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EP 4 210 686 A1

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(43) Date of publication: 19.07.2023 Bulletin 2023/29 (21) Application number: 21773100.9 (22) Date of filing: 08.09.2021

(51) International Patent Classification (IPC):  A61K 31/137(2006.01) A61K 31/4245(2006.01) A61K 31/4468(2006.01) A61K 31/496(2006.01) A61K 31/513(2006.01) A61K 31/7105(2006.01) A61P 9/00(2006.01) A61K 31/27(2006.01) A61K 31/445(2006.01) A61K 31/495(2006.01) A61K 31/506(2006.01) A61K 31/5375(2006.01) A61K 45/06(2006.01) A61P 9/10(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/4468; A61K 31/445; A61K 31/137; A61K 31/5375; A61K 31/495; A61K 31/496; A61K 31/513; A61K 31/4245; A61K 31/27; A61K 31/506; A61K 31/7105; A61K 45/06; A61P 9/00; A61P 9/10   C-Sets: A61K 31/4468, A61K 2300/00; A61K 31/495, A61K 2300/00; A61K 31/496, A61K 2300/00; A61K 31/506, A61K 2300/00; A61K 31/513, A61K 2300/00; A61K 31/137, A61K 2300/00; A61K 31/7105, A61K 2300/00; A61K 31/27, A61K 2300/00; A61K 31/5375, A61K 2300/00; A61K 31/4245, A61K 2300/00; A61K 31/445, A61K 2300/00; (86) International application number: PCT/EP2021/074718 (87) International publication number: WO 2022/053520 (17.03.2022 Gazette 2022/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.09.2020 EP 20305993 (71) Applicants: Université d'Aix-Marseille 13007 Marseille (FR) Institut National de la Santé et de la Recherche Médicale 75013 Paris (FR)

(72) Inventor: PUCEAT, Michel 13014 Marseille (FR) (74) Representative: LLR  11, boulevard de Sébastopol 75001 Paris 75001 Paris (FR)