagggcaa ggccaccctg acagccgata agagctcctc taccgcctac        240

atgcagctga gctccctgac aagcgaggac tccgccgtgt actattgcgc cagaagcacc        300

tactatggcg gcgattggta cttcaacgtg tggggagcag gaaccacagt gaccgtgtct        360

gccgccagca caaagggacc atccgtgttt ccactggcac catctagcaa gtctaccagc        420

ggaggaacag ccgccctggg atgtctggtg aaggactact tcccagagcc cgtgaccgtg        480

tcctggaact ctggcgccct gacctccgga gtgcacacat ttcccgccgt gctgcagtcc        540

tctggcctgt actctctgag ctccgtggtg accgtgcctt ctagctccct gggcacccag        600

acatatatct gcaacgtgaa tcacaagcct tccaatacaa aggtggacaa gaaggtggag        660

ccaaagtctt gtgataagac ccacacatgc cccccttgtc ctgcaccaga gctgctggga        720

ggaccaagcg tgttcctgtt tccacccaag cccaaggaca ccctgatgat cagcaggacc        780

cctgaggtga catgcgtggt ggtggccgtg tcccacgagg acccagaggt gaagttcaac        840

tggtacgtgg atggcgtgga ggtgcacaat gccaagacaa agccacggga ggagcagtac        900

ggctctacct atagagtggt gagcgtgctg acagtgctgc accaggattg gctgaacggc        960

aaggagtata agtgcaaggt gtctaataag gccctgcccg cccctatcga gaagaccatc       1020

agcaaggcca agggccagcc tagggagcca caggtgtaca ccctgcctcc atctcgcgac       1080

gagctgacaa agaaccaggt gagcctgtgg tgtctggtga agggcttcta tccaagcgat       1140

atcgccgtgg agtgggagtc caatggccag cccgagaaca attacaagac cacaccccct       1200

gtgctggaca gcgatggctc cttctttctg tattccaagc tgaccgtgga taagtctaga       1260

tggcagcagg gcaacgtgtt ttcctgttct gtgatgcacg aggccctgca caatcactac       1320

acacagaaga gcctgtccct gtctcctggc aag                                    1353


<210>    55
<211>    2265
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu scIL-12-hu IgG1 Fc hole DANG


<400>    55
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca         60

ggcgagatgg tggtgctgac ctgcgacaca cccgaggagg atggcatcac ctggacactg        120

gatcagagct ccgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc        180

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg        240

ctgctgcaca agaaggagga cggcatctgg agcacagaca tcctgaagga tcagaaggag        300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt attccggccg gttcacctgt        360

tggtggctga ccacaatctc caccgatctg acattttctg tgaagtctag caggggctcc        420

tctgaccccc agggagtgac atgcggagca gccaccctga gcgccgagcg ggtgagaggc        480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca        540

gaggagtccc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat        600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag        660

ctgaagccac tgaagaatag ccgccaggtg gaggtgtcct gggagtaccc agacacctgg        720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagtccaag        780

agggagaaga aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag        840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg        900

gcctccgtgc cttgttctgg aggaggaggc agcggcggag gaggctccgg aggaggaggc        960

tctagaaatc tgccagtggc aacccctgac ccaggaatgt tcccttgcct gcaccactct       1020

cagaacctgc tgcgggccgt gagcaatatg ctgcagaagg ccagacagac actggagttt       1080

tacccctgta ccagcgagga gatcgaccac gaggatatca caaaggataa gacctccaca       1140

gtggaggcct gcctgcctct ggagctgacc aagaacgaga gctgtctgaa cagccgggag       1200

acatctttca tcaccaacgg cagctgcctg gcctccagaa agacatcttt tatgatggcc       1260

ctgtgcctgt ctagcatcta cgaggacctg aagatgtatc aggtggagtt caagaccatg       1320

aacgccaagc tgctgatgga cccaaagcgg cagatctttc tggatcagaa tatgctggcc       1380

gtgatcgacg agctgatgca ggccctgaac ttcaatagcg agacagtgcc ccagaagtcc       1440

tctctggagg agcctgactt ctacaagacc aagatcaagc tgtgcatcct gctgcacgcc       1500

ttccggatca gagccgtgac catcgataga gtgatgagct atctgaacgc aagcggcggc       1560

ggaggctctg gaggaggcgg cagcgacaag acccacacat gcccaccatg tccagcacct       1620

gagctgctgg gaggaccatc cgtgttcctg tttcctccaa agcccaagga tacactgatg       1680

atcagccgca cacctgaggt gacctgcgtg gtggtggccg tgtcccacga ggaccccgag       1740

gtgaagttta actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg       1800

gaggagcagt acggctctac atatcgcgtg gtgagcgtgc tgaccgtgct gcaccaggac       1860

tggctgaacg gcaaggagta caagtgcaag gtgtctaata aggccctgcc agcccccatc       1920

gagaagacca tcagcaaggc aaagggacag ccaagggagc ctcaggtgta tacactgccc       1980

cctagccgcg atgagctgac caagaaccag gtgtccctgt cttgtgccgt gaagggcttc       2040

tacccatccg acatcgccgt ggagtgggag tctaatggcc agcccgagaa caattataag       2100

accacaccac ccgtgctgga ctccgatggc tctttctttc tggtgagcaa gctgacagtg       2160

gacaagtcca gatggcagca gggcaacgtg tttagctgct ccgtgatgca cgaggccctg       2220

cacaatcact acacccagaa gtctctgagc ctgtcccctg gcaag                       2265


<210>    56
<211>    2265
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut1-hu IgG1 Fc hole DANG


<400>    56
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca         60

ggcgagatgg tggtgctgac ctgcgacaca cccgaggagg atggcatcac ctggacactg        120

gatcagagct ccgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc        180

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg        240

ctgctgcaca agaaggagga cggcatctgg agcacagaca tcctgaagga tcagaaggag        300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt attccggccg gttcacctgt        360

tggtggctga ccacaatctc caccgatctg acattttctg tgaagtctag caggggctcc        420

tctgaccccc agggagtgac atgcggagca gccaccctga gcgccgagcg ggtgagaggc        480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca        540

gaggagtccc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat        600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag        660

ctgaagccac tgaagaatag ccgccaggtg gaggtgtcct gggagtaccc agacacctgg        720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg agcatccaag        780

agggaggcaa aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag        840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg        900

gcctccgtgc cttgttctgg aggaggaggc agcggcggag gaggctccgg aggaggaggc        960

tctagaaatc tgccagtggc aacccctgac ccaggaatgt tcccttgcct gcaccactct       1020

cagaacctgc tgcgggccgt gagcaatatg ctgcagaagg ccagacagac actggagttt       1080

tacccctgta ccagcgagga gatcgaccac gaggatatca caaaggataa gacctccaca       1140

gtggaggcct gcctgcctct ggagctgacc aagaacgaga gctgtctgaa cagccgggag       1200

acatctttca tcaccaacgg cagctgcctg gcctccagaa agacatcttt tatgatggcc       1260

ctgtgcctgt ctagcatcta cgaggacctg aagatgtatc aggtggagtt caagaccatg       1320

aacgccaagc tgctgatgga cccaaagcgg cagatctttc tggatcagaa tatgctggcc       1380

gtgatcgacg agctgatgca ggccctgaac ttcaatagcg agacagtgcc ccagaagtcc       1440

tctctggagg agcctgactt ctacaagacc aagatcaagc tgtgcatcct gctgcacgcc       1500

ttccggatca gagccgtgac catcgataga gtgatgagct atctgaacgc aagcggcggc       1560

ggaggctctg gaggaggcgg cagcgacaag acccacacat gcccaccatg tccagcacct       1620

gagctgctgg gaggaccatc cgtgttcctg tttcctccaa agcccaagga tacactgatg       1680

atcagccgca cacctgaggt gacctgcgtg gtggtggccg tgtcccacga ggaccccgag       1740

gtgaagttta actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg       1800

gaggagcagt acggctctac atatcgcgtg gtgagcgtgc tgaccgtgct gcaccaggac       1860

tggctgaacg gcaaggagta caagtgcaag gtgtctaata aggccctgcc agcccccatc       1920

gagaagacca tcagcaaggc aaagggacag ccaagggagc ctcaggtgta tacactgccc       1980

cctagccgcg atgagctgac caagaaccag gtgtccctgt cttgtgccgt gaagggcttc       2040

tacccatccg acatcgccgt ggagtgggag tctaatggcc agcccgagaa caattataag       2100

accacaccac ccgtgctgga ctccgatggc tctttctttc tggtgagcaa gctgacagtg       2160

gacaagtcca gatggcagca gggcaacgtg tttagctgct ccgtgatgca cgaggccctg       2220

cacaatcact acacccagaa gtctctgagc ctgtcccctg gcaag                       2265


<210>    57
<211>    2265
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2-hu IgG1 Fc


<400>    57
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca         60

ggcgagatgg tggtgctgac ctgcgacaca cccgaggagg atggcatcac ctggacactg        120

gatcagagct ccgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc        180

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg        240

ctgctgcaca agaaggagga cggcatctgg agcacagaca tcctgaagga tcagaaggag        300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt attccggccg gttcacctgt        360

tggtggctga ccacaatctc caccgatctg acattttctg tgaagtctag caggggctcc        420

tctgaccccc agggagtgac atgcggagca gccaccctga gcgccgagcg ggtgagaggc        480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca        540

gaggagtccc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat        600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag        660

ctgaagccac tgaagaatag ccgccaggtg gaggtgtcct gggagtaccc agacacctgg        720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg cgcctccgct        780

agggaggccg ctgaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag        840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg        900

gcctccgtgc cttgttctgg aggaggaggc agcggcggag gaggctccgg aggaggaggc        960

tctagaaatc tgccagtggc aacccctgac ccaggaatgt tcccttgcct gcaccactct       1020

cagaacctgc tgcgggccgt gagcaatatg ctgcagaagg ccagacagac actggagttt       1080

tacccctgta ccagcgagga gatcgaccac gaggatatca caaaggataa gacctccaca       1140

gtggaggcct gcctgcctct ggagctgacc aagaacgaga gctgtctgaa cagccgggag       1200

acatctttca tcaccaacgg cagctgcctg gcctccagaa agacatcttt tatgatggcc       1260

ctgtgcctgt ctagcatcta cgaggacctg aagatgtatc aggtggagtt caagaccatg       1320

aacgccaagc tgctgatgga cccaaagcgg cagatctttc tggatcagaa tatgctggcc       1380

gtgatcgacg agctgatgca ggccctgaac ttcaatagcg agacagtgcc ccagaagtcc       1440

tctctggagg agcctgactt ctacaagacc aagatcaagc tgtgcatcct gctgcacgcc       1500

ttccggatca gagccgtgac catcgataga gtgatgagct atctgaacgc aagcggcggc       1560

ggaggctctg gaggaggcgg cagcgacaag acccacacat gcccaccatg tccagcacct       1620

gagctgctgg gaggaccatc cgtgttcctg tttcctccaa agcccaagga tacactgatg       1680

atcagccgca cacctgaggt gacctgcgtg gtggtggacg tgtcccacga ggaccccgag       1740

gtgaagttta actggtacgt ggacggcgtg gaggtgcaca atgccaagac caagcccagg       1800

gaggagcagt acaactctac atatcgcgtg gtgagcgtgc tgaccgtgct gcaccaggac       1860

tggctgaacg gcaaggagta caagtgcaag gtgtctaata aggccctgcc agcccccatc       1920

gagaagacca tcagcaaggc aaagggacag ccaagggagc ctcaggtgta tacactgccc       1980

cctagccgcg atgagctgac caagaaccag gtgtccctga cttgtctcgt gaagggcttc       2040

tacccatccg acatcgccgt ggagtgggag tctaatggcc agcccgagaa caattataag       2100

accacaccac ccgtgctgga ctccgatggc tctttctttc tgtacagcaa gctgacagtg       2160

gacaagtcca gatggcagca gggcaacgtg tttagctgct ccgtgatgca cgaggccctg       2220

cacaatcact acacccagaa gtctctgagc ctgtcccctg gcaag                       2265


<210>    58
<211>    1362
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu FAP HC hu IgG1 Fc knob


<400>    58
caggtgcagc tggtgcagtc cggagcagag gtgaagaagc caggagcctc tgtgaaggtg         60

agctgcaaga cctccagata caccttcaca gagtatacaa tccactgggt gcgccaggca        120

cctggacagc ggctggagtg gatcggaggc atcaacccca acaatggcat ccctaactac        180

aatcagaagt ttaagggcag agtgaccatc acagtggaca cctccgcctc tacagcctat        240

atggagctga gctccctgag gagcgaggat accgccgtgt actattgcgc ccggagaagg        300

atcgcctacg gctatgacga gggccacgcc atggattact ggggccaggg caccctggtg        360

acagtgtcta gcgcctctac caagggacca agcgtgttcc cactggcacc atcctctaag        420

agcacctccg gaggaacagc cgccctgggc tgtctggtga aggactattt cccagagccc        480

gtgacagtgt cctggaactc tggcgccctg acctccggag tgcacacatt tcctgccgtg        540

ctgcagagct ccggcctgta cagcctgtct agcgtggtga ccgtgccatc ctctagcctg        600

ggcacccaga catatatctg caacgtgaat cacaagccta gcaatacaaa ggtggacaag        660

aaggtggagc caaagtcctg tgataagacc cacacatgcc ccccttgtcc tgcaccagag        720

ctgctgggag gaccaagcgt gttcctgttt ccacccaagc ccaaggacac cctgatgatc        780

tctcgcaccc cagaggtgac atgcgtggtg gtggacgtga gccacgagga ccccgaggtg        840

aagtttaact ggtacgtgga tggcgtggag gtgcacaatg ccaagaccaa gccaagagag        900

gagcagtaca actccaccta tagggtggtg tctgtgctga cagtgctgca ccaggattgg        960

ctgaacggca aggagtataa gtgcaaggtg tccaataagg ccctgcccgc ccctatcgag       1020

aagaccatct ctaaggcaaa gggacagcct agggagccac aggtgtacac cctgcctcca       1080

tcccgggacg agctgacaaa gaaccaggtg tctctgtggt gtctggtgaa gggcttctat       1140

ccctctgata tcgccgtgga gtgggagagc aatggccagc ctgagaacaa ttacaagacc       1200

acaccccctg tgctggacag cgatggctcc ttctttctgt atagcaagct gaccgtggat       1260

aagtcccggt ggcagcaggg caacgtgttt tcttgtagcg tgatgcacga ggccctgcac       1320

aatcactaca cacagaagtc cctgtctctg agccctggca ag                          1362


<210>    59
<211>    660
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu FAP LC


<400>    59
gacatcgtga tgacccagtc ccctgattct ctggccgtga gcctgggaga gagggcaaca         60

atcaactgca agagctccca gagcctgctg tactcccgca accagaagaa ttacctggcc        120

tggtatcagc agaagcccgg ccagccccct aagctgctga tcttctgggc atctaccagg        180

gagagcggag tgcctgacag attttctggc agcggcttcg gcacagactt caccctgaca        240

atctctagcc tgcaggccga ggacgtggcc gtgtactatt gccagcagta cttctcctat        300

cctctgacct ttggccaggg cacaaaggtg gagatcaaga ggaccgtggc agcaccaagc        360

gtgttcatct ttccaccctc cgacgagcag ctgaagtccg gcaccgcctc tgtggtgtgc        420

ctgctgaaca atttctaccc aagggaggcc aaggtgcagt ggaaggtgga taacgccctg        480

cagagcggca attcccagga gtctgtgacc gagcaggaca gcaaggattc cacatattct        540

ctgtcctcta ccctgacact gtctaaggcc gattacgaga agcacaaggt gtatgcatgc        600

gaggtgaccc accagggact gagctcccca gtgacaaagt cctttaatcg gggcgagtgt        660

                                                                         660


<210>    60
<211>    1362
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu FAP HC hu IgG1 Fc knob DANG


