(19)

(11)

EP 4 225 421 A1

(12)

(43) Date of publication: 16.08.2023 Bulletin 2023/33 (21) Application number: 21878399.1 (22) Date of filing: 05.10.2021

(51) International Patent Classification (IPC):  A61M 35/00(2006.01) A61F 13/40(2006.01) A61B 17/00(2006.01) B65D 83/00(2006.01) (52) Cooperative Patent Classification (CPC): A61M 35/006; A61B 2017/00898; A61B 2017/00893; A61B 17/132; A61B 2090/037 (86) International application number: PCT/US2021/053641 (87) International publication number: WO 2022/076467 (14.04.2022 Gazette 2022/15)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 05.10.2020 US 202063087532 P 13.10.2020 US 202063090768 P 09.04.2021 WO PCT/US2021/026714 (71) Applicant: BIO 54, LLC Chapel Hill, NC 27514 (US)	(72) Inventors: MANASCO, Anton Travis Chapel Hill, North Carolina 27514 (US) POWELL, Margaret Booth Chapel Hill, North Carolina 27514 (US) GRANKO, Hazar Awad Chapel Hill, North Carolina 27514 (US) (74) Representative: Cooley (UK) LLP  22 Bishopsgate London EC2N 4BQ London EC2N 4BQ (GB)