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(11)

EP 4 236 776 A1

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(43) Date of publication: 06.09.2023 Bulletin 2023/36 (21) Application number: 21887763.7 (22) Date of filing: 02.11.2021

(51) International Patent Classification (IPC):  A61B 5/0205(2006.01) A61B 5/11(2006.01) A61B 5/00(2006.01) A61B 5/113(2006.01) A61B 5/08(2006.01) (52) Cooperative Patent Classification (CPC): A61B 5/113; A61B 5/02055; A61B 5/1102; A61B 5/0823; A61B 5/4205; A61B 5/4803; A61B 5/7214; A61B 2562/0219; A61B 5/6833; A61B 5/6822 (86) International application number: PCT/US2021/057686 (87) International publication number: WO 2022/094451 (05.05.2022 Gazette 2022/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 02.11.2020 US 202063108514 P (71) Applicant: Northwestern University Evanston, IL 60208 (US)	(72) Inventors: XU, Shuai Bala Cynwyd, Pennsylvania 19004 (US) JEONG, Hyoyoung Evanston, Illinois 60208 (US) LEE, Jong Yoon Evanston, Illinois 60208 (US) LEE, Kun Hyuck Evanston, Illinois 60208 (US) ROGERS, John A. Wilmette, Illinois 60091 (US) (74) Representative: Heubeck, Christian  Weickmann & Weickmann Patent- und Rechtsanwälte PartmbB Postfach 860 820 81635 München 81635 München (DE)