<400>    60
caggtgcagc tggtgcagtc cggagcagag gtgaagaagc caggagcctc tgtgaaggtg         60

agctgcaaga cctccagata caccttcaca gagtatacaa tccactgggt gcgccaggca        120

cctggacagc ggctggagtg gatcggaggc atcaacccca acaatggcat ccctaactac        180

aatcagaagt ttaagggcag agtgaccatc acagtggaca cctccgcctc tacagcctat        240

atggagctga gctccctgag gagcgaggat accgccgtgt actattgcgc ccggagaagg        300

atcgcctacg gctatgacga gggccacgcc atggattact ggggccaggg caccctggtg        360

acagtgtcta gcgcctctac caagggacca agcgtgttcc cactggcacc atcctctaag        420

agcacctccg gaggaacagc cgccctgggc tgtctggtga aggactattt cccagagccc        480

gtgacagtgt cctggaactc tggcgccctg acctccggag tgcacacatt tcctgccgtg        540

ctgcagagct ccggcctgta cagcctgtct agcgtggtga ccgtgccatc ctctagcctg        600

ggcacccaga catatatctg caacgtgaat cacaagccta gcaatacaaa ggtggacaag        660

aaggtggagc caaagtcctg tgataagacc cacacatgcc ccccttgtcc tgcaccagag        720

ctgctgggag gaccaagcgt gttcctgttt ccacccaagc ccaaggacac cctgatgatc        780

tctcgcaccc cagaggtgac atgcgtggtg gtggccgtga gccacgagga ccccgaggtg        840

aagtttaact ggtacgtgga tggcgtggag gtgcacaatg ccaagaccaa gccaagagag        900

gagcagtacg gctccaccta tagggtggtg tctgtgctga cagtgctgca ccaggattgg        960

ctgaacggca aggagtataa gtgcaaggtg tccaataagg ccctgcccgc ccctatcgag       1020

aagaccatct ctaaggcaaa gggacagcct agggagccac aggtgtacac cctgcctcca       1080

tcccgggacg agctgacaaa gaaccaggtg tctctgtggt gtctggtgaa gggcttctat       1140

ccctctgata tcgccgtgga gtgggagagc aatggccagc ctgagaacaa ttacaagacc       1200

acaccccctg tgctggacag cgatggctcc ttctttctgt atagcaagct gaccgtggat       1260

aagtcccggt ggcagcaggg caacgtgttt tcttgtagcg tgatgcacga ggccctgcac       1320

aatcactaca cacagaagtc cctgtctctg agccctggca ag                          1362


<210>    61
<211>    681
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc knob DANG


<400>    61
gacaagaccc acacatgccc accttgtcca gcaccagagc tgctgggagg accatccgtg         60

ttcctgtttc cacccaagcc caaggatacc ctgatgatca gcaggacccc agaggtgaca        120

tgcgtggtgg tggccgtgtc ccacgaggac cctgaggtga agttcaactg gtacgtggat        180

ggcgtggagg tgcacaatgc caagacaaag ccacgggagg agcagtacgg ctccacctat        240

agagtggtgt ctgtgctgac agtgctgcac caggactggc tgaacggcaa ggagtataag        300

tgcaaggtgt ctaataaggc cctgcctgcc ccaatcgaga agaccatcag caaggcaaag        360

ggacagccaa gggagcctca ggtgtacacc ctgcctccat cccgcgacga gctgacaaag        420

aaccaggtgt ctctgtggtg tctggtgaag ggcttctatc cttctgatat cgccgtggag        480

tgggagagca atggccagcc agagaacaat tacaagacca caccccctgt gctggactct        540

gatggcagct tctttctgta tagcaagctg accgtggata agtccaggtg gcagcagggc        600

aacgtgttta gctgttccgt gatgcacgag gccctgcaca atcactacac acagaagtct        660

ctgagcctgt cccctggcaa g                                                  681


<210>    62
<211>    681
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc hole DANG


<400>    62
gacaagaccc acacatgccc accttgtcca gcaccagagc tgctgggagg accatccgtg         60

ttcctgtttc cacccaagcc caaggatacc ctgatgatca gcaggacccc agaggtgaca        120

tgcgtggtgg tggccgtgtc ccacgaggac cctgaggtga agttcaactg gtacgtggat        180

ggcgtggagg tgcacaatgc caagacaaag ccacgggagg agcagtacgg cagcacctat        240

agagtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa ggagtacaag        300

tgcaaggtgt ctaataaggc cctgcctgcc ccaatcgaga agaccatcag caaggcaaag        360

ggacagccaa gggagcctca ggtgtatacc ctgcctccaa gccgcgacga gctgacaaag        420

aaccaggtga gcctgtcctg tgccgtgaag ggcttctacc cttccgatat cgccgtggag        480

tgggagtcta atggccagcc agagaacaat tataagacca caccccctgt gctggactcc        540

gatggctctt tctttctggt gtctaagctg accgtggata agagcaggtg gcagcagggc        600

aacgtgtttt cttgtagcgt gatgcacgag gccctgcaca atcactatac acagaagtcc        660

ctgtctctga gccctggcaa g                                                  681


<210>    63
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 (Rituximab) HC


<400>    63
caggtgcagc tgcagcagcc aggagcagag ctggtgaagc ctggagcctc tgtgaagatg         60

agctgcaagg cctccggcta caccttcaca agctataaca tgcactgggt gaagcagacc        120

ccaggaaggg gactggagtg gatcggagcc atctaccctg gcaacggcga cacatcctat        180

aatcagaagt ttaagggcaa ggccaccctg acagccgata agagctcctc taccgcctac        240

atgcagctga gctccctgac aagcgaggac tccgccgtgt actattgcgc cagaagcacc        300

tactatggcg gcgattggta cttcaacgtg tggggagcag gaaccacagt gaccgtgtct        360

gccgccagca caaagggacc atccgtgttt ccactggcac catctagcaa gtctaccagc        420

ggaggaacag ccgccctggg atgtctggtg aaggactact tcccagagcc cgtgaccgtg        480

tcctggaact ctggcgccct gacctccgga gtgcacacat ttcccgccgt gctgcagtcc        540

tctggcctgt actctctgag ctccgtggtg accgtgcctt ctagctccct gggcacccag        600

acatatatct gcaacgtgaa tcacaagcct tccaatacaa aggtggacaa gaaggtggag        660

ccaaagtctt gtgataagac ccacacatgc cccccttgtc ctgcaccaga gctgctggga        720

ggaccaagcg tgttcctgtt tccacccaag cccaaggaca ccctgatgat cagcaggacc        780

cctgaggtga catgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac        840

tggtacgtgg atggcgtgga ggtgcacaat gccaagacaa agccacggga ggagcagtac        900

aactctacct atagagtggt gagcgtgctg acagtgctgc accaggattg gctgaacggc        960

aaggagtata agtgcaaggt gtctaataag gccctgcccg cccctatcga gaagaccatc       1020

agcaaggcca agggccagcc tagggagcca caggtgtaca ccctgcctcc atctcgcgac       1080

gagctgacaa agaaccaggt gagcctgacc tgtctggtga agggcttcta tccaagcgat       1140

atcgccgtgg agtgggagtc caatggccag cccgagaaca attacaagac cacaccccct       1200

gtgctggaca gcgatggctc cttctttctg tattccaagc tgaccgtgga taagtctaga       1260

tggcagcagg gcaacgtgtt ttcctgttct gtgatgcacg aggccctgca caatcactac       1320

acacagaaga gcctgtccct gtctcctggc aag                                    1353


<210>    64
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc knob


<400>    64
caggtgcagc tgcagcagcc aggagcagag ctggtgaggc caggcacctc tgtgaagctg         60

agctgcaagg cctccggcta caccttcaca tcttattgga tgcactggat caagcagagg        120

ccaggacagg gactggagtg gatcggcgtg atcgacccct ccgataacta caccaagtac        180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca ccagctcctc tacagcctac        240

atgcagctga gctccctgac atccgaggat tctgccgtgt atttctgtgc ccgggagggc        300

tactatggct ctagcccatg gtttgcctac tggggccagg gcaccctggt gacagtgtcc        360

tctgccaaga ccacagcccc cagcgtgtat cctctggccc cagtgtgcgg cgataccaca        420

ggcagctccg tgaccctggg ctgtctggtg aagggctact tccctgagcc agtgaccctg        480

acatggaact ctggcagcct gtctagcgga gtgcacacct ttccagccgt gctgcagtcc        540

gatctgtata cactgtcctc tagcgtgacc gtgacatcct ctacctggcc ctcccagtct        600

atcacatgca acgtggccca ccctgccagc tccaccaagg tggacaagaa gatcgagccc        660

cggggcccta caatcaagcc atgtccacct tgcaagtgtc cagcacctaa tctgctggga        720

ggacctagcg tgttcatctt tccacccaag atcaaggacg tgctgatgat cagcctgtcc        780

cctatcgtga cctgcgtggt ggtggacgtg agcgaggacg atccagatgt gcagatctcc        840

tggttcgtga acaatgtgga ggtgcacacc gcccagaccc agacacaccg ggaggactac        900

aactccacac tgagagtggt gtctgccctg cctatccagc accaggactg gatgtccggc        960

aaggagttta agtgcaaggt gaacaataag gatctgccag cccccatcga gcggaccatc       1020

tctaagccta agggcagcgt gagagcccca caggtgtatg tgctgcctcc acccgaggag       1080

gagatgacca agaagcaggt gacactgtgg tgtatggtga ccgacttcat gcctgaggat       1140

atctacgtgg agtggaccaa caatggcaag acagagctga actataagaa tacagagcca       1200

gtgctggaca gcgatggctc ctactttatg tatagcaagc tgagggtgga gaagaagaac       1260

tgggtggagc gcaattctta cagctgttcc gtggtgcacg agggcctgca caatcaccac       1320

accacaaagt ctttcagcag aacccccggc aag                                    1353


<210>    65
<211>    639
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LC


<400>    65
cagatcgtga tgagccagtc ccctgccatc ctgtccgcca gccctggcga gaaggtgaca         60

atgacctgca gggccagatc ctccgtgtcc tacatccact ggtaccagca gaagcccggc        120

agcagcccta agccctggat ctacgccacc agcaacctgg ccagcggcgt gcctggcaga        180

ttttccggct ccggcagcgg caccagctac agcctgacaa tcacaagggt ggaggccgag        240

gatgccgcca catactactg ccagcagtgg agctccaagc ctcccacctt cggcggcggc        300

accaagctgg agatcaagag gaccgacgcc gcccccaccg tgtccatctt tcccccttcc        360

tccgagcagc tgacctccgg cggcgcttcc gtggtgtgtt tcctgaataa tttctaccct        420

aaggatatca acgtgaagtg gaagatcgat ggcagcgaga ggcagaatgg cgtgctgaat        480

agctggaccg accaggacag caaggatagc acctacagca tgagctccac actgaccctg        540

acaaaggacg agtacgagag gcacaattcc tacacatgtg aggccacaca caagacctcc        600

acctccccta tcgtgaagtc cttcaacagg aacgagtgc                               639


<210>    66
<211>    2292
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu scIL-12-mu IgG2a Fc hole


<400>    66
atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg attggacacc tgacgccccc         60

ggcgagacag tgaacctgac atgcgatacc cctgaggagg atgatatcac atggacctcc        120

gatcagagac acggcgtgat cggcagcggc aagaccctga caatcaccgt gaaggagttt        180

ctggatgccg gccagtacac ctgtcacaag ggcggcgaga cactgagcca ctcccacctg        240

ctgctgcaca agaaggagaa tggcatctgg tccaccgaga tcctgaagaa cttcaagaac        300

aagaccttcc tgaagtgtga ggcccctaat tactccggca ggtttacatg ctcctggctg        360

gtgcagagaa acatggacct gaagtttaat atcaagagct cctcctccag ccccgatagc        420

agagccgtga cctgtggcat ggccagcctg agcgccgaga aggtgaccct ggatcagagg        480

gattacgaga agtactccgt gtcctgtcag gaggatgtga catgtcctac agccgaggag        540

acactgccta tcgagctggc cctggaggcc aggcagcaga ataagtacga gaactacagc        600

acaagctttt tcatcaggga catcatcaag cccgatcccc ccaagaacct gcagatgaag        660

cccctgaaga acagccaggt ggaggtgtcc tgggagtacc ctgatagctg gtccacccct        720

cactcctact tctccctgaa gttctttgtg agaatccaga gaaagaagga gaagatgaag        780

gagacagagg agggctgcaa tcagaagggc gccttcctgg tggagaagac atccaccgag        840

gtgcagtgta agggcggcaa cgtgtgcgtg caggcccagg acagatacta caattccagc        900

tgtagcaagt gggcctgtgt gccttgtaga gtgagatccg gcggcggcgg ctccggagga        960

ggaggaagcg gaggaggcgg ctccagagtg atccctgtgt ccggccctgc cagatgtctg       1020

tcccagagca gaaacctgct gaagaccaca gacgacatgg tgaagacagc cagagagaag       1080

ctgaagcact acagctgcac cgccgaggac atcgaccacg aggatatcac aagagaccag       1140

acatccaccc tgaagacatg tctgcctctg gagctgcaca agaatgagtc ctgcctggcc       1200

accagagaga cctccagcac caccaggggc agctgcctgc cccctcagaa gacctccctg       1260

atgatgacac tgtgcctggg cagcatctac gaggacctga agatgtacca gaccgagttc       1320

caggccatca atgccgccct gcagaaccac aaccaccagc agatcatcct ggataagggc       1380

atgctggtgg ccatcgacga gctgatgcag agcctgaacc acaatggcga gaccctgagg       1440

cagaagcctc ctgtgggcga ggccgatccc tacagagtga agatgaagct gtgtatcctg       1500

ctgcacgcct tttccacaag ggtggtgacc atcaacaggg tcatgggcta cctgtccagc       1560

gccggcggcg gcggcagcgg aggaggaggc tccgagccac gcggccccac aatcaagcca       1620

tgcccccctt gcaagtgtcc tgcaccaaat ctgctgggag gaccatccgt gttcatcttt       1680

ccacccaaga tcaaggacgt gctgatgatc agcctgtccc caatcgtgac ctgcgtggtc       1740

gtggacgtga gcgaggacga tcctgatgtg cagatctcct ggttcgtgaa caatgtggag       1800

gtgcacaccg cccagaccca gacacaccgg gaggactaca actccacact gagagtggtg       1860

tctgccctgc ccatccagca ccaggactgg atgagcggca aggagtttaa gtgcaaggtg       1920

aacaataagg atctgcccgc ccctatcgag cggacaatct ctaagcctaa gggcagcgtg       1980

agagccccac aggtgtatgt gctgcctcca cccgaggagg agatgaccaa gaagcaggtg       2040

acactgtctt gtgccgtgac cgacttcatg cctgaggata tctatgtgga gtggaccaac       2100

aatggcaaga cagagctgaa ctacaagaat acagagccag tgctggactc cgatggctct       2160

tacttcatgg tgagcaagct gagggtggag aagaagaact gggtggagcg caattcttac       2220

agctgctccg tggtgcacga gggcctgcac aaccaccaca ccacaaagtc ttttagccgg       2280

acccctggca ag                                                           2292


<210>    67
<211>    2292
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut1-mu IgG2a Fc hole


