(19)

(11)

EP 4 232 149 A2

(12)

(88) Date of publication A3: 30.06.2022 (43) Date of publication: 30.08.2023 Bulletin 2023/35 (21) Application number: 21882226.0 (22) Date of filing: 20.10.2021

(51) International Patent Classification (IPC):  A61P 17/00(2006.01) C07D 413/14(2006.01) A61P 27/02(2006.01) (52) Cooperative Patent Classification (CPC): A61P 17/00; A61P 27/02; C07H 17/00 (86) International application number: PCT/IB2021/000707 (87) International publication number: WO 2022/084738 (28.04.2022 Gazette 2022/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.10.2020 US 202063094793 P 05.04.2021 US 202163170988 P (71) Applicant: AZURA OPHTHALMICS LTD 6314305 Tel Aviv (IL)

(72) Inventors: HOLMES, Ian Melbourne (AU) ALSTER, Yair 6314305 Tel Aviv (IL) BARASH, Hila 6314305 Tel Aviv (IL) BOSWORTH, Charles 6314305 Tel Aviv (IL) RAFAELI, Omer 6314305 Tel Aviv (IL) BURK, Robert, M. 6314305 Tel Aviv (IL) GLEESON, Marc Melbourne (AU) STEWART, Mark, Richard Walden, Essex CB10 1XL (GB) DUNN, Jonathan Walden, Essex CB10 1XL (GB) NICHOLLS, Alexander, James Walden, Essex CB10 1XL (GB) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)