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EP 4 213 996 A1

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(43) Date of publication: 26.07.2023 Bulletin 2023/30 (21) Application number: 21869878.5 (22) Date of filing: 17.09.2021

(51) International Patent Classification (IPC):  B03C 1/28(2006.01) C12Q 1/6806(2018.01) C12N 15/10(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1013; B03C 1/288; B03C 2201/26; B03C 2201/18; B03C 1/01; B03C 1/0332; B03C 1/30 (86) International application number: PCT/SG2021/050567 (87) International publication number: WO 2022/060301 (24.03.2022 Gazette 2022/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 18.09.2020 SG 10202009183S (71) Applicant: Agency for Science, Technology and Research Singapore 138632 (SG)

(72) Inventors: WANG, Wei Singapore Institute of Manufacturing Technology 2 Fusionopolis Way 08-04, Innovis Singapore 138634 (SG) WANG, Zhiping Singapore Institute of Manufacturing Technology 2 Fusionopolis Way 08-04, Innovis Singapore 138634 (SG) ZENG, Jiamin, Jasmine Singapore Institute of Manufacturing Technology 2 Fusionopolis Way 08-04, Innovis Singapore 138634 (SG) LIU, Feng Singapore Institute of Manufacturing Technology 2 Fusionopolis Way 08-04, Innovis Singapore 138634 (SG) (74) Representative: Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte  Am Brauhaus 8 01099 Dresden 01099 Dresden (DE)