<400>    67
atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg attggacacc tgacgccccc         60

ggcgagacag tgaacctgac atgcgatacc cctgaggagg atgatatcac atggacctcc        120

gatcagagac acggcgtgat cggcagcggc aagaccctga caatcaccgt gaaggagttt        180

ctggatgccg gccagtacac ctgtcacaag ggcggcgaga cactgagcca ctcccacctg        240

ctgctgcaca agaaggagaa tggcatctgg tccaccgaga tcctgaagaa cttcaagaac        300

aagaccttcc tgaagtgtga ggcccctaat tactccggca ggtttacatg ctcctggctg        360

gtgcagagaa acatggacct gaagtttaat atcaagagct cctcctccag ccccgatagc        420

agagccgtga cctgtggcat ggccagcctg agcgccgaga aggtgaccct ggatcagagg        480

gattacgaga agtactccgt gtcctgtcag gaggatgtga catgtcctac agccgaggag        540

acactgccta tcgagctggc cctggaggcc aggcagcaga ataagtacga gaactacagc        600

acaagctttt tcatcaggga catcatcaag cccgatcccc ccaagaacct gcagatgaag        660

cccctgaaga acagccaggt ggaggtgtcc tgggagtacc ctgatagctg gtccacccct        720

cactcctact tctccctgaa gttctttgtg agaatccaga gagccaagga gaagatggcc        780

gagacagagg agggctgcaa tcagaagggc gccttcctgg tggagaagac atccaccgag        840

gtgcagtgta agggcggcaa cgtgtgcgtg caggcccagg acagatacta caattccagc        900

tgtagcaagt gggcctgtgt gccttgtaga gtgagatccg gcggcggcgg ctccggagga        960

ggaggaagcg gaggaggcgg ctccagagtg atccctgtgt ccggccctgc cagatgtctg       1020

tcccagagca gaaacctgct gaagaccaca gacgacatgg tgaagacagc cagagagaag       1080

ctgaagcact acagctgcac cgccgaggac atcgaccacg aggatatcac aagagaccag       1140

acatccaccc tgaagacatg tctgcctctg gagctgcaca agaatgagtc ctgcctggcc       1200

accagagaga cctccagcac caccaggggc agctgcctgc cccctcagaa gacctccctg       1260

atgatgacac tgtgcctggg cagcatctac gaggacctga agatgtacca gaccgagttc       1320

caggccatca atgccgccct gcagaaccac aaccaccagc agatcatcct ggataagggc       1380

atgctggtgg ccatcgacga gctgatgcag agcctgaacc acaatggcga gaccctgagg       1440

cagaagcctc ctgtgggcga ggccgatccc tacagagtga agatgaagct gtgtatcctg       1500

ctgcacgcct tttccacaag ggtggtgacc atcaacaggg tcatgggcta cctgtccagc       1560

gccggcggcg gcggcagcgg aggaggaggc tccgagccac gcggccccac aatcaagcca       1620

tgcccccctt gcaagtgtcc tgcaccaaat ctgctgggag gaccatccgt gttcatcttt       1680

ccacccaaga tcaaggacgt gctgatgatc agcctgtccc caatcgtgac ctgcgtggtc       1740

gtggacgtga gcgaggacga tcctgatgtg cagatctcct ggttcgtgaa caatgtggag       1800

gtgcacaccg cccagaccca gacacaccgg gaggactaca actccacact gagagtggtg       1860

tctgccctgc ccatccagca ccaggactgg atgagcggca aggagtttaa gtgcaaggtg       1920

aacaataagg atctgcccgc ccctatcgag cggacaatct ctaagcctaa gggcagcgtg       1980

agagccccac aggtgtatgt gctgcctcca cccgaggagg agatgaccaa gaagcaggtg       2040

acactgtctt gtgccgtgac cgacttcatg cctgaggata tctatgtgga gtggaccaac       2100

aatggcaaga cagagctgaa ctacaagaat acagagccag tgctggactc cgatggctct       2160

tacttcatgg tgagcaagct gagggtggag aagaagaact gggtggagcg caattcttac       2220

agctgctccg tggtgcacga gggcctgcac aaccaccaca ccacaaagtc ttttagccgg       2280

acccctggca ag                                                           2292


<210>    68
<211>    2292
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2-mu IgG2a Fc hole


<400>    68
atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg attggacacc tgacgccccc         60

ggcgagacag tgaacctgac atgcgatacc cctgaggagg atgatatcac atggacctcc        120

gatcagagac acggcgtgat cggcagcggc aagaccctga caatcaccgt gaaggagttt        180

ctggatgccg gccagtacac ctgtcacaag ggcggcgaga cactgagcca ctcccacctg        240

ctgctgcaca agaaggagaa tggcatctgg tccaccgaga tcctgaagaa cttcaagaac        300

aagaccttcc tgaagtgtga ggcccctaat tactccggca ggtttacatg ctcctggctg        360

gtgcagagaa acatggacct gaagtttaat atcaagagct cctcctccag ccccgatagc        420

agagccgtga cctgtggcat ggccagcctg agcgccgaga aggtgaccct ggatcagagg        480

gattacgaga agtactccgt gtcctgtcag gaggatgtga catgtcctac agccgaggag        540

acactgccta tcgagctggc cctggaggcc aggcagcaga ataagtacga gaactacagc        600

acaagctttt tcatcaggga catcatcaag cccgatcccc ccaagaacct gcagatgaag        660

cccctgaaga acagccaggt ggaggtgtcc tgggagtacc ctgatagctg gtccacccct        720

cactcctact tctccctgaa gttctttgtg agaatccagg ccgccgctga gaagatggcc        780

gagacagagg agggctgcaa tcagaagggc gccttcctgg tggagaagac atccaccgag        840

gtgcagtgta agggcggcaa cgtgtgcgtg caggcccagg acagatacta caattccagc        900

tgtagcaagt gggcctgtgt gccttgtaga gtgagatccg gcggcggcgg ctccggagga        960

ggaggaagcg gaggaggcgg ctccagagtg atccctgtgt ccggccctgc cagatgtctg       1020

tcccagagca gaaacctgct gaagaccaca gacgacatgg tgaagacagc cagagagaag       1080

ctgaagcact acagctgcac cgccgaggac atcgaccacg aggatatcac aagagaccag       1140

acatccaccc tgaagacatg tctgcctctg gagctgcaca agaatgagtc ctgcctggcc       1200

accagagaga cctccagcac caccaggggc agctgcctgc cccctcagaa gacctccctg       1260

atgatgacac tgtgcctggg cagcatctac gaggacctga agatgtacca gaccgagttc       1320

caggccatca atgccgccct gcagaaccac aaccaccagc agatcatcct ggataagggc       1380

atgctggtgg ccatcgacga gctgatgcag agcctgaacc acaatggcga gaccctgagg       1440

cagaagcctc ctgtgggcga ggccgatccc tacagagtga agatgaagct gtgtatcctg       1500

ctgcacgcct tttccacaag ggtggtgacc atcaacaggg tcatgggcta cctgtccagc       1560

gccggcggcg gcggcagcgg aggaggaggc tccgagccac gcggccccac aatcaagcca       1620

tgcccccctt gcaagtgtcc tgcaccaaat ctgctgggag gaccatccgt gttcatcttt       1680

ccacccaaga tcaaggacgt gctgatgatc agcctgtccc caatcgtgac ctgcgtggtc       1740

gtggacgtga gcgaggacga tcctgatgtg cagatctcct ggttcgtgaa caatgtggag       1800

gtgcacaccg cccagaccca gacacaccgg gaggactaca actccacact gagagtggtg       1860

tctgccctgc ccatccagca ccaggactgg atgagcggca aggagtttaa gtgcaaggtg       1920

aacaataagg atctgcccgc ccctatcgag cggacaatct ctaagcctaa gggcagcgtg       1980

agagccccac aggtgtatgt gctgcctcca cccgaggagg agatgaccaa gaagcaggtg       2040

acactgtctt gtgccgtgac cgacttcatg cctgaggata tctatgtgga gtggaccaac       2100

aatggcaaga cagagctgaa ctacaagaat acagagccag tgctggactc cgatggctct       2160

tacttcatgg tgagcaagct gagggtggag aagaagaact gggtggagcg caattcttac       2220

agctgctccg tggtgcacga gggcctgcac aaccaccaca ccacaaagtc ttttagccgg       2280

acccctggca ag                                                           2292


<210>    69
<211>    1761
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (anti-mu CD20 VH)2-mu IgG2a Fc knob


<400>    69
caagtgcagc tgcagcaacc tggtgctgag ctggtgcgcc ccggcacaag cgtgaagctc         60

agctgcaagg cctccggata caccttcact agctactgga tgcactggat taaacagcgg        120

cctggccagg gcctggaatg gatcggcgtg atcgatccca gcgacaacta cacaaagtac        180

aaccagaagt tcaagggcaa ggccacactg acagtggaca ccagcagctc caccgcctat        240

atgcagctga gctccctgac cagcgaggat tctgccgtgt acttctgcgc cagagagggc        300

tactacggct ccagcccttg gttcgcctac tggggccagg gcaccctggt caccgtgtcc        360

tccggcggcg gcggaagcgg cggcggcggc agcggaggag gcggaagcca ggtgcagctg        420

cagcagccag gagcagagct ggtgaggcca ggcacctctg tgaagctgag ctgcaaggcc        480

tccggctaca ccttcacatc ttattggatg cactggatca agcagaggcc aggacaggga        540

ctggagtgga tcggcgtgat cgacccctcc gataactaca ccaagtacaa ccagaagttt        600

aagggcaagg ccaccctgac agtggacacc agctcctcta cagcctacat gcagctgagc        660

tccctgacat ccgaggattc tgccgtgtat ttctgtgccc gggagggcta ctatggctct        720

agcccatggt ttgcctactg gggccagggc accctggtga cagtgtcctc tgccaagacc        780

acagccccca gcgtgtatcc tctggcccca gtgtgcggcg ataccacagg cagctccgtg        840

accctgggct gtctggtgaa gggctacttc cctgagccag tgaccctgac atggaactct        900

ggcagcctgt ctagcggagt gcacaccttt ccagccgtgc tgcagtccga tctgtataca        960

ctgtcctcta gcgtgaccgt gacatcctct acctggccct cccagtctat cacatgcaac       1020

gtggcccacc ctgccagctc caccaaggtg gacaagaaga tcgagccccg gggccctaca       1080

atcaagccat gtccaccttg caagtgtcca gcacctaatc tgctgggagg acctagcgtg       1140

ttcatctttc cacccaagat caaggacgtg ctgatgatca gcctgtcccc tatcgtgacc       1200

tgcgtggtgg tggacgtgag cgaggacgat ccagatgtgc agatctcctg gttcgtgaac       1260

aatgtggagg tgcacaccgc ccagacccag acacaccggg aggactacaa ctccacactg       1320

agagtggtgt ctgccctgcc tatccagcac caggactgga tgtccggcaa ggagtttaag       1380

tgcaaggtga acaataagga tctgccagcc cccatcgagc ggaccatctc taagcctaag       1440

ggcagcgtga gagccccaca ggtgtatgtg ctgcctccac ccgaggagga gatgaccaag       1500

aagcaggtga cactgtggtg tatggtgacc gacttcatgc ctgaggatat ctacgtggag       1560

tggaccaaca atggcaagac agagctgaac tataagaata cagagccagt gctggacagc       1620

gatggctcct actttatgta tagcaagctg agggtggaga agaagaactg ggtggagcgc       1680

aattcttaca gctgttccgt ggtgcacgag ggcctgcaca atcaccacac cacaaagtct       1740

ttcagcagaa cccccggcaa g                                                 1761


<210>    70
<211>    1002
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (anti-mu CD20 VL)2


<400>    70
cagatcgtga tgagccagag ccccgccatc ctgtctgcta gtcctggcga gaaggtgaca         60

atgacctgta gagcccggag cagcgtttct tatatccact ggtaccagca gaaacccggc        120

tcttctccaa agccttggat ctacgccacc agcaatctgg ccagcggagt gccaggtaga        180

ttcagcggca gcggaagcgg aacctcttac agcctgacca tcaccagagt ggaagccgag        240

gacgccgcta catactactg ccagcagtgg agcagcaaac ctcctacctt tggcggcggc        300

accaagctgg aaatcaaggg cggcggaggc tctggcggag ggggcagcgg cggcggcggc        360

agtcagatcg tgatgtccca gtctccagca atcctgagcg cctcccctgg agagaaggtg        420

accatgacat gccgggccag aagctccgtg agctacatcc actggtatca gcagaagcca        480

ggctctagcc ctaagccatg gatctacgcc accagcaacc tggcatccgg agtgccaggc        540

cggttctctg gcagcggctc cggcacatct tatagcctga ccatcacaag agtggaggcc        600

gaggacgccg ccacctacta ttgccagcag tggtcctcta agccccctac attcggcggc        660

ggcaccaagc tggagatcaa gaggactgat gcagcaccta cagtgtccat ctttccaccc        720

agctccgagc agctgacctc tggaggagca agcgtggtgt gcttcctgaa caacttctac        780

ccaaaggaca tcaacgtgaa gtggaagatc gatggctccg agcggcagaa cggcgtgctg        840

aacagctgga cagaccagga tagcaaggac tccacctatt ctatgtctag caccctgaca        900

ctgaccaagg atgagtacga gaggcacaat agctatacat gcgaggccac ccacaagaca        960

tccacctctc ccatcgtgaa gtcctttaac cgcaatgagt gt                          1002


<210>    71
<211>    2139
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc knob-anti-mu CD20 scFv


<400>    71
caggtgcagc tgcagcagcc aggagcagag ctggtgaggc caggcacctc tgtgaagctg         60

agctgcaagg cctccggcta caccttcaca tcttattgga tgcactggat caagcagagg        120

ccaggacagg gactggagtg gatcggcgtg atcgacccct ccgataacta caccaagtac        180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca ccagctcctc tacagcctac        240

atgcagctga gctccctgac atccgaggat tctgccgtgt atttctgtgc ccgggagggc        300

tactatggct ctagcccatg gtttgcctac tggggccagg gcaccctggt gacagtgtcc        360

tctgccaaga ccacagcccc cagcgtgtat cctctggccc cagtgtgcgg cgataccaca        420

ggcagctccg tgaccctggg ctgtctggtg aagggctact tccctgagcc agtgaccctg        480

acatggaact ctggcagcct gtctagcgga gtgcacacct ttccagccgt gctgcagtcc        540

gatctgtata cactgtcctc tagcgtgacc gtgacatcct ctacctggcc ctcccagtct        600

atcacatgca acgtggccca ccctgccagc tccaccaagg tggacaagaa gatcgagccc        660

cggggcccta caatcaagcc atgtccacct tgcaagtgtc cagcacctaa tctgctggga        720

ggacctagcg tgttcatctt tccacccaag atcaaggacg tgctgatgat cagcctgtcc        780

cctatcgtga cctgcgtggt ggtggacgtg agcgaggacg atccagatgt gcagatctcc        840

tggttcgtga acaatgtgga ggtgcacacc gcccagaccc agacacaccg ggaggactac        900

aactccacac tgagagtggt gtctgccctg cctatccagc accaggactg gatgtccggc        960

aaggagttta agtgcaaggt gaacaataag gatctgccag cccccatcga gcggaccatc       1020

tctaagccta agggcagcgt gagagcccca caggtgtatg tgctgcctcc acccgaggag       1080

gagatgacca agaagcaggt gacactgtgg tgtatggtga ccgacttcat gcctgaggat       1140

atctacgtgg agtggaccaa caatggcaag acagagctga actataagaa tacagagcca       1200

gtgctggaca gcgatggctc ctactttatg tatagcaagc tgagggtgga gaagaagaac       1260

tgggtggagc gcaattctta cagctgttcc gtggtgcacg agggcctgca caatcaccac       1320

accacaaagt ctttcagcag aacccccggc aagggcggcg gaggctctgg cggagggggc       1380

agcggcggcg gcggcagtca agtgcagctg cagcaacctg gtgctgagct ggtgcgcccc       1440

ggcacaagcg tgaagctcag ctgcaaggcc tccggataca ccttcactag ctactggatg       1500

cactggatta aacagcggcc tggccagggc ctggaatgga tcggcgtgat cgatcccagc       1560

gacaactaca caaagtacaa ccagaagttc aagggcaagg ccacactgac agtggacacc       1620

agcagctcca ccgcctatat gcagctgagc tccctgacca gcgaggattc tgccgtgtac       1680

ttctgcgcca gagagggcta ctacggctcc agcccttggt tcgcctactg gggccagggc       1740

accctggtca ccgtgtcctc cggcggcggc ggaagcggcg gcggcggcag cggaggaggc       1800

ggaagcggcg gcggcggatc tcagatcgtg atgagccaga gccccgccat cctgtctgct       1860

agtcctggcg agaaggtgac aatgacctgt agagcccgga gcagcgtttc ttatatccac       1920

tggtaccagc agaaacccgg ctcttctcca aagccttgga tctacgccac cagcaatctg       1980

gccagcggag tgccaggtag attcagcggc agcggaagcg gaacctctta cagcctgacc       2040

atcaccagag tggaagccga ggacgccgct acatactact gccagcagtg gagcagcaaa       2100

cctcctacct ttggcggcgg caccaagctg gaaatcaag                              2139


<210>    72
<211>    1425
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LC-anti-mu CD20 scFv


<400>    72
cagatcgtga tgtcccagtc tccagcaatc ctgagcgcct cccctggaga gaaggtgacc         60

atgacatgcc gggccagaag ctccgtgagc tacatccact ggtatcagca gaagccaggc        120

tctagcccta agccatggat ctacgccacc agcaacctgg catccggagt gccaggccgg        180

ttctctggca gcggctccgg cacatcttat agcctgacca tcacaagagt ggaggccgag        240

gacgccgcca cctactattg ccagcagtgg tcctctaagc cccctacatt cggcggcggc        300

accaagctgg agatcaagag gactgatgca gcacctacag tgtccatctt tccacccagc        360

tccgagcagc tgacctctgg aggagcaagc gtggtgtgct tcctgaacaa cttctaccca        420

aaggacatca acgtgaagtg gaagatcgat ggctccgagc ggcagaacgg cgtgctgaac        480

agctggacag accaggatag caaggactcc acctattcta tgtctagcac cctgacactg        540

accaaggatg agtacgagag gcacaatagc tatacatgcg aggccaccca caagacatcc        600

acctctccca tcgtgaagtc ctttaaccgc aatgagtgtg gcggcggagg ctctggcgga        660

gggggcagcg gcggcggcgg cagtcaagtg cagctgcagc aacctggtgc tgagctggtg        720

cgccccggca caagcgtgaa gctcagctgc aaggcctccg gatacacctt cactagctac        780

tggatgcact ggattaaaca gcggcctggc cagggcctgg aatggatcgg cgtgatcgat        840

cccagcgaca actacacaaa gtacaaccag aagttcaagg gcaaggccac actgacagtg        900

gacaccagca gctccaccgc ctatatgcag ctgagctccc tgaccagcga ggattctgcc        960

gtgtacttct gcgccagaga gggctactac ggctccagcc cttggttcgc ctactggggc       1020

cagggcaccc tggtcaccgt gtcctccggc ggcggcggaa gcggcggcgg cggcagcgga       1080

ggaggcggaa gcggcggcgg cggatctcag atcgtgatga gccagagccc cgccatcctg       1140

tctgctagtc ctggcgagaa ggtgacaatg acctgtagag cccggagcag cgtttcttat       1200

atccactggt accagcagaa acccggctct tctccaaagc cttggatcta cgccaccagc       1260

aatctggcca gcggagtgcc aggtagattc agcggcagcg gaagcggaac ctcttacagc       1320

ctgaccatca ccagagtgga agccgaggac gccgctacat actactgcca gcagtggagc       1380

agcaaacctc ctacctttgg cggcggcacc aagctggaaa tcaag                       1425


<210>    73
<211>    2961
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc hole-mu scIL-12


