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EP 4 208 196 A1

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(43) Date of publication: 12.07.2023 Bulletin 2023/28 (21) Application number: 21778670.6 (22) Date of filing: 03.09.2021

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) A61K 39/215(2006.01) A61P 31/16(2006.01) C12N 15/63(2006.01) A61K 39/145(2006.01) A61P 31/14(2006.01) C12N 15/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/12; A61K 39/215; A61P 31/16; A61K 39/145; A61P 31/14; A61K 2039/53; A61K 2039/55555; A61K 2039/70; C12N 2760/16134; C12N 2770/20034; C12N 2840/203; C12N 15/85; C12N 2840/206 (86) International application number: PCT/US2021/049077 (87) International publication number: WO 2022/051629 (10.03.2022 Gazette 2022/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.09.2020 US 202063074428 P 15.12.2020 US 202063125769 P 20.05.2021 US 202163191020 P (71) Applicant: Flagship Pioneering Innovations VI, LLC Cambridge, MA 02142 (US)

(72) Inventors: KAHVEJIAN, Avak Cambridge, MA 02142 (US) DE BOER, Alexandra Sophie Cambridge, MA 02142 (US) ECHELARD, Yann Paul Guy Régis Cambridge, MA 02142 (US) PLUGIS, Nicholas McCartney Cambridge, MA 02142 (US) WEINSTEIN, Erica Gabrielle Cambridge, MA 02142 (US) NELSON, Jennifer A. Cambridge, MA 02142 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)