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(11)

EP 4 216 961 A1

(12)

(43) Date of publication: 02.08.2023 Bulletin 2023/31 (21) Application number: 21873358.2 (22) Date of filing: 22.09.2021

(51) International Patent Classification (IPC):  A61K 31/7056(2006.01) A61K 31/706(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/12; C07D 403/12; C07D 207/26; C07D 405/12; C07D 413/14; C07D 401/14; A61P 25/00 (86) International application number: PCT/US2021/051564 (87) International publication number: WO 2022/066776 (31.03.2022 Gazette 2022/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 23.09.2020 US 202063082305 P (71) Applicant: Lighthouse Pharmaceuticals, Inc. San Francisco, CA 94131 (US)	(72) Inventors: VACCA, Joseph San Francisco, California 94080 (US) HOLSINGER, Leslie J. San Francisco, California 94080 (US) LYNCH, Casey C. San Francisco, California 94080 (US) DOMINY, Stephen S. San Francisco, California 94080 (US) ERMINI, Florian San Francisco, California 94080 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)