<400>    73
caggtgcagc tgcagcagcc aggagcagag ctggtgaggc caggcacctc tgtgaagctg         60

agctgcaagg cctccggcta caccttcaca tcttattgga tgcactggat caagcagagg        120

ccaggacagg gactggagtg gatcggcgtg atcgacccct ccgataacta caccaagtac        180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca ccagctcctc tacagcctac        240

atgcagctga gctccctgac atccgaggat tctgccgtgt atttctgtgc ccgggagggc        300

tactatggct ctagcccatg gtttgcctac tggggccagg gcaccctggt gacagtgtcc        360

tctgccaaga ccacagcccc cagcgtgtat cctctggccc cagtgtgcgg cgataccaca        420

ggcagctccg tgaccctggg ctgtctggtg aagggctact tccctgagcc agtgaccctg        480

acatggaact ctggcagcct gtctagcgga gtgcacacct ttccagccgt gctgcagtcc        540

gatctgtata cactgtcctc tagcgtgacc gtgacatcct ctacctggcc ctcccagtct        600

atcacatgca acgtggccca ccctgccagc tccaccaagg tggacaagaa gatcgagcca        660

cgcggcccca caatcaagcc atgcccccct tgcaagtgtc ctgcaccaaa tctgctggga        720

ggaccatccg tgttcatctt tccacccaag atcaaggacg tgctgatgat cagcctgtcc        780

ccaatcgtga cctgcgtggt cgtggacgtg agcgaggacg atcctgatgt gcagatctcc        840

tggttcgtga acaatgtgga ggtgcacacc gcccagaccc agacacaccg ggaggactac        900

aactccacac tgagagtggt gtctgccctg cccatccagc accaggactg gatgagcggc        960

aaggagttta agtgcaaggt gaacaataag gatctgcccg cccctatcga gcggacaatc       1020

tctaagccta agggcagcgt gagagcccca caggtgtatg tgctgcctcc acccgaggag       1080

gagatgacca agaagcaggt gacactgtct tgtgccgtga ccgacttcat gcctgaggat       1140

atctatgtgg agtggaccaa caatggcaag acagagctga actacaagaa tacagagcca       1200

gtgctggact ccgatggctc ttacttcatg gtgagcaagc tgagggtgga gaagaagaac       1260

tgggtggagc gcaattctta cagctgctcc gtggtgcacg agggcctgca caaccaccac       1320

accacaaagt cttttagccg gacccctggc aagggtggag gtggctcagg aggaggcggt       1380

tctggcggag gaggtagtat gtgggagctg gagaaggacg tgtacgtggt ggaggtggat       1440

tggacacctg acgcccccgg cgagacagtg aacctgacat gcgatacccc tgaggaggat       1500

gatatcacat ggacctccga tcagagacac ggcgtgatcg gcagcggcaa gaccctgaca       1560

atcaccgtga aggagtttct ggatgccggc cagtacacct gtcacaaggg cggcgagaca       1620

ctgagccact cccacctgct gctgcacaag aaggagaatg gcatctggtc caccgagatc       1680

ctgaagaact tcaagaacaa gaccttcctg aagtgtgagg cccctaatta ctccggcagg       1740

tttacatgct cctggctggt gcagagaaac atggacctga agtttaatat caagagctcc       1800

tcctccagcc ccgatagcag agccgtgacc tgtggcatgg ccagcctgag cgccgagaag       1860

gtgaccctgg atcagaggga ttacgagaag tactccgtgt cctgtcagga ggatgtgaca       1920

tgtcctacag ccgaggagac actgcctatc gagctggccc tggaggccag gcagcagaat       1980

aagtacgaga actacagcac aagctttttc atcagggaca tcatcaagcc cgatcccccc       2040

aagaacctgc agatgaagcc cctgaagaac agccaggtgg aggtgtcctg ggagtaccct       2100

gatagctggt ccacccctca ctcctacttc tccctgaagt tctttgtgag aatccagaga       2160

aagaaggaga agatgaagga gacagaggag ggctgcaatc agaagggcgc cttcctggtg       2220

gagaagacat ccaccgaggt gcagtgtaag ggcggcaacg tgtgcgtgca ggcccaggac       2280

agatactaca attccagctg tagcaagtgg gcctgtgtgc cttgtagagt gagatccggc       2340

ggcggcggct ccggaggagg aggaagcgga ggaggcggct ccagagtgat ccctgtgtcc       2400

ggccctgcca gatgtctgtc ccagagcaga aacctgctga agaccacaga cgacatggtg       2460

aagacagcca gagagaagct gaagcactac agctgcaccg ccgaggacat cgaccacgag       2520

gatatcacaa gagaccagac atccaccctg aagacatgtc tgcctctgga gctgcacaag       2580

aatgagtcct gcctggccac cagagagacc tccagcacca ccaggggcag ctgcctgccc       2640

cctcagaaga cctccctgat gatgacactg tgcctgggca gcatctacga ggacctgaag       2700

atgtaccaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa ccaccagcag       2760

atcatcctgg ataagggcat gctggtggcc atcgacgagc tgatgcagag cctgaaccac       2820

aatggcgaga ccctgaggca gaagcctcct gtgggcgagg ccgatcccta cagagtgaag       2880

atgaagctgt gtatcctgct gcacgccttt tccacaaggg tggtgaccat caacagggtc       2940

atgggctacc tgtccagcgc c                                                 2961


<210>    74
<211>    2961
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc hole-mu scIL-12 mut2


<400>    74
caggtgcagc tgcagcagcc aggagcagag ctggtgaggc caggcacctc tgtgaagctg         60

agctgcaagg cctccggcta caccttcaca tcttattgga tgcactggat caagcagagg        120

ccaggacagg gactggagtg gatcggcgtg atcgacccct ccgataacta caccaagtac        180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca ccagctcctc tacagcctac        240

atgcagctga gctccctgac atccgaggat tctgccgtgt atttctgtgc ccgggagggc        300

tactatggct ctagcccatg gtttgcctac tggggccagg gcaccctggt gacagtgtcc        360

tctgccaaga ccacagcccc cagcgtgtat cctctggccc cagtgtgcgg cgataccaca        420

ggcagctccg tgaccctggg ctgtctggtg aagggctact tccctgagcc agtgaccctg        480

acatggaact ctggcagcct gtctagcgga gtgcacacct ttccagccgt gctgcagtcc        540

gatctgtata cactgtcctc tagcgtgacc gtgacatcct ctacctggcc ctcccagtct        600

atcacatgca acgtggccca ccctgccagc tccaccaagg tggacaagaa gatcgagcca        660

cgcggcccca caatcaagcc atgcccccct tgcaagtgtc ctgcaccaaa tctgctggga        720

ggaccatccg tgttcatctt tccacccaag atcaaggacg tgctgatgat cagcctgtcc        780

ccaatcgtga cctgcgtggt cgtggacgtg agcgaggacg atcctgatgt gcagatctcc        840

tggttcgtga acaatgtgga ggtgcacacc gcccagaccc agacacaccg ggaggactac        900

aactccacac tgagagtggt gtctgccctg cccatccagc accaggactg gatgagcggc        960

aaggagttta agtgcaaggt gaacaataag gatctgcccg cccctatcga gcggacaatc       1020

tctaagccta agggcagcgt gagagcccca caggtgtatg tgctgcctcc acccgaggag       1080

gagatgacca agaagcaggt gacactgtct tgtgccgtga ccgacttcat gcctgaggat       1140

atctatgtgg agtggaccaa caatggcaag acagagctga actacaagaa tacagagcca       1200

gtgctggact ccgatggctc ttacttcatg gtgagcaagc tgagggtgga gaagaagaac       1260

tgggtggagc gcaattctta cagctgctcc gtggtgcacg agggcctgca caaccaccac       1320

accacaaagt cttttagccg gacccctggc aagggtggag gtggctcagg aggaggcggt       1380

tctggcggag gaggtagtat gtgggagctg gagaaggacg tgtacgtggt ggaggtggat       1440

tggacacctg acgcccccgg cgagacagtg aacctgacat gcgatacccc tgaggaggat       1500

gatatcacat ggacctccga tcagagacac ggcgtgatcg gcagcggcaa gaccctgaca       1560

atcaccgtga aggagtttct ggatgccggc cagtacacct gtcacaaggg cggcgagaca       1620

ctgagccact cccacctgct gctgcacaag aaggagaatg gcatctggtc caccgagatc       1680

ctgaagaact tcaagaacaa gaccttcctg aagtgtgagg cccctaatta ctccggcagg       1740

tttacatgct cctggctggt gcagagaaac atggacctga agtttaatat caagagctcc       1800

tcctccagcc ccgatagcag agccgtgacc tgtggcatgg ccagcctgag cgccgagaag       1860

gtgaccctgg atcagaggga ttacgagaag tactccgtgt cctgtcagga ggatgtgaca       1920

tgtcctacag ccgaggagac actgcctatc gagctggccc tggaggccag gcagcagaat       1980

aagtacgaga actacagcac aagctttttc atcagggaca tcatcaagcc cgatcccccc       2040

aagaacctgc agatgaagcc cctgaagaac agccaggtgg aggtgtcctg ggagtaccct       2100

gatagctggt ccacccctca ctcctacttc tccctgaagt tctttgtgag aatccaggct       2160

gccgccgaga agatggccga gacagaggag ggctgcaatc agaagggcgc cttcctggtg       2220

gagaagacat ccaccgaggt gcagtgtaag ggcggcaacg tgtgcgtgca ggcccaggac       2280

agatactaca attccagctg tagcaagtgg gcctgtgtgc cttgtagagt gagatccggc       2340

ggcggcggct ccggaggagg aggaagcgga ggaggcggct ccagagtgat ccctgtgtcc       2400

ggccctgcca gatgtctgtc ccagagcaga aacctgctga agaccacaga cgacatggtg       2460

aagacagcca gagagaagct gaagcactac agctgcaccg ccgaggacat cgaccacgag       2520

gatatcacaa gagaccagac atccaccctg aagacatgtc tgcctctgga gctgcacaag       2580

aatgagtcct gcctggccac cagagagacc tccagcacca ccaggggcag ctgcctgccc       2640

cctcagaaga cctccctgat gatgacactg tgcctgggca gcatctacga ggacctgaag       2700

atgtaccaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa ccaccagcag       2760

atcatcctgg ataagggcat gctggtggcc atcgacgagc tgatgcagag cctgaaccac       2820

aatggcgaga ccctgaggca gaagcctcct gtgggcgagg ccgatcccta cagagtgaag       2880

atgaagctgt gtatcctgct gcacgccttt tccacaaggg tggtgaccat caacagggtc       2940

atgggctacc tgtccagcgc c                                                 2961


<210>    75
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc knob DANG


<400>    75
caggtgcagc tgcagcagcc aggagcagag ctggtgaggc caggcacctc tgtgaagctg         60

agctgcaagg cctccggcta caccttcaca tcttattgga tgcactggat caagcagagg        120

ccaggacagg gactggagtg gatcggcgtg atcgacccct ccgataacta caccaagtac        180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca ccagctcctc tacagcctac        240

atgcagctga gctccctgac atccgaggat tctgccgtgt atttctgtgc ccgggagggc        300

tactatggct ctagcccatg gtttgcctac tggggccagg gcaccctggt gacagtgtcc        360

tctgccaaga ccacagcccc cagcgtgtat cctctggccc cagtgtgcgg cgataccaca        420

ggcagctccg tgaccctggg ctgtctggtg aagggctact tccctgagcc agtgaccctg        480

acatggaact ctggcagcct gtctagcgga gtgcacacct ttccagccgt gctgcagtcc        540

gatctgtata cactgtcctc tagcgtgacc gtgacatcct ctacctggcc ctcccagtct        600

atcacatgca acgtggccca ccctgccagc tccaccaagg tggacaagaa gatcgagccc        660

cggggcccta caatcaagcc atgtccacct tgcaagtgtc cagcacctaa tctgctggga        720

ggacctagcg tgttcatctt tccacccaag atcaaggacg tgctgatgat cagcctgtcc        780

cctatcgtga cctgcgtggt ggtggccgtg agcgaggacg atccagatgt gcagatctcc        840

tggttcgtga acaatgtgga ggtgcacacc gcccagaccc agacacaccg ggaggactac        900

ggctccacac tgagagtggt gtctgccctg cctatccagc accaggactg gatgtccggc        960

aaggagttta agtgcaaggt gaacaataag gatctgccag cccccatcga gcggaccatc       1020

tctaagccta agggcagcgt gagagcccca caggtgtatg tgctgcctcc acccgaggag       1080

gagatgacca agaagcaggt gacactgtgg tgtatggtga ccgacttcat gcctgaggat       1140

atctacgtgg agtggaccaa caatggcaag acagagctga actataagaa tacagagcca       1200

gtgctggaca gcgatggctc ctactttatg tatagcaagc tgagggtgga gaagaagaac       1260

tgggtggagc gcaattctta cagctgttcc gtggtgcacg agggcctgca caatcaccac       1320

accacaaagt ctttcagcag aacccccggc aag                                    1353


<210>    76
<211>    2292
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu scIL-12-mu IgG2a Fc hole DANG


<400>    76
atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg attggacacc tgacgccccc         60

ggcgagacag tgaacctgac atgcgatacc cctgaggagg atgatatcac atggacctcc        120

gatcagagac acggcgtgat cggcagcggc aagaccctga caatcaccgt gaaggagttt        180

ctggatgccg gccagtacac ctgtcacaag ggcggcgaga cactgagcca ctcccacctg        240

ctgctgcaca agaaggagaa tggcatctgg tccaccgaga tcctgaagaa cttcaagaac        300

aagaccttcc tgaagtgtga ggcccctaat tactccggca ggtttacatg ctcctggctg        360

gtgcagagaa acatggacct gaagtttaat atcaagagct cctcctccag ccccgatagc        420

agagccgtga cctgtggcat ggccagcctg agcgccgaga aggtgaccct ggatcagagg        480

gattacgaga agtactccgt gtcctgtcag gaggatgtga catgtcctac agccgaggag        540

acactgccta tcgagctggc cctggaggcc aggcagcaga ataagtacga gaactacagc        600

acaagctttt tcatcaggga catcatcaag cccgatcccc ccaagaacct gcagatgaag        660

cccctgaaga acagccaggt ggaggtgtcc tgggagtacc ctgatagctg gtccacccct        720

cactcctact tctccctgaa gttctttgtg agaatccaga gaaagaagga gaagatgaag        780

gagacagagg agggctgcaa tcagaagggc gccttcctgg tggagaagac atccaccgag        840

gtgcagtgta agggcggcaa cgtgtgcgtg caggcccagg acagatacta caattccagc        900

tgtagcaagt gggcctgtgt gccttgtaga gtgagatccg gcggcggcgg ctccggagga        960

ggaggaagcg gaggaggcgg ctccagagtg atccctgtgt ccggccctgc cagatgtctg       1020

tcccagagca gaaacctgct gaagaccaca gacgacatgg tgaagacagc cagagagaag       1080

ctgaagcact acagctgcac cgccgaggac atcgaccacg aggatatcac aagagaccag       1140

acatccaccc tgaagacatg tctgcctctg gagctgcaca agaatgagtc ctgcctggcc       1200

accagagaga cctccagcac caccaggggc agctgcctgc cccctcagaa gacctccctg       1260

atgatgacac tgtgcctggg cagcatctac gaggacctga agatgtacca gaccgagttc       1320

caggccatca atgccgccct gcagaaccac aaccaccagc agatcatcct ggataagggc       1380

atgctggtgg ccatcgacga gctgatgcag agcctgaacc acaatggcga gaccctgagg       1440

cagaagcctc ctgtgggcga ggccgatccc tacagagtga agatgaagct gtgtatcctg       1500

ctgcacgcct tttccacaag ggtggtgacc atcaacaggg tcatgggcta cctgtccagc       1560

gccggcggcg gcggcagcgg aggaggaggc tccgagccac gcggccccac aatcaagcca       1620

tgcccccctt gcaagtgtcc tgcaccaaat ctgctgggag gaccatccgt gttcatcttt       1680

ccacccaaga tcaaggacgt gctgatgatc agcctgtccc caatcgtgac ctgcgtggtc       1740

gtggccgtga gcgaggacga tcctgatgtg cagatctcct ggttcgtgaa caatgtggag       1800

gtgcacaccg cccagaccca gacacaccgg gaggactacg gctccacact gagagtggtg       1860

tctgccctgc ccatccagca ccaggactgg atgagcggca aggagtttaa gtgcaaggtg       1920

aacaataagg atctgcccgc ccctatcgag cggacaatct ctaagcctaa gggcagcgtg       1980

agagccccac aggtgtatgt gctgcctcca cccgaggagg agatgaccaa gaagcaggtg       2040

acactgtctt gtgccgtgac cgacttcatg cctgaggata tctatgtgga gtggaccaac       2100

aatggcaaga cagagctgaa ctacaagaat acagagccag tgctggactc cgatggctct       2160

tacttcatgg tgagcaagct gagggtggag aagaagaact gggtggagcg caattcttac       2220

agctgctccg tggtgcacga gggcctgcac aaccaccaca ccacaaagtc ttttagccgg       2280

acccctggca ag                                                           2292


<210>    77
<211>    2292
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut1-mu IgG2a Fc hole DANG


