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EP 4 211 151 A1

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(43) Date of publication: 19.07.2023 Bulletin 2023/29 (21) Application number: 21867807.6 (22) Date of filing: 14.09.2021

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) C12N 15/864(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2830/48; C12N 2830/50; C12N 2750/14143; C12N 2830/008; C07K 14/47 (86) International application number: PCT/US2021/050205 (87) International publication number: WO 2022/056444 (17.03.2022 Gazette 2022/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.09.2020 US 202063078233 P 16.03.2021 US 202163161619 P (71) Applicant: President and Fellows of Harvard College Cambridge, MA 02138 (US)

(72) Inventors: COREY, David, P. Cambridge, MA 02138 (US) BOOTH, Kevin, T. Cambridge, MA 02138 (US) PETERS, Cole, W., D. Cambridge, MA 02138 (US) IVANCHENKO, Maryna, V. Cambridge, MA 02138 (US) GREENBERG, Michael, E. Cambridge, MA 02138 (US) HRVATIN, Sinisa Cambridge, MA 02138 (US) NAGY, Mark, Aurel Cambridge, MA 02138 (US) GRIFFITH, Eric, C. Cambridge, MA 02138 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)