(19)

(11)

EP 4 217 744 A1

(12)

(43) Date of publication: 02.08.2023 Bulletin 2023/31 (21) Application number: 21873644.5 (22) Date of filing: 28.09.2021

(51) International Patent Classification (IPC):  G01N 33/564(2006.01) G01N 33/58(2006.01) C07K 16/28(2006.01) G01N 33/50(2006.01) G01N 33/558(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/564; G01N 2333/4716; C07K 16/18; C07K 2317/30 (86) International application number: PCT/US2021/052437 (87) International publication number: WO 2022/067259 (31.03.2022 Gazette 2022/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.09.2020 US 202063084432 P 27.09.2021 US 202163248962 P (71) Applicant: Allegheny Singer Research Institute Pittsburgh, PA 15212 (US)	(72) Inventors: AHEARN, Joseph M. Wexford, Pennsylvania 15090 (US) LIU, Chau-Ching Pittsburgh, Pennsylvania (US) (74) Representative: Harrison IP Limited  3 Ebor House Millfield Lane Nether Poppleton, York YO26 6QY Nether Poppleton, York YO26 6QY (GB)