<400>    77
atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg attggacacc tgacgccccc         60

ggcgagacag tgaacctgac atgcgatacc cctgaggagg atgatatcac atggacctcc        120

gatcagagac acggcgtgat cggcagcggc aagaccctga caatcaccgt gaaggagttt        180

ctggatgccg gccagtacac ctgtcacaag ggcggcgaga cactgagcca ctcccacctg        240

ctgctgcaca agaaggagaa tggcatctgg tccaccgaga tcctgaagaa cttcaagaac        300

aagaccttcc tgaagtgtga ggcccctaat tactccggca ggtttacatg ctcctggctg        360

gtgcagagaa acatggacct gaagtttaat atcaagagct cctcctccag ccccgatagc        420

agagccgtga cctgtggcat ggccagcctg agcgccgaga aggtgaccct ggatcagagg        480

gattacgaga agtactccgt gtcctgtcag gaggatgtga catgtcctac agccgaggag        540

acactgccta tcgagctggc cctggaggcc aggcagcaga ataagtacga gaactacagc        600

acaagctttt tcatcaggga catcatcaag cccgatcccc ccaagaacct gcagatgaag        660

cccctgaaga acagccaggt ggaggtgtcc tgggagtacc ctgatagctg gtccacccct        720

cactcctact tctccctgaa gttctttgtg agaatccaga gagccaagga gaagatggcc        780

gagacagagg agggctgcaa tcagaagggc gccttcctgg tggagaagac atccaccgag        840

gtgcagtgta agggcggcaa cgtgtgcgtg caggcccagg acagatacta caattccagc        900

tgtagcaagt gggcctgtgt gccttgtaga gtgagatccg gcggcggcgg ctccggagga        960

ggaggaagcg gaggaggcgg ctccagagtg atccctgtgt ccggccctgc cagatgtctg       1020

tcccagagca gaaacctgct gaagaccaca gacgacatgg tgaagacagc cagagagaag       1080

ctgaagcact acagctgcac cgccgaggac atcgaccacg aggatatcac aagagaccag       1140

acatccaccc tgaagacatg tctgcctctg gagctgcaca agaatgagtc ctgcctggcc       1200

accagagaga cctccagcac caccaggggc agctgcctgc cccctcagaa gacctccctg       1260

atgatgacac tgtgcctggg cagcatctac gaggacctga agatgtacca gaccgagttc       1320

caggccatca atgccgccct gcagaaccac aaccaccagc agatcatcct ggataagggc       1380

atgctggtgg ccatcgacga gctgatgcag agcctgaacc acaatggcga gaccctgagg       1440

cagaagcctc ctgtgggcga ggccgatccc tacagagtga agatgaagct gtgtatcctg       1500

ctgcacgcct tttccacaag ggtggtgacc atcaacaggg tcatgggcta cctgtccagc       1560

gccggcggcg gcggcagcgg aggaggaggc tccgagccac gcggccccac aatcaagcca       1620

tgcccccctt gcaagtgtcc tgcaccaaat ctgctgggag gaccatccgt gttcatcttt       1680

ccacccaaga tcaaggacgt gctgatgatc agcctgtccc caatcgtgac ctgcgtggtc       1740

gtggccgtga gcgaggacga tcctgatgtg cagatctcct ggttcgtgaa caatgtggag       1800

gtgcacaccg cccagaccca gacacaccgg gaggactacg gctccacact gagagtggtg       1860

tctgccctgc ccatccagca ccaggactgg atgagcggca aggagtttaa gtgcaaggtg       1920

aacaataagg atctgcccgc ccctatcgag cggacaatct ctaagcctaa gggcagcgtg       1980

agagccccac aggtgtatgt gctgcctcca cccgaggagg agatgaccaa gaagcaggtg       2040

acactgtctt gtgccgtgac cgacttcatg cctgaggata tctatgtgga gtggaccaac       2100

aatggcaaga cagagctgaa ctacaagaat acagagccag tgctggactc cgatggctct       2160

tacttcatgg tgagcaagct gagggtggag aagaagaact gggtggagcg caattcttac       2220

agctgctccg tggtgcacga gggcctgcac aaccaccaca ccacaaagtc ttttagccgg       2280

acccctggca ag                                                           2292


<210>    78
<211>    2292
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2-mu IgG2a Fc


<400>    78
atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg attggacacc tgacgccccc         60

ggcgagacag tgaacctgac atgcgatacc cctgaggagg atgatatcac atggacctcc        120

gatcagagac acggcgtgat cggcagcggc aagaccctga caatcaccgt gaaggagttt        180

ctggatgccg gccagtacac ctgtcacaag ggcggcgaga cactgagcca ctcccacctg        240

ctgctgcaca agaaggagaa tggcatctgg tccaccgaga tcctgaagaa cttcaagaac        300

aagaccttcc tgaagtgtga ggcccctaat tactccggca ggtttacatg ctcctggctg        360

gtgcagagaa acatggacct gaagtttaat atcaagagct cctcctccag ccccgatagc        420

agagccgtga cctgtggcat ggccagcctg agcgccgaga aggtgaccct ggatcagagg        480

gattacgaga agtactccgt gtcctgtcag gaggatgtga catgtcctac agccgaggag        540

acactgccta tcgagctggc cctggaggcc aggcagcaga ataagtacga gaactacagc        600

acaagctttt tcatcaggga catcatcaag cccgatcccc ccaagaacct gcagatgaag        660

cccctgaaga acagccaggt ggaggtgtcc tgggagtacc ctgatagctg gtccacccct        720

cactcctact tctccctgaa gttctttgtg agaatccagg ccgcggctga gaagatggcc        780

gagacagagg agggctgcaa tcagaagggc gccttcctgg tggagaagac atccaccgag        840

gtgcagtgta agggcggcaa cgtgtgcgtg caggcccagg acagatacta caattccagc        900

tgtagcaagt gggcctgtgt gccttgtaga gtgagatccg gcggcggcgg ctccggagga        960

ggaggaagcg gaggaggcgg ctccagagtg atccctgtgt ccggccctgc cagatgtctg       1020

tcccagagca gaaacctgct gaagaccaca gacgacatgg tgaagacagc cagagagaag       1080

ctgaagcact acagctgcac cgccgaggac atcgaccacg aggatatcac aagagaccag       1140

acatccaccc tgaagacatg tctgcctctg gagctgcaca agaatgagtc ctgcctggcc       1200

accagagaga cctccagcac caccaggggc agctgcctgc cccctcagaa gacctccctg       1260

atgatgacac tgtgcctggg cagcatctac gaggacctga agatgtacca gaccgagttc       1320

caggccatca atgccgccct gcagaaccac aaccaccagc agatcatcct ggataagggc       1380

atgctggtgg ccatcgacga gctgatgcag agcctgaacc acaatggcga gaccctgagg       1440

cagaagcctc ctgtgggcga ggccgatccc tacagagtga agatgaagct gtgtatcctg       1500

ctgcacgcct tttccacaag ggtggtgacc atcaacaggg tcatgggcta cctgtccagc       1560

gccggcggcg gcggcagcgg aggaggaggc tccgagccac gcggccccac aatcaagcca       1620

tgcccccctt gcaagtgtcc tgcaccaaat ctgctgggag gaccatccgt gttcatcttt       1680

ccacccaaga tcaaggacgt gctgatgatc agcctgtccc caatcgtgac ctgcgtggtc       1740

gtggacgtga gcgaggacga tcctgatgtg cagatctcct ggttcgtgaa caatgtggag       1800

gtgcacaccg cccagaccca gacacaccgg gaggactaca actccacact gagagtggtg       1860

tctgccctgc ccatccagca ccaggactgg atgagcggca aggagtttaa gtgcaaggtg       1920

aacaataagg atctgcccgc ccctatcgag cggacaatct ctaagcctaa gggcagcgtg       1980

agagccccac aggtgtatgt gctgcctcca cccgaggagg agatgaccaa gaagcaggtg       2040

acactgactt gtatggtgac cgacttcatg cctgaggata tctatgtgga gtggaccaac       2100

aatggcaaga cagagctgaa ctacaagaat acagagccag tgctggactc cgatggctct       2160

tacttcatgt acagcaagct gagggtggag aagaagaact gggtggagcg caattcttac       2220

agctgctccg tggtgcacga gggcctgcac aaccaccaca ccacaaagtc ttttagccgg       2280

acccctggca ag                                                           2292


<210>    79
<211>    1344
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu FAP HC mu IgG2a Fc knob


<400>    79
caggtgcagc tgcagcagtc cggagcagag ctggcaaggc ctggagcctc tgtgaacctg         60

agctgcaagg cctccggcta caccttcaca aacaatggca tcaattggct gaagcagagg        120

accggacagg gactggagtg gatcggcgag atctacccaa gatctaccaa cacactgtat        180

aatgagaagt tcaagggcaa ggccaccctg acagcagacc ggagctccaa caccgcctac        240

atggagctga gaagcctgac atccgaggat tctgccgtgt atttttgtgc acgcaccctg        300

acagcaccct tcgccttttg gggacagggc accctggtga cagtgagcgc cgcaaagacc        360

acagcaccaa gcgtgtatcc actggcaccc gtgtgcggcg ataccacagg ctctagcgtg        420

accctgggct gtctggtgaa gggctacttc cctgagccag tgaccctgac atggaacagc        480

ggctctctgt cctctggcgt gcacaccttt cctgccgtgc tgcagtccga tctgtataca        540

ctgagctcct ctgtgaccgt gacaagctcc acctggccca gccagtccat cacatgcaac        600

gtggcccacc ctgcctctag caccaaggtg gacaagaaga tcgagccacg gggccccaca        660

atcaagccat gtccaccttg caagtgtcca gcacctaatc tgctgggagg acctagcgtg        720

ttcatctttc cacccaagat caaggacgtg ctgatgatct ctctgagccc tatcgtgacc        780

tgcgtggtgg tggacgtgtc tgaggacgat ccagatgtgc agatcagctg gttcgtgaac        840

aatgtggagg tgcacaccgc ccagacccag acacaccggg aggactacaa ctccacactg        900

agagtggtgt ctgccctgcc catccagcac caggactgga tgtccggcaa ggagtttaag        960

tgcaaggtga acaataagga tctgccagcc cccatcgaga ggaccatctc taagcctaag       1020

ggcagcgtgc gcgcaccaca ggtgtatgtg ctgcctccac ccgaggagga gatgaccaag       1080

aagcaggtga cactgtggtg tatggtgacc gacttcatgc cagaggatat ctacgtggag       1140

tggaccaaca atggcaagac agagctgaac tataagaata cagagcccgt gctggacagc       1200

gatggctcct actttatgta tagcaagctg agggtggaga agaagaactg ggtggagcgc       1260

aattcctact cttgtagcgt ggtgcacgag ggcctgcaca accaccacac cacaaagtcc       1320

ttttctagaa cccccggcaa gtga                                              1344


<210>    80
<211>    639
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu FAP LC


<400>    80
cagatcgtgc tgacacagtc ccctgccatc atgtctgcca gcccaggcga gaaggtgacc         60

atgacatgct ctgccagctc cggcgtgaac ttcatgcact ggtaccagca gaagtctggc        120

acaagcccca agcggtggat cttcgacacc tccaagctgg cctctggcgt gcctgccaga        180

ttttccggct ctggcagcgg cacatcctat tctctgacca tctctagcat ggaggccgag        240

gacgccgcca cctactattg ccagcagtgg agcttcaatc cccctacatt tggcggcggc        300

accaagctgg agatcaagag ggcagatgca gcaccaacag tgtccatctt tccaccctcc        360

tctgagcagc tgaccagcgg aggagcatcc gtggtgtgct tcctgaacaa cttctacccc        420

aaggacatca acgtgaagtg gaagatcgat ggctctgaga ggcagaacgg cgtgctgaat        480

agctggacag accaggattc caaggactct acctatagca tgagctccac cctgacactg        540

accaaggatg agtacgagag gcacaatagc tatacatgcg aggccaccca caagacaagc        600

acctccccta tcgtgaagtc cttcaaccgc aatgagtgt                               639


<210>    81
<211>    1341
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu FAP HC mu IgG2a Fc knob DANG


<400>    81
caggtgcagc tgcagcagtc cggagcagag ctggcaaggc ctggagcctc tgtgaacctg         60

agctgcaagg cctccggcta caccttcaca aacaatggca tcaattggct gaagcagagg        120

accggacagg gactggagtg gatcggcgag atctacccaa gatctaccaa cacactgtat        180

aatgagaagt tcaagggcaa ggccaccctg acagcagacc ggagctccaa caccgcctac        240

atggagctga gaagcctgac atccgaggat tctgccgtgt atttttgtgc acgcaccctg        300

acagcaccct tcgccttttg gggacagggc accctggtga cagtgagcgc cgccaagacc        360

acagcaccaa gcgtgtatcc actggcaccc gtgtgcggcg ataccacagg ctctagcgtg        420

accctgggct gtctggtgaa gggctacttc cctgagccag tgaccctgac atggaacagc        480

ggctctctgt cctctggcgt gcacaccttt cctgccgtgc tgcagtccga tctgtataca        540

ctgagctcct ctgtgaccgt gacaagctcc acctggccca gccagtccat cacatgcaac        600

gtggcccacc ctgcctctag caccaaggtg gacaagaaga tcgagccacg gggccccaca        660

atcaagccat gtccaccttg caagtgtcca gcacctaatc tgctgggagg acctagcgtg        720

ttcatctttc cacccaagat caaggacgtg ctgatgatct ctctgagccc tatcgtgacc        780

tgcgtggtgg tggccgtgtc tgaggacgat ccagatgtgc agatcagctg gttcgtgaac        840

aatgtggagg tgcacaccgc ccagacccag acacaccggg aggactacgg ctccacactg        900

agagtggtgt ctgccctgcc catccagcac caggactgga tgtccggcaa ggagtttaag        960

tgcaaggtga acaataagga tctgccagcc cccatcgaga ggaccatctc taagcctaag       1020

ggcagcgtgc gcgcaccaca ggtgtatgtg ctgcctccac ccgaggagga gatgaccaag       1080

aagcaggtga cactgtggtg tatggtgacc gacttcatgc cagaggatat ctacgtggag       1140

tggaccaaca atggcaagac agagctgaac tataagaata cagagcccgt gctggacagc       1200

gatggctcct actttatgta tagcaagctg agggtggaga agaagaactg ggtggagcgc       1260

aattcctact cttgtagcgt ggtgcacgag ggcctgcaca accaccacac cacaaagtcc       1320

ttttctagaa cccccggcaa g                                                 1341


<210>    82
<211>    699
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc knob DANG


