(19)
(11) EP 4 233 697 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
27.09.2023 Bulletin 2023/39

(43) Date of publication A2:
30.08.2023 Bulletin 2023/35

(21) Application number: 23178946.2

(22) Date of filing: 19.06.2019
(51) International Patent Classification (IPC): 
A61B 5/02(2006.01)
A61B 5/029(2006.01)
A61B 5/00(2006.01)
A61M 60/216(2021.01)
A61M 60/515(2021.01)
A61M 60/538(2021.01)
 A61B 5/0215(2006.01)
A61B 5/021(2006.01)
A61M 60/13(2021.01)
A61M 60/411(2021.01)
A61M 60/531(2021.01)
A61M 60/523(2021.01)
(52) Cooperative Patent Classification (CPC):
A61B 5/02007; A61B 5/02108; A61B 5/02116; A61B 5/02133; A61B 5/0215; A61B 5/029; A61B 5/4836; A61B 5/686; A61B 5/6869; A61B 5/6876; A61M 2205/3331; A61M 2205/3365; A61M 60/13; A61M 60/411; A61M 60/216; A61M 60/538; A61M 60/523; A61M 60/531; A61M 60/515
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 19.06.2018 US 201862687133 P
18.06.2019 US 201962863146 P
18.06.2019 US 201962863136 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
19737944.9 / 3809959

(71) Applicants:
  • Abiomed, Inc.
    Danvers, MA 01923 (US)
  • Massachusetts Institute Of Technology
    Cambridge, MA 02139 (US)
  • The Brigham and Women's Hospital, Inc.
    Boston, MA 02115 (US)

(72) Inventors:
  • BHAVSAR, Sonya Sanat
    Danvers, 01923 (US)
  • JOSEPHY, Noam
    Danvers, 01923 (US)
  • EDELMAN, Elazer R.
    Cambridge, 02139 (US)
  • CHANG, Brian Yale
    Cambridge, 02139 (US)
  • KELLER, Steven
    Cambridge, 02139 (US)
  • EL KATERJI, Ahmad
    Danvers, 01923 (US)
  • TAN, Qing
    Danvers, 01923 (US)
  • MOYER, Christian
    Danvers, 01923 (US)
  • SHIP, Alexander
    Danvers, 01923 (US)

(74) Representative: Klunker IP Patentanwälte PartG mbB 
Destouchesstraße 68
80796 München
80796 München (DE)

   


(54) SYSTEMS FOR DETERMINING CARDIAC PERFORMANCE


(57) The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.







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