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EP 4 225 895 A1

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(43) Date of publication: 16.08.2023 Bulletin 2023/33 (21) Application number: 21794692.0 (22) Date of filing: 05.10.2021

(51) International Patent Classification (IPC):  C12N 1/20(2006.01) C07D 213/90(2006.01) A01N 63/27(2020.01) (52) Cooperative Patent Classification (CPC): A01N 43/40; A01N 63/27; A01P 1/00; C07D 213/90; C12N 1/205; C12R 2001/38; Y02A 40/81   C-Sets: A01N 63/27, A01N 43/40; (86) International application number: PCT/US2021/053482 (87) International publication number: WO 2022/076351 (14.04.2022 Gazette 2022/15)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 05.10.2020 AR P200102757 05.10.2020 WO PCT/US2020/054303 05.10.2020 TW 109134454 05.10.2020 US 202017063540 04.10.2021 WO PCT/US2021/053405 04.10.2021 US 202117493594 (71) Applicants: T3 Bioscience, LLC Mequon, WI 53092-6120 (US) UWM Research Foundation, Inc. Milwaukee, WI 53202 (US)

(72) Inventors: YANG, Ching-Hong Mequon, WI 53902 (US) HUANG, Jian Milwaukee, WI 53212 (US) (74) Representative: Modiano, Gabriella Diana et al Modiano & Partners (DE) Steinsdorfstrasse, 14 80538 München 80538 München (DE)