<400>    82
gagccaaggg gccccaccat caagccatgc cccccttgca agtgtcctgc accaaacctg         60

ctgggaggac caagcgtgtt catctttcca cccaagatca aggacgtgct gatgatcagc        120

ctgtccccca tcgtgacatg cgtggtggtg gccgtgtccg aggacgatcc tgatgtgcag        180

atctcttggt tcgtgaacaa tgtggaggtg cacaccgccc agacccagac acaccgggag        240

gactacggct ctacactgag agtggtgagc gccctgccca tccagcacca ggactggatg        300

tccggcaagg agtttaagtg caaggtgaac aataaggatc tgcccgcccc tatcgagcgg        360

accatcagca agcctaaggg ctccgtgaga gccccacagg tgtatgtgct gcctccaccc        420

gaggaggaga tgaccaagaa gcaggtgaca ctgtggtgta tggtgaccga cttcatgcct        480

gaggatatct acgtggagtg gaccaacaat ggcaagacag agctgaacta taagaataca        540

gagccagtgc tggactccga tggctcttac tttatgtatt ctaagctgag ggtggagaag        600

aagaactggg tggagcgcaa ttcttacagc tgctccgtgg tgcacgaggg cctgcacaat        660

caccacacca caaagtcttt cagcagaacc cctggcaag                               699


<210>    83
<211>    699
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc hole DANG


<400>    83
gagccaaggg gccccaccat caagccatgc cccccttgca agtgtcctgc accaaacctg         60

ctgggaggac caagcgtgtt catctttcca cccaagatca aggacgtgct gatgatcagc        120

ctgtccccca tcgtgacatg cgtggtggtg gccgtgtccg aggacgatcc tgatgtgcag        180

atctcttggt tcgtgaacaa tgtggaggtg cacaccgccc agacccagac acaccgggag        240

gactatggct ctacactgag agtggtgagc gccctgccca tccagcacca ggactggatg        300

agcggcaagg agtttaagtg caaggtgaac aataaggatc tgcccgcccc tatcgagcgg        360

accatcagca agcctaaggg ctccgtgaga gccccacagg tgtacgtgct gcctccaccc        420

gaggaggaga tgaccaagaa gcaggtgaca ctgagctgtg ccgtgaccga cttcatgcct        480

gaggatatct acgtggagtg gaccaacaat ggcaagacag agctgaacta taagaataca        540

gagccagtgc tggactccga tggctcttac tttatggtgt ccaagctgag ggtggagaag        600

aagaactggg tggagcgcaa ttcttatagc tgctccgtgg tgcacgaggg cctgcacaat        660

caccacacca caaagtcttt cagcagaacc cctggcaag                               699


<210>    84
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 (18B12) HC


<400>    84
caggtgcagc tgcagcagcc aggagcagag ctggtgaggc caggcacctc tgtgaagctg         60

agctgcaagg cctccggcta caccttcaca tcttattgga tgcactggat caagcagagg        120

ccaggacagg gactggagtg gatcggcgtg atcgacccct ccgataacta caccaagtac        180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca ccagctcctc tacagcctac        240

atgcagctga gctccctgac atccgaggat tctgccgtgt atttctgtgc ccgggagggc        300

tactatggct ctagcccatg gtttgcctac tggggccagg gcaccctggt gacagtgtcc        360

tctgccaaga ccacagcccc cagcgtgtat cctctggccc cagtgtgcgg cgataccaca        420

ggcagctccg tgaccctggg ctgtctggtg aagggctact tccctgagcc agtgaccctg        480

acatggaact ctggcagcct gtctagcgga gtgcacacct ttccagccgt gctgcagtcc        540

gatctgtata cactgtcctc tagcgtgacc gtgacatcct ctacctggcc ctcccagtct        600

atcacatgca acgtggccca ccctgccagc tccaccaagg tggacaagaa gatcgagccc        660

cggggcccta caatcaagcc atgtccacct tgcaagtgtc cagcacctaa tctgctggga        720

ggacctagcg tgttcatctt tccacccaag atcaaggacg tgctgatgat cagcctgtcc        780

cctatcgtga cctgcgtggt ggtggacgtg agcgaggacg atccagatgt gcagatctcc        840

tggttcgtga acaatgtgga ggtgcacacc gcccagaccc agacacaccg ggaggactac        900

aactccacac tgagagtggt gtctgccctg cctatccagc accaggactg gatgtccggc        960

aaggagttta agtgcaaggt gaacaataag gatctgccag cccccatcga gcggaccatc       1020

tctaagccta agggcagcgt gagagcccca caggtgtatg tgctgcctcc acccgaggag       1080

gagatgacca agaagcaggt gacactgacc tgtatggtga ccgacttcat gcctgaggat       1140

atctacgtgg agtggaccaa caatggcaag acagagctga actataagaa tacagagcca       1200

gtgctggaca gcgatggctc ctactttatg tatagcaagc tgagggtgga gaagaagaac       1260

tgggtggagc gcaattctta cagctgttcc gtggtgcacg agggcctgca caatcaccac       1320

accacaaagt ctttcagcag aacccccggc aag                                    1353


<210>    85
<211>    219
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC


<400>    85
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
    210                 215                


<210>    86
<211>    217
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc DANG


<400>    86
Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
  1               5                  10                  15 

Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
             20                  25                  30 

Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
         35                  40                  45 

Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
     50                  55                  60 

Asp Tyr Gly Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
 65                  70                  75                  80 

Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
                 85                  90                  95 

Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser
            100                 105                 110 

Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met
        115                 120                 125 

Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro
    130                 135                 140 

Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn
145                 150                 155                 160 

Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met
                165                 170                 175 

Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser
            180                 185                 190 

Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr
        195                 200                 205 

Lys Ser Phe Ser Arg Thr Pro Gly Lys
    210                 215        


<210>    87
<211>    209
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc DANG


<400>    87
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
  1               5                  10                  15 

Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp
             20                  25                  30 

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
         35                  40                  45 

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val
     50                  55                  60 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
 65                  70                  75                  80 

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                 85                  90                  95 

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            100                 105                 110 

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        115                 120                 125 

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    130                 135                 140 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
145                 150                 155                 160 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                165                 170                 175 

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            180                 185                 190 

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        195                 200                 205 

Lys
   


<210>    88
<211>    247
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 scFv


<400>    88
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val
    130                 135                 140 

Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val
145                 150                 155                 160 

Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe
                165                 170                 175 

Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser
            180                 185                 190 

Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly
        195                 200                 205 

Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala
    210                 215                 220 

Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly
225                 230                 235                 240 

Gly Thr Lys Leu Glu Ile Lys
                245        


<210>    89
<211>    247
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 scFv


<400>    89
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val
    130                 135                 140 

Met Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val
145                 150                 155                 160 

Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr Ile His Trp Tyr
                165                 170                 175 

Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser
            180                 185                 190 

Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly
        195                 200                 205 

Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala Glu Asp Ala Ala
    210                 215                 220 

Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Lys Pro Pro Thr Phe Gly Gly
225                 230                 235                 240 

Gly Thr Lys Leu Glu Ile Lys
                245        


<210>    90
<211>    218
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC


<400>    90
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile
    210                 215            


<210>    91
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    linker 1


<400>    91
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
  1               5                  10


<210>    92
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    linker 2


<400>    92
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
  1               5                  10                  15


<210>    93
<211>    20
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    linker 3


<400>    93
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
  1               5                  10                  15 

Gly Gly Gly Ser
             20


<210>    94
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Hinge


<400>    94
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
  1               5                  10                  15 

Pro Glu Leu Leu Gly Gly Pro
             20            


<210>    95
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Hinge-core 1


<400>    95
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
  1               5                  10                


<210>    96
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Hinge-core 2


<400>    96
Asp Lys Thr His Thr Cys Pro Pro Cys
  1               5                


<210>    97
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Hinge-core 3


<400>    97
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
  1               5                  10    


<210>    98
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Hinge-core 4


<400>    98
Cys Pro Pro Cys Pro
  1               5


<210>    99
<211>    4
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Hinge-core 5


<400>    99
Cys Pro Pro Cys
  1            


<210>    100
<211>    28
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Hinge Linker


<400>    100
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys
  1               5                  10                  15 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
             20                  25            


<210>    101
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Hinge


<400>    101
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
  1               5                  10                  15 




<210>    102
<211>    26
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Hinge Linker


<400>    102
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Arg Gly Pro Thr
  1               5                  10                  15 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
             20                  25    


<210>    103
<211>    227
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc knob


<400>    103
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
  1               5                  10                  15 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
             20                  25                  30 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
         35                  40                  45 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
     50                  55                  60 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
 65                  70                  75                  80 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                 85                  90                  95 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            100                 105                 110 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        115                 120                 125 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    130                 135                 140 

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
145                 150                 155                 160 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                165                 170                 175 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            180                 185                 190 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        195                 200                 205 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    210                 215                 220 

Pro Gly Lys
225        


<210>    104
<211>    227
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc hole


<400>    104
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
  1               5                  10                  15 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
             20                  25                  30 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
         35                  40                  45 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
     50                  55                  60 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
 65                  70                  75                  80 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                 85                  90                  95 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            100                 105                 110 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        115                 120                 125 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    130                 135                 140 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
145                 150                 155                 160 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                165                 170                 175 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
            180                 185                 190 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        195                 200                 205 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    210                 215                 220 

Pro Gly Lys
225        


<210>    105
<211>    233
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc knob


<400>    105
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
  1               5                  10                  15 

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
             20                  25                  30 

Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
         35                  40                  45 

Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
     50                  55                  60 

Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
 65                  70                  75                  80 

Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
                 85                  90                  95 

Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
            100                 105                 110 

Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser
        115                 120                 125 

Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met
    130                 135                 140 

Thr Lys Lys Gln Val Thr Leu Trp Cys Met Val Thr Asp Phe Met Pro
145                 150                 155                 160 

Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn
                165                 170                 175 

Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met
            180                 185                 190 

Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser
        195                 200                 205 

Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr
    210                 215                 220 

Lys Ser Phe Ser Arg Thr Pro Gly Lys
225                 230            


<210>    106
<211>    233
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc hole


<400>    106
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
  1               5                  10                  15 

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
             20                  25                  30 

Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
         35                  40                  45 

Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
     50                  55                  60 

Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
 65                  70                  75                  80 

Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
                 85                  90                  95 

Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
            100                 105                 110 

Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser
        115                 120                 125 

Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met
    130                 135                 140 

Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp Phe Met Pro
145                 150                 155                 160 

Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn
                165                 170                 175 

Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met
            180                 185                 190 

Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser
        195                 200                 205 

Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr
    210                 215                 220 

Lys Ser Phe Ser Arg Thr Pro Gly Lys
225                 230            


<210>    107
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HCDR1


<400>    107
Ser Tyr Asn Met His
  1               5


<210>    108
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HCDR2


<400>    108
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    109
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HCDR3


<400>    109
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val
  1               5                  10        


<210>    110
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LCDR1


<400>    110
Arg Ala Ser Ser Ser Val Ser Tyr Ile His
  1               5                  10


<210>    111
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LCDR2


<400>    111
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    112
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LCDR3


<400>    112
Gln Gln Trp Thr Ser Asn Pro Pro Thr
  1               5                


<210>    113
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HCVR


<400>    113
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala
        115                 120    


<210>    114
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 LCVR


<400>    114
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105    


<210>    115
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HCDR1


<400>    115
Ser Tyr Trp Met His
  1               5


<210>    116
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HCDR2


<400>    116
Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    117
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HCDR3


<400>    117
Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr
  1               5                  10        


<210>    118
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LCDR1


<400>    118
Arg Ala Arg Ser Ser Val Ser Tyr Ile His
  1               5                  10


<210>    119
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LCDR2


<400>    119
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    120
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LCDR3


<400>    120
Gln Gln Trp Ser Ser Lys Pro Pro Thr
  1               5                


<210>    121
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HCVR


<400>    121
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    122
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 LCVR


<400>    122
Gln Ile Val Met Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Arg Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Lys Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105    


<210>    123
<211>    518
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12


<400>    123
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser
        515            


<210>    124
<211>    306
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 p40


<400>    124
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser
305    


<210>    125
<211>    197
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 p35


<400>    125
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu
  1               5                  10                  15 

His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys
             20                  25                  30 

Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp
         35                  40                  45 

His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu
     50                  55                  60 

Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr
 65                  70                  75                  80 

Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe
                 85                  90                  95 

Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr
            100                 105                 110 

Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys
        115                 120                 125 

Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu
    130                 135                 140 

Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser
145                 150                 155                 160 

Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu
                165                 170                 175 

Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser
            180                 185                 190 

Tyr Leu Asn Ala Ser
        195        


<210>    126
<211>    518
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut1


<400>    126
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Lys Arg Glu Ala Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser
        515            


<210>    127
<211>    306
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut1 p40


<400>    127
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Lys Arg Glu Ala Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser
305    


<210>    128
<211>    518
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2


<400>    128
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser
        515            


<210>    129
<211>    306
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2 p40


<400>    129
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser
305    


<210>    130
<211>    521
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12


<400>    130
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys
                245                 250                 255 

Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala
        515                 520    


<210>    131
<211>    313
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 p40


<400>    131
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys
                245                 250                 255 

Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser
305                 310            


<210>    132
<211>    193
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 p35


<400>    132
Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg
  1               5                  10                  15 

Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys
             20                  25                  30 

Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile
         35                  40                  45 

Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu
     50                  55                  60 

His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr
 65                  70                  75                  80 

Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu
                 85                  90                  95 

Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe
            100                 105                 110 

Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile
        115                 120                 125 

Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu
    130                 135                 140 

Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala
145                 150                 155                 160 

Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe
                165                 170                 175 

Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser
            180                 185                 190 

Ala
   


<210>    133
<211>    521
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut1


<400>    133
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Ala Lys
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala
        515                 520    


<210>    134
<211>    313
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut1 p40


<400>    134
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Ala Lys
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser
305                 310            


<210>    135
<211>    521
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2


<400>    135
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala Ala Ala
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala
        515                 520    


<210>    136
<211>    313
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2 p40


<400>    136
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala Ala Ala
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser
305                 310            


<210>    137
<211>    328
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IL-12 p40 wt_AAD56386


<400>    137
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu
  1               5                  10                  15 

Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val
             20                  25                  30 

Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu
         35                  40                  45 

Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln
     50                  55                  60 

Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys
 65                  70                  75                  80 

Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val
                 85                  90                  95 

Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp
            100                 105                 110 

Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe
        115                 120                 125 

Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp
    130                 135                 140 

Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg
145                 150                 155                 160 

Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser
                165                 170                 175 

Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu
            180                 185                 190 

Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile
        195                 200                 205 

Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr
    210                 215                 220 

Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn
225                 230                 235                 240 

Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp
                245                 250                 255 

Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr
            260                 265                 270 

Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg
        275                 280                 285 

Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala
    290                 295                 300 

Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser
305                 310                 315                 320 

Glu Trp Ala Ser Val Pro Cys Ser
                325            


<210>    138
<211>    219
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IL-12 p35 wt_AAK84425


<400>    138
Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu
  1               5                  10                  15 

Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro
             20                  25                  30 

Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val
         35                  40                  45 

Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys
     50                  55                  60 

Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser
 65                  70                  75                  80 

Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys
                 85                  90                  95 

Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala
            100                 105                 110 

Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr
        115                 120                 125 

Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys
    130                 135                 140 

Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu
145                 150                 155                 160 

Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr
                165                 170                 175 

Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys
            180                 185                 190 

Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr
        195                 200                 205 

Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser
    210                 215                


<210>    139
<211>    335
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IL-12 p40 wt_AAA39296


<400>    139
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu
  1               5                  10                  15 

Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val
             20                  25                  30 

Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu
         35                  40                  45 

Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln
     50                  55                  60 

Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys
 65                  70                  75                  80 

Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr
                 85                  90                  95 

Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp
            100                 105                 110 

Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys
        115                 120                 125 

Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln
    130                 135                 140 

Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro
145                 150                 155                 160 

Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys
                165                 170                 175 

Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln
            180                 185                 190 

Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu
        195                 200                 205 

Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser
    210                 215                 220 

Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln
225                 230                 235                 240 

Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro
                245                 250                 255 

Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val
            260                 265                 270 

Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys
        275                 280                 285 

Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln
    290                 295                 300 

Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn
305                 310                 315                 320 

Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser
                325                 330                 335


<210>    140
<211>    215
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IL-12 p35 wt_AAK39292


<400>    140
Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Ala Leu Leu
  1               5                  10                  15 

Asn His Leu Ser Leu Ala Arg Val Ile Pro Val Ser Gly Pro Ala Arg
             20                  25                  30 

Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val
         35                  40                  45 

Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp
     50                  55                  60 

Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr
 65                  70                  75                  80 

Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg
                 85                  90                  95 

Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr
            100                 105                 110 

Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys
        115                 120                 125 

Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His
    130                 135                 140 

Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp
145                 150                 155                 160 

Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys
                165                 170                 175 

Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys
            180                 185                 190 

Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val
        195                 200                 205 

Met Gly Tyr Leu Ser Ser Ala
    210                 215


<210>    141
<211>    252
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IL-12 p40_X1


<400>    141
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys
                245                 250        


<210>    142
<211>    42
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IL-12 p40_X2


<400>    142
Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys
  1               5                  10                  15 

Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser
             20                  25                  30 

Trp Ser Glu Trp Ala Ser Val Pro Cys Ser
         35                  40        


<210>    143
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocrelizumab HCDR1


<400>    143
Gly Tyr Thr Phe Thr Ser Tyr Asn Met His
  1               5                  10


<210>    144
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocrelizumab HCDR2


<400>    144
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    145
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocrelizumab HCDR3


<400>    145
Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
  1               5                  10            


<210>    146
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocrelizumab LCDR1


<400>    146
Arg Ala Ser Ser Ser Val Ser Tyr Met His
  1               5                  10


<210>    147
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocrelizumab LCDR2


<400>    147
Ala Pro Ser Asn Leu Ala Ser
  1               5        


<210>    148
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocrelizumab LCDR3


<400>    148
Gln Gln Trp Ser Phe Asn Pro Pro Thr
  1               5                


<210>    149
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG-7159 HCDR1


<400>    149
Tyr Ser Trp Ile Asn
  1               5


<210>    150
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG-7159 HCDR2


<400>    150
Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    151
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG-7159 HCDR3


<400>    151
Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr
  1               5                  10


<210>    152
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG-7159 LCDR1


<400>    152
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr
  1               5                  10                  15 




<210>    153
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG-7159 LCDR2


<400>    153
Gln Met Ser Asn Leu Val Ser
  1               5        


<210>    154
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG-7159 LCDR3


<400>    154
Ala Gln Asn Leu Glu Leu Pro Tyr Thr
  1               5                


<210>    155
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ofatumumab HCDR1


<400>    155
Asn Asp Tyr Ala Met His
  1               5    


<210>    156
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ofatumumab HCDR2


<400>    156
Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    157
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ofatumumab HCDR3


<400>    157
Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val
  1               5                  10            


<210>    158
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ofatumumab LCDR1


<400>    158
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala
  1               5                  10    


<210>    159
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ofatumumab LCDR2


<400>    159
Asp Ala Ser Asn Arg Ala Thr
  1               5        


<210>    160
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ofatumumab LCDR3


<400>    160
Gln Gln Arg Ser Asn Trp Pro Ile Thr
  1               5                


<210>    161
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2B8 HCDR1


<400>    161
Ser Tyr Asn Met His
  1               5


<210>    162
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2B8 HCDR2


<400>    162
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    163
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2B8 HCDR3


<400>    163
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val
  1               5                  10        


<210>    164
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2B8 LCDR1


<400>    164
Arg Ala Ser Ser Ser Val Ser Tyr Ile His
  1               5                  10


<210>    165
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2B8 LCDR2


<400>    165
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    166
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2B8 LCDR3


<400>    166
Gln Gln Trp Thr Ser Asn Pro Pro Thr
  1               5                


<210>    167
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Tositumomab HCDR1


<400>    167
Ser Tyr Asn Met His
  1               5


<210>    168
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Tositumomab HCDR2


<400>    168
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    169
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Tositumomab HCDR3


<400>    169
Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
  1               5                  10            


<210>    170
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Tositumomab LCDR1


<400>    170
Arg Ala Ser Ser Ser Val Ser Tyr Met His
  1               5                  10


<210>    171
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Tositumomab LCDR2


<400>    171
Ala Pro Ser Asn Leu Ala Ser
  1               5        


<210>    172
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Tositumomab LCDR3


<400>    172
Gln Gln Trp Ser Phe Asn Pro Pro Thr
  1               5                


<210>    173
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ublituximab HCDR1


<400>    173
Gly Tyr Thr Phe Thr Ser Tyr Asn
  1               5            


<210>    174
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ublituximab HCDR2


<400>    174
Ile Tyr Pro Gly Asn Gly Asp Thr
  1               5            


<210>    175
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ublituximab HCDR3


<400>    175
Ala Arg Tyr Asp Tyr Asn Tyr Ala Met Asp Tyr
  1               5                  10    


<210>    176
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ublituximab LCDR1


<400>    176
Ser Ser Val Ser Tyr
  1               5


<210>    177
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ublituximab LCDR2


<400>    177
Ala Thr Ser
  1        


<210>    178
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ublituximab LCDR3


<400>    178
Gln Gln Trp Thr Phe Asn Pro Pro Thr
  1               5                


<210>    179
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epcortitamab, 7D8 HCDR1


<400>    179
Gly Phe Thr Phe His Asp Tyr Ala
  1               5            


<210>    180
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epcortitamab, 7D8 HCDR2


<400>    180
Ile Ser Trp Asn Ser Gly Thr Ile
  1               5            


<210>    181
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epcortitamab, 7D8 HCDR3


<400>    181
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val
  1               5                  10                  15


<210>    182
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epcortitamab, 7D8 LCDR1


<400>    182
Gln Ser Val Ser Ser Tyr
  1               5    


<210>    183
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epcortitamab, 7D8 LCDR2


<400>    183
Asp Ala Ser
  1        


<210>    184
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epcortitamab, 7D8 LCDR3


<400>    184
Gln Gln Arg Ser Asn Trp Pro Ile Thr
  1               5                


<210>    185
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Divozilimab HCDR1


<400>    185
Ser Tyr Asn Met His
  1               5


<210>    186
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Divozilimab HCDR2


<400>    186
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    187
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Divozilimab HCDR3


<400>    187
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val
  1               5                  10        


<210>    188
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Divozilimab LCDR1


<400>    188
Arg Ala Ser Ser Ser Val Ser Tyr Ile His
  1               5                  10


<210>    189
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Divozilimab LCDR2


<400>    189
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    190
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Divozilimab LCDR3


<400>    190
Gln Gln Trp Thr Ser Asn Pro Pro Thr
  1               5                


<210>    191
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Odronextabmab HCDR1


<400>    191
Gly Phe Thr Phe Asn Asp Tyr Ala
  1               5            


<210>    192
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Odronextabmab HCDR2


<400>    192
Ile Ser Trp Asn Ser Asp Ser Ile
  1               5            


<210>    193
<211>    20
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Odronextabmab HCDR3


<400>    193
Ala Lys Asp Asn His Tyr Gly Ser Gly Ser Tyr Tyr Tyr Tyr Gln Tyr
  1               5                  10                  15 

Gly Met Asp Val
             20


<210>    194
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Odronextabmab LCDR1


<400>    194
Gln Ser Val Ser Ser Asn
  1               5    


<210>    195
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Odronextabmab LCDR2


<400>    195
Gly Ala Ser
  1        


<210>    196
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Odronextabmab LCDR3


<400>    196
Gln His Tyr Ile Asn Trp Pro Leu Thr
  1               5                


<210>    197
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Veltuzumab HCDR1


<400>    197
Ser Tyr Asn Met His
  1               5


<210>    198
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Veltuzumab HCDR2


<400>    198
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    199
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Veltuzumab HCDR3-1


<400>    199
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Val
  1               5                  10        


<210>    200
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Veltuzumab HCDR3-2


<400>    200
Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
  1               5                  10            


<210>    201
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Veltuzumab LCDR1


<400>    201
Arg Ala Ser Ser Ser Val Ser Tyr Ile His
  1               5                  10


<210>    202
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Veltuzumab LCDR2


<400>    202
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    203
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Veltuzumab LCDR3


<400>    203
Gln Gln Trp Thr Ser Asn Pro Pro Thr
  1               5                


<210>    204
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MB-CART2019.1 HCDR1


<400>    204
Ser Tyr Asn Met His
  1               5


<210>    205
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MB-CART2019.1 HCDR2


<400>    205
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    206
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MB-CART2019.1 HCDR3


<400>    206
Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val
  1               5                  10            


<210>    207
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MB-CART2019.1 LCDR1


<400>    207
Arg Ala Ser Ser Ser Val Asn Tyr Met Asp
  1               5                  10


<210>    208
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MB-CART2019.1 LCDR2


<400>    208
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    209
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    MB-CART2019.1 LCDR3


<400>    209
Gln Gln Trp Ser Phe Asn Pro Pro Thr
  1               5                


<210>    210
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocaratuzumab HCDR1


<400>    210
Gly Arg Thr Phe Thr Ser Tyr Asn Met His
  1               5                  10


<210>    211
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocaratuzumab HCDR2


<400>    211
Ala Ile Tyr Pro Leu Thr Gly Asp Thr Ser Tyr Asn Gln Lys Ser Lys
  1               5                  10                  15 




<210>    212
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocaratuzumab HCDR3


<400>    212
Ser Thr Tyr Val Gly Gly Asp Trp Gln Phe Asp Val
  1               5                  10        


<210>    213
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocaratuzumab LCDR1


<400>    213
Arg Ala Ser Ser Ser Val Pro Tyr Ile His
  1               5                  10


<210>    214
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocaratuzumab LCDR2


<400>    214
Ala Thr Ser Ala Leu Ala Ser
  1               5        


<210>    215
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Ocaratuzumab LCDR3


<400>    215
Gln Gln Trp Leu Ser Asn Pro Pro Thr
  1               5                


<210>    216
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    ADI-001 HCDR1


<400>    216
Gly Phe Thr Phe Tyr Asp Tyr Ala
  1               5            


<210>    217
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    ADI-001 HCDR2


<400>    217
Ile Ser Trp Asn Ser Gly Tyr Ile
  1               5            


<210>    218
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    ADI-001 HCDR3


<400>    218
Ala Lys Asp Asn Ser Tyr Gly Lys Phe Tyr Tyr Gly Leu Asp Val
  1               5                  10                  15


<210>    219
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    ADI-001 LCDR1


<400>    219
Gln Ser Val Ser Ser Asn
  1               5    


<210>    220
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    ADI-001 LCDR2


<400>    220
Gly Ala Ser
  1        


<210>    221
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    ADI-001 LCDR3


<400>    221
Gln Gln Tyr Asn Asn Trp Pro Ile Thr
  1               5                


<210>    222
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Pamotamab HCDR1


<400>    222
Tyr Thr Phe Thr Ser Tyr Asn
  1               5        


<210>    223
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Pamotamab HCDR2


<400>    223
Tyr Pro Gly Asn Gly Asp
  1               5    


<210>    224
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Pamotamab HCDR3


<400>    224
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val
  1               5                  10        


<210>    225
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Pamotamab LCDR1


<400>    225
Ser Ser Ser Val Ser Tyr
  1               5    


<210>    226
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Pamotamab LCDR2


<400>    226
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    227
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Pamotamab LCDR3


<400>    227
Trp Thr Ser Asn Pro Pro Thr
  1               5        


<210>    228
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    DNL-1 HCDR1


<400>    228
Ser Tyr Asn Met His
  1               5


<210>    229
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    DNL-1 HCDR2


<400>    229
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    230
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    DNL-1 HCDR3


<400>    230
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Val
  1               5                  10        


<210>    231
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    DNL-1 LCDR1


<400>    231
Arg Ala Ser Ser Ser Val Ser Tyr Ile His
  1               5                  10


<210>    232
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    DNL-1 LCDR2


<400>    232
Ala Thr Ser Asn Leu Ala Ser
  1               5        


<210>    233
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    DNL-1 LCDR3


<400>    233
Gln Gln Trp Thr Ser Asn Pro Pro Thr
  1               5                


<210>    234
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mAb-1.5.3 HCDR1


<400>    234
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly
  1               5                  10


<210>    235
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mAb-1.5.3 HCDR2


<400>    235
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln
  1               5                  10                  15 

Gly
   


<210>    236
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mAb-1.5.3 HCDR3


<400>    236
His Pro Ser Tyr Gly Ser Gly Ser Pro Asn Phe Asp Tyr
  1               5                  10            


<210>    237
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mAb-1.5.3 LCDR1


<400>    237
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Ser
  1               5                  10                  15 




<210>    238
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mAb-1.5.3 LCDR2


<400>    238
Lys Ile Ser Asn Arg Phe Ser
  1               5        


<210>    239
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mAb-1.5.3 LCDR3


<400>    239
Val Gln Ala Thr Gln Phe Pro Leu Thr
  1               5                


<210>    240
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Ocrelizumab


<400>    240
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    241
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Ocrelizumab


<400>    241
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr
         35                  40                  45 

Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
 65                  70                  75                  80 

Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105        


<210>    242
<211>    119
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of RG-7159


<400>    242
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser
             20                  25                  30 

Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe
     50                  55                  60 

Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly
            100                 105                 110 

Thr Leu Val Thr Val Ser Ser
        115                


<210>    243
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of RG-7159


<400>    243
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
             20                  25                  30 

Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
                 85                  90                  95 

Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105                 110 




<210>    244
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Ofatumumab


<400>    244
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp
            100                 105                 110 

Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120        


<210>    245
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Ofatumumab


<400>    245
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
            100                 105        


<210>    246
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of 2B8


<400>    246
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala
        115                 120    


<210>    247
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of 2B8


<400>    247
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105    


<210>    248
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Tositumomab


<400>    248
Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110 

Gly Thr Gly Thr Thr Val Thr Val Ser Gly
        115                 120        


<210>    249
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Tositumomab


<400>    249
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105    


<210>    250
<211>    118
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Ublituximab


<400>    250
Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Gly Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Gly Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Tyr Asp Tyr Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110 

Ser Val Thr Val Ser Ser
        115            


<210>    251
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Ublituximab


<400>    251
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Phe Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Phe Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys
            100                 105    


<210>    252
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Epcortitamab


<400>    252
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Asp Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp
            100                 105                 110 

Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120        


<210>    253
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Epcortitamab


<400>    253
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
            100                 105        


<210>    254
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Divozilimab


<400>    254
Glu Val Gln Leu Val Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    255
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Divozilimab


<400>    255
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Arg Val Thr Leu Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Arg Val Glu Pro Glu
 65                  70                  75                  80 

Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105    


<210>    256
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Odronextabmab


<400>    256
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Val Ile Ser Trp Asn Ser Asp Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Asn His Tyr Gly Ser Gly Ser Tyr Tyr Tyr Tyr Gln Tyr
            100                 105                 110 

Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125 




<210>    257
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Odronextabmab


<400>    257
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Ile Asn Trp Pro Leu
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    258
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Veltuzumab


<400>    258
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Val Trp Gly
            100                 105                 110 

Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120    


<210>    259
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Veltuzumab


<400>    259
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
 65                  70                  75                  80 

Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105        


<210>    260
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of MB-CART2019.1


<400>    260
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp
            100                 105                 110 

Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120        


<210>    261
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of MB-CART2019.1


<400>    261
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met
             20                  25                  30 

Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
 65                  70                  75                  80 

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105    


<210>    262
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Ocaratuzumab


<400>    262
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
  1               5                  10                  15 

Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Arg Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
         35                  40                  45 

Gly Ala Ile Tyr Pro Leu Thr Gly Asp Thr Ser Tyr Asn Gln Lys Ser
     50                  55                  60 

Lys Leu Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
 65                  70                  75                  80 

Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Val Gly Gly Asp Trp Gln Phe Asp Val Trp Gly
            100                 105                 110 

Lys Gly Thr Thr Val Thr Val Ser Ser
        115                 120    


<210>    263
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Ocaratuzumab


<400>    263
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Pro Tyr Ile
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
         35                  40                  45 

Ala Thr Ser Ala Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu
 65                  70                  75                  80 

Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Leu Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105    


<210>    264
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of ADI-001


<400>    264
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Tyr Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Asn Ser Tyr Gly Lys Phe Tyr Tyr Gly Leu Asp Val Trp
            100                 105                 110 

Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120        


<210>    265
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of ADI-001


<400>    265
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Thr Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
             20                  25                  30 

Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Glu Phe Ile Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Ile
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
            100                 105        


<210>    266
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of Pamotamab


<400>    266
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    267
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of Pamotamab


<400>    267
Gln Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Leu Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
 65                  70                  75                  80 

Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105    


<210>    268
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of DNL-1


<400>    268
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Val Trp Gly
            100                 105                 110 

Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120    


<210>    269
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of DNL-1


<400>    269
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
             20                  25                  30 

His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr
         35                  40                  45 

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
 65                  70                  75                  80 

Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105    


<210>    270
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH of mAb-1.5.3


<400>    270
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
  1               5                  10                  15 

Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
             20                  25                  30 

Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
         35                  40                  45 

Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
     50                  55                  60 

Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr
 65                  70                  75                  80 

Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                 85                  90                  95 

Ala Arg His Pro Ser Tyr Gly Ser Gly Ser Pro Asn Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    271
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL of mAb-1.5.3


