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EP 4 232 049 A1

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(43) Date of publication: 30.08.2023 Bulletin 2023/35 (21) Application number: 21887358.6 (22) Date of filing: 26.10.2021

(51) International Patent Classification (IPC):  A61K 35/12(2015.01) C12N 5/10(2006.01) C12N 15/11(2006.01) A61K 35/17(2015.01) C12N 9/22(2006.01) C12N 15/63(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/17; C12N 9/22; C12N 15/11; C12N 15/102; C12N 2310/20; A61K 35/28; A61K 35/545; C07K 14/7051; C07K 2319/03 (86) International application number: PCT/US2021/056689 (87) International publication number: WO 2022/093846 (05.05.2022 Gazette 2022/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 26.10.2020 US 202063105834 P 26.01.2021 US 202163141926 P 23.04.2021 US 202163179143 P (71) Applicant: Arsenal Biosciences, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: ZHENG, Xinying San Francisco, California 94080 (US) GALVIN, Brendan San Francisco, California 94080 (US) KHARE, Somya San Francisco, California 94080 (US) COOPER, Aaron San Francisco, California 94080 (US) NGUYEN, Michelle San Francisco, California 94080 (US) YAO, Anzhi San Francisco, California 94080 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)