(19)

(11)

EP 4 203 987 A2

(12)

(88) Date of publication A3: 14.04.2022 (43) Date of publication: 05.07.2023 Bulletin 2023/27 (21) Application number: 21862665.3 (22) Date of filing: 25.08.2021

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) A61P 29/00(2006.01) A61K 38/17(2006.01) A61P 3/06(2006.01) (52) Cooperative Patent Classification (CPC): A01K 2217/075; A01K 2227/105; A01K 2267/0368; A01K 2267/0306; A61K 9/0048; A61K 38/1709 (86) International application number: PCT/US2021/047569 (87) International publication number: WO 2022/046919 (03.03.2022 Gazette 2022/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 25.08.2020 US 202063070145 P (71) Applicant: The Regents of the University of California Oakland, CA 94607 (US)	(72) Inventors: MILLER, Yury La Jolla, California 92093 (US) CHOI, Soo-Ho La Jolla, California 92093 (US) JU, Wonkyu La Jolla, California 92093 (US) (74) Representative: Ghirardi, Valeria et al De Simone & Partners S.r.l. Via Vincenzo Bellini, 20 00198 Roma 00198 Roma (IT)