<400>    271
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly
  1               5                  10                  15 

Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
             20                  25                  30 

Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro
         35                  40                  45 

Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Ala
                 85                  90                  95 

Thr Gln Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105                 110 




<210>    272
<211>    1016
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12-hu IgG1 Fc hole-anti-hu CD20 scFv


<400>    272
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        755                 760                 765 

Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly
    770                 775                 780 

Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser
785                 790                 795                 800 

Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp
                805                 810                 815 

Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys
            820                 825                 830 

Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala
        835                 840                 845 

Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr
    850                 855                 860 

Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp
865                 870                 875                 880 

Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly
                885                 890                 895 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile
            900                 905                 910 

Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys
        915                 920                 925 

Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp
    930                 935                 940 

Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr
945                 950                 955                 960 

Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser
                965                 970                 975 

Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala
            980                 985                 990 

Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly
        995                1000                1005 

Gly Gly Thr Lys Leu Glu Ile Lys
   1010                1015    


<210>    273
<211>    1016
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2-hu IgG1 Fc hole-anti-hu CD20 scFv


<400>    273
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        755                 760                 765 

Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly
    770                 775                 780 

Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser
785                 790                 795                 800 

Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp
                805                 810                 815 

Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys
            820                 825                 830 

Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala
        835                 840                 845 

Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr
    850                 855                 860 

Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp
865                 870                 875                 880 

Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly
                885                 890                 895 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile
            900                 905                 910 

Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys
        915                 920                 925 

Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp
    930                 935                 940 

Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr
945                 950                 955                 960 

Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser
                965                 970                 975 

Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala
            980                 985                 990 

Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly
        995                1000                1005 

Gly Gly Thr Lys Leu Glu Ile Lys
   1010                1015    


<210>    274
<211>    983
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc-hu scIL-12


<400>    274
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    450                 455                 460 

Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp
465                 470                 475                 480 

Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro
                485                 490                 495 

Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu
            500                 505                 510 

Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala
        515                 520                 525 

Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu
    530                 535                 540 

Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu
545                 550                 555                 560 

Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala
                565                 570                 575 

Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser
            580                 585                 590 

Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro
        595                 600                 605 

Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg
    610                 615                 620 

Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser
625                 630                 635                 640 

Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp
                645                 650                 655 

Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile
            660                 665                 670 

Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro
        675                 680                 685 

Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr
    690                 695                 700 

Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val
705                 710                 715                 720 

Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys
                725                 730                 735 

Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg
            740                 745                 750 

Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val
        755                 760                 765 

Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    770                 775                 780 

Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro
785                 790                 795                 800 

Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu
                805                 810                 815 

Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu
            820                 825                 830 

Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala
        835                 840                 845 

Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg
    850                 855                 860 

Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr
865                 870                 875                 880 

Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys
                885                 890                 895 

Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp
            900                 905                 910 

Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp
        915                 920                 925 

Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys
    930                 935                 940 

Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys
945                 950                 955                 960 

Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val
                965                 970                 975 

Met Ser Tyr Leu Asn Ala Ser
            980            


<210>    275
<211>    983
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-hu CD20 HC hu IgG1 Fc-hu scIL-12 mut2


<400>    275
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110 

Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    450                 455                 460 

Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp
465                 470                 475                 480 

Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro
                485                 490                 495 

Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu
            500                 505                 510 

Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala
        515                 520                 525 

Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu
    530                 535                 540 

Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu
545                 550                 555                 560 

Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala
                565                 570                 575 

Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser
            580                 585                 590 

Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro
        595                 600                 605 

Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg
    610                 615                 620 

Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser
625                 630                 635                 640 

Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp
                645                 650                 655 

Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile
            660                 665                 670 

Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro
        675                 680                 685 

Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr
    690                 695                 700 

Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val
705                 710                 715                 720 

Gln Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp Lys
                725                 730                 735 

Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg
            740                 745                 750 

Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val
        755                 760                 765 

Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    770                 775                 780 

Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro
785                 790                 795                 800 

Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu
                805                 810                 815 

Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu
            820                 825                 830 

Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala
        835                 840                 845 

Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg
    850                 855                 860 

Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr
865                 870                 875                 880 

Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys
                885                 890                 895 

Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp
            900                 905                 910 

Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp
        915                 920                 925 

Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys
    930                 935                 940 

Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys
945                 950                 955                 960 

Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val
                965                 970                 975 

Met Ser Tyr Leu Asn Ala Ser
            980            


<210>    276
<211>    1016
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12-hu IgG1 Fc-anti-hu CD20 scFv


<400>    276
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        755                 760                 765 

Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly
    770                 775                 780 

Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser
785                 790                 795                 800 

Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp
                805                 810                 815 

Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys
            820                 825                 830 

Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala
        835                 840                 845 

Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr
    850                 855                 860 

Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp
865                 870                 875                 880 

Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly
                885                 890                 895 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile
            900                 905                 910 

Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys
        915                 920                 925 

Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp
    930                 935                 940 

Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr
945                 950                 955                 960 

Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser
                965                 970                 975 

Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala
            980                 985                 990 

Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly
        995                1000                1005 

Gly Gly Thr Lys Leu Glu Ile Lys
   1010                1015    


<210>    277
<211>    1016
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu scIL-12 mut2-hu IgG1 Fc-anti-hu CD20 scFv


<400>    277
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys
                 85                  90                  95 

Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys
            100                 105                 110 

Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr
        115                 120                 125 

Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln
    130                 135                 140 

Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly
145                 150                 155                 160 

Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala
                165                 170                 175 

Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala
            180                 185                 190 

Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg
        195                 200                 205 

Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu
    210                 215                 220 

Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp
225                 230                 235                 240 

Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln
                245                 250                 255 

Gly Ala Ser Ala Arg Glu Ala Ala Asp Arg Val Phe Thr Asp Lys Thr
            260                 265                 270 

Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala
        275                 280                 285 

Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro
    290                 295                 300 

Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
305                 310                 315                 320 

Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys
                325                 330                 335 

Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln
            340                 345                 350 

Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile
        355                 360                 365 

Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys
    370                 375                 380 

Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu
385                 390                 395                 400 

Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
                405                 410                 415 

Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met
            420                 425                 430 

Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro
        435                 440                 445 

Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu
    450                 455                 460 

Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser
465                 470                 475                 480 

Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile
                485                 490                 495 

Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met
            500                 505                 510 

Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        515                 520                 525 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
    530                 535                 540 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
545                 550                 555                 560 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                565                 570                 575 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            580                 585                 590 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        595                 600                 605 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    610                 615                 620 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
625                 630                 635                 640 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                645                 650                 655 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            660                 665                 670 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        675                 680                 685 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    690                 695                 700 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
705                 710                 715                 720 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                725                 730                 735 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            740                 745                 750 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        755                 760                 765 

Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly
    770                 775                 780 

Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser
785                 790                 795                 800 

Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp
                805                 810                 815 

Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys
            820                 825                 830 

Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala
        835                 840                 845 

Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr
    850                 855                 860 

Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp
865                 870                 875                 880 

Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly
                885                 890                 895 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile
            900                 905                 910 

Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys
        915                 920                 925 

Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp
    930                 935                 940 

Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr
945                 950                 955                 960 

Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser
                965                 970                 975 

Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala
            980                 985                 990 

Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly
        995                1000                1005 

Gly Gly Thr Lys Leu Glu Ile Lys
   1010                1015    


<210>    278
<211>    1025
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12-mu IgG2a Fc hole-anti-mu CD20 scFv


<400>    278
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys
                245                 250                 255 

Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Gly Gly Gly Gly Ser
        755                 760                 765 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
    770                 775                 780 

Pro Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys
785                 790                 795                 800 

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys
                805                 810                 815 

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser
            820                 825                 830 

Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu
        835                 840                 845 

Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
    850                 855                 860 

Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Gly Tyr Tyr
865                 870                 875                 880 

Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
                885                 890                 895 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            900                 905                 910 

Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Met Ser Gln Ser Pro Ala
        915                 920                 925 

Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala
    930                 935                 940 

Arg Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Ser
945                 950                 955                 960 

Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val
                965                 970                 975 

Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
            980                 985                 990 

Ile Thr Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
        995                1000                1005 

Trp Ser Ser Lys Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
   1010                1015                1020 

Lys
102


<210>    279
<211>    1025
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2-mu IgG2a Fc hole-anti-mu CD20 scFv


<400>    279
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala Ala Ala
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Ser Cys Ala Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Val Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Gly Gly Gly Gly Ser
        755                 760                 765 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
    770                 775                 780 

Pro Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys
785                 790                 795                 800 

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys
                805                 810                 815 

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser
            820                 825                 830 

Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu
        835                 840                 845 

Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
    850                 855                 860 

Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Gly Tyr Tyr
865                 870                 875                 880 

Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
                885                 890                 895 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            900                 905                 910 

Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Met Ser Gln Ser Pro Ala
        915                 920                 925 

Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala
    930                 935                 940 

Arg Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Ser
945                 950                 955                 960 

Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val
                965                 970                 975 

Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
            980                 985                 990 

Ile Thr Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
        995                1000                1005 

Trp Ser Ser Lys Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
   1010                1015                1020 

Lys
102


<210>    280
<211>    986
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc-mu scIL-12


<400>    280
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    450                 455                 460 

Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp
465                 470                 475                 480 

Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro
                485                 490                 495 

Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile
            500                 505                 510 

Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala
        515                 520                 525 

Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His
    530                 535                 540 

Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu
545                 550                 555                 560 

Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr
                565                 570                 575 

Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu
            580                 585                 590 

Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val
        595                 600                 605 

Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln
    610                 615                 620 

Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys
625                 630                 635                 640 

Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg
                645                 650                 655 

Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp
            660                 665                 670 

Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys
        675                 680                 685 

Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr
    690                 695                 700 

Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys
705                 710                 715                 720 

Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala
                725                 730                 735 

Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn
            740                 745                 750 

Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys
        755                 760                 765 

Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly
    770                 775                 780 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly
785                 790                 795                 800 

Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp
                805                 810                 815 

Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr
            820                 825                 830 

Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr
        835                 840                 845 

Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu
    850                 855                 860 

Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro
865                 870                 875                 880 

Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu
                885                 890                 895 

Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu
            900                 905                 910 

Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val
        915                 920                 925 

Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu
    930                 935                 940 

Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met
945                 950                 955                 960 

Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile
                965                 970                 975 

Asn Arg Val Met Gly Tyr Leu Ser Ser Ala
            980                 985    


<210>    281
<211>    986
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    anti-mu CD20 HC mu IgG2a Fc-mu scIL-12 mut2


<400>    281
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Val Ile Asp Pro Ser Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Glu Gly Tyr Tyr Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser
        115                 120                 125 

Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val
    130                 135                 140 

Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu
145                 150                 155                 160 

Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr
            180                 185                 190 

Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro
        195                 200                 205 

Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
    210                 215                 220 

Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met
                245                 250                 255 

Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu
            260                 265                 270 

Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val
        275                 280                 285 

His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu
    290                 295                 300 

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly
305                 310                 315                 320 

Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
            340                 345                 350 

Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr
        355                 360                 365 

Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu
    370                 375                 380 

Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val
                405                 410                 415 

Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val
            420                 425                 430 

His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr
        435                 440                 445 

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    450                 455                 460 

Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp
465                 470                 475                 480 

Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro
                485                 490                 495 

Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile
            500                 505                 510 

Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala
        515                 520                 525 

Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His
    530                 535                 540 

Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu
545                 550                 555                 560 

Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr
                565                 570                 575 

Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu
            580                 585                 590 

Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val
        595                 600                 605 

Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln
    610                 615                 620 

Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys
625                 630                 635                 640 

Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg
                645                 650                 655 

Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp
            660                 665                 670 

Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys
        675                 680                 685 

Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr
    690                 695                 700 

Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala Ala
705                 710                 715                 720 

Ala Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala
                725                 730                 735 

Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn
            740                 745                 750 

Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys
        755                 760                 765 

Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly
    770                 775                 780 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly
785                 790                 795                 800 

Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp
                805                 810                 815 

Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr
            820                 825                 830 

Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr
        835                 840                 845 

Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu
    850                 855                 860 

Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro
865                 870                 875                 880 

Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu
                885                 890                 895 

Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu
            900                 905                 910 

Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val
        915                 920                 925 

Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu
    930                 935                 940 

Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met
945                 950                 955                 960 

Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile
                965                 970                 975 

Asn Arg Val Met Gly Tyr Leu Ser Ser Ala
            980                 985    


<210>    282
<211>    1025
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12-mu IgG2a Fc-anti-mu CD20 scFv


<400>    282
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys
                245                 250                 255 

Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Gly Gly Gly Gly Ser
        755                 760                 765 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
    770                 775                 780 

Pro Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys
785                 790                 795                 800 

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys
                805                 810                 815 

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser
            820                 825                 830 

Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu
        835                 840                 845 

Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
    850                 855                 860 

Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Gly Tyr Tyr
865                 870                 875                 880 

Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
                885                 890                 895 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            900                 905                 910 

Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Met Ser Gln Ser Pro Ala
        915                 920                 925 

Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala
    930                 935                 940 

Arg Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Ser
945                 950                 955                 960 

Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val
                965                 970                 975 

Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
            980                 985                 990 

Ile Thr Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
        995                1000                1005 

Trp Ser Ser Lys Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
   1010                1015                1020 

Lys
102


<210>    283
<211>    1025
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu scIL-12 mut2-mu IgG2a Fc-anti-mu CD20 scFv


<400>    283
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr
  1               5                  10                  15 

Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu
             20                  25                  30 

Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly
         35                  40                  45 

Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly
     50                  55                  60 

Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu
 65                  70                  75                  80 

Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys
                 85                  90                  95 

Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser
            100                 105                 110 

Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys
        115                 120                 125 

Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr
    130                 135                 140 

Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg
145                 150                 155                 160 

Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro
                165                 170                 175 

Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln
            180                 185                 190 

Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile
        195                 200                 205 

Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn
    210                 215                 220 

Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro
225                 230                 235                 240 

His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Ala Ala Ala
                245                 250                 255 

Glu Lys Met Ala Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe
            260                 265                 270 

Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val
        275                 280                 285 

Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp
    290                 295                 300 

Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly
305                 310                 315                 320 

Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro
                325                 330                 335 

Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp
            340                 345                 350 

Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala
        355                 360                 365 

Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu
    370                 375                 380 

Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala
385                 390                 395                 400 

Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln
                405                 410                 415 

Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp
            420                 425                 430 

Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln
        435                 440                 445 

Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala
    450                 455                 460 

Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg
465                 470                 475                 480 

Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys
                485                 490                 495 

Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn
            500                 505                 510 

Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly
        515                 520                 525 

Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
    530                 535                 540 

Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe
545                 550                 555                 560 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
                565                 570                 575 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
            580                 585                 590 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
        595                 600                 605 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
    610                 615                 620 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val
625                 630                 635                 640 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
                645                 650                 655 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
            660                 665                 670 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp
        675                 680                 685 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
    690                 695                 700 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
705                 710                 715                 720 

Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
                725                 730                 735 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
            740                 745                 750 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Gly Gly Gly Gly Ser
        755                 760                 765 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
    770                 775                 780 

Pro Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys
785                 790                 795                 800 

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys
                805                 810                 815 

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asp Pro Ser
            820                 825                 830 

Asp Asn Tyr Thr Lys Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu
        835                 840                 845 

Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
    850                 855                 860 

Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Gly Tyr Tyr
865                 870                 875                 880 

Gly Ser Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
                885                 890                 895 

Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            900                 905                 910 

Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Met Ser Gln Ser Pro Ala
        915                 920                 925 

Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala
    930                 935                 940 

Arg Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Ser
945                 950                 955                 960 

Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val
                965                 970                 975 

Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
            980                 985                 990 

Ile Thr Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
        995                1000                1005 

Trp Ser Ser Lys Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
   1010                1015                1020 

Lys
102


<210>    284
<211>    227
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    hu IgG1 Fc


<400>    284
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
  1               5                  10                  15 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
             20                  25                  30 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
         35                  40                  45 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
     50                  55                  60 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
 65                  70                  75                  80 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                 85                  90                  95 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            100                 105                 110 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        115                 120                 125 

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
    130                 135                 140 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
145                 150                 155                 160 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                165                 170                 175 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            180                 185                 190 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        195                 200                 205 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    210                 215                 220 

Pro Gly Lys
225        


<210>    285
<211>    233
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mu IgG2a Fc


<400>    285
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
  1               5                  10                  15 

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
             20                  25                  30 

Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
         35                  40                  45 

Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
     50                  55                  60 

Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
 65                  70                  75                  80 

Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
                 85                  90                  95 

Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
            100                 105                 110 

Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser
        115                 120                 125 

Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met
    130                 135                 140 

Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro
145                 150                 155                 160 

Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn
                165                 170                 175 

Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met
            180                 185                 190 

Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser
        195                 200                 205 

Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr
    210                 215                 220 

Lys Ser Phe Ser Arg Thr Pro Gly Lys
225                 230            
