(19)
(11) EP 4 229 033 A1

(12)

(43) Date of publication:
23.08.2023 Bulletin 2023/34

(21) Application number: 21805779.2

(22) Date of filing: 15.10.2021
(51) International Patent Classification (IPC): 
C07C 253/30(2006.01)
C07C 29/62(2006.01)
C07C 35/32(2006.01)
 C07C 29/38(2006.01)
C07C 255/54(2006.01)
C07C 35/52(2006.01)
(52) Cooperative Patent Classification (CPC):
C07C 253/30; C07C 2603/10; C07B 2200/07; C07C 29/38; C07C 2602/08; C07C 29/62; C07C 45/40; C07C 45/673
 
C-Sets:
  1. C07C 45/673, C07C 49/737;
  2. C07C 253/30, C07C 255/54;
  3. C07C 29/38, C07C 35/32;
  4. C07C 29/62, C07C 35/52;
  5. C07C 45/40, C07C 49/737;
(86) International application number:
PCT/US2021/055295
(87) International publication number:
WO 2022/086822 (28.04.2022 Gazette 2022/17)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 19.10.2020 WO PCT/CN2020/121745

(71) Applicant: Nikang Therapeutics, Inc.
Wilmington DE 19803 (US)

(72) Inventors:
  • FU, Jiping
    Wilmington, Delaware 19803 (US)
  • LOU, Yan
    Wilmington, Delaware 19803 (US)
  • HE, Yigang
    Wilmington, Delaware 19803 (US)
  • SHI, Yuetao
    Chunjiang, Jiangsu 213127 (CN)
  • ZHOU, Peng
    Chunjiang, Jiangsu 213127 (CN)
  • LI, Xingxing
    Chunjiang, Jiangsu 213127 (CN)

(74) Representative: Carpmaels & Ransford LLP 
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


(54) PROCESSES OF PREPARING 3-FLUORO-5-(((1S,2AR)-1,3,3,4,4-PENTAFLUORO-2A-HYDROXY-2,2A,3,4-TETRAHYDRO-1H-CYCLOPENTA[CD]INDEN-7-YL)OXY)-BENZONITRILE