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EP 4 216 928 A1

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(43) Date of publication: 02.08.2023 Bulletin 2023/31 (21) Application number: 21801233.4 (22) Date of filing: 13.09.2021

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 9/19(2006.01) A61K 47/02(2006.01) A61K 47/18(2017.01) A61P 7/00(2006.01) A61K 9/08(2006.01) A61K 38/00(2006.01) A61K 47/12(2006.01) A61K 47/26(2006.01) A61K 47/42(2017.01) (52) Cooperative Patent Classification (CPC): A61K 9/0019; A61K 9/08; A61K 9/19; A61K 38/36; A61K 38/4833; A61K 38/4846; A61K 38/4866; A61K 38/57; A61K 47/02; A61K 47/12; A61K 47/183; A61K 47/26; A61K 47/42; A61P 7/00   C-Sets: A61K 38/57, A61K 2300/00; A61K 38/36, A61K 2300/00; A61K 38/4846, A61K 2300/00; A61K 38/4833, A61K 2300/00; A61K 38/4866, A61K 2300/00; (86) International application number: PCT/IL2021/051112 (87) International publication number: WO 2022/064478 (31.03.2022 Gazette 2022/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 23.09.2020 IL 27754320 23.09.2020 US 202063082029 P (71) Applicant: Omrix Biopharmaceuticals Ltd. Rehovot 7610601 (IL)	(72) Inventors: NUR, Israel 7403769 Nes-Ziona (IL) MINTZ, Roni 7951500 Moshav Shafir (IL) VISNOVEZKY, Damian 6802370 Tel Aviv-Yafo (IL) YUNUSOV, Marina 5867174 Holon (IL) LESHETS, Michael 5238284 Ramat Gan (IL) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)