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(11)

EP 4 240 294 A1

(12)

(43) Date of publication: 13.09.2023 Bulletin 2023/37 (21) Application number: 21889724.7 (22) Date of filing: 19.10.2021

(51) International Patent Classification (IPC):  A61F 5/00(2006.01) A61M 31/00(2006.01) A61B 34/00(2016.01) (52) Cooperative Patent Classification (CPC): A61F 5/0076; A61B 2034/2051; A61B 2090/3954; A61B 2090/3958; A61B 34/20; A61B 34/73; A61B 5/062; A61B 2017/00876; A61B 5/6861; A61B 5/687 (86) International application number: PCT/SG2021/050630 (87) International publication number: WO 2022/098296 (12.05.2022 Gazette 2022/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.11.2020 SG 10202010982R (71) Applicant: Nanyang Technological University Singapore 639798 (SG)	(72) Inventors: MIYASAKA, Muneaki Singapore 639798 (SG) PHEE, Soo Jay, Louis Singapore 639798 (SG) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)