(19)

(11)

EP 4 221 757 A1

(12)

(43) Date of publication: 09.08.2023 Bulletin 2023/32 (21) Application number: 21786122.8 (22) Date of filing: 27.09.2021

(51) International Patent Classification (IPC):  A61K 47/62(2017.01) A61K 49/18(2006.01) A61K 51/12(2006.01) A61K 31/704(2006.01) A61K 48/00(2006.01) A61P 31/18(2006.01) A61K 47/69(2017.01) A61K 49/00(2006.01) A61K 31/573(2006.01) A61K 38/16(2006.01) A61P 25/00(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/62; A61K 47/6911; A61K 49/0056; A61K 49/006; A61K 49/0084; A61K 49/1812; A61K 51/1234; A61P 25/00; A61P 31/18; A61P 35/00; A61K 31/573; A61K 31/704; A61K 9/1272; A61K 9/0019; A61K 38/00 (86) International application number: PCT/EP2021/076545 (87) International publication number: WO 2022/069419 (07.04.2022 Gazette 2022/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.09.2020 NL 2026569 08.02.2021 NL 2027516 19.02.2021 NL 2027601 (71) Applicant: CRM Therapeutics B.V. 3047 AK Rotterdam (NL)	(72) Inventors: BOER, DE, Albertus Gerrit 2317 HV Leiden (NL) MARING, Markwin Hendrik 3047AC Rotterdam (NL) (74) Representative: Patent Business B.V.  Lange Amerikaweg 81 7332 BP Apeldoorn 7332 BP Apeldoorn (NL)