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(11)

EP 4 240 279 A1

(12)

(43) Date of publication: 13.09.2023 Bulletin 2023/37 (21) Application number: 21890078.5 (22) Date of filing: 04.11.2021

(51) International Patent Classification (IPC):  A61F 2/04(2013.01) A61K 35/30(2015.01) C12N 5/00(2006.01) F04B 43/08(2006.01) A61F 2/07(2013.01) B01L 3/00(2006.01) F04B 43/02(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/30; C12N 2535/00; C12N 2513/00; C12N 5/0697; C12N 5/0618; C12N 5/0068 (86) International application number: PCT/US2021/058090 (87) International publication number: WO 2022/098895 (12.05.2022 Gazette 2022/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.11.2020 US 202063109407 P (71) Applicant: The Regents Of The University Of Michigan Ann Arbor, Michigan 48109 (US)	(72) Inventors: XUE, Xufeng Ann Arbor, Michigan 48109-2590 (US) FU, Jianping Ann Arbor, Michigan 48109-2590 (US) TANG, Huaijing Ann Arbor, Michigan 48109-2590 (US) (74) Representative: Glawe, Delfs, Moll  Partnerschaft mbB von Patent- und Rechtsanwälten Postfach 13 03 91 20103 Hamburg 20103 Hamburg (DE)