(19)

(11)

EP 4 240 327 A1

(12)

(43) Date of publication: 13.09.2023 Bulletin 2023/37 (21) Application number: 21889999.5 (22) Date of filing: 03.11.2021

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 38/17(2006.01) A61K 39/395(2006.01) A61K 9/70(2006.01) A61K 38/39(2006.01) A61K 45/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 5/0062; C12N 5/0068; C12N 2501/905; C12N 2501/998; C12N 2537/10 (86) International application number: PCT/US2021/057925 (87) International publication number: WO 2022/098777 (12.05.2022 Gazette 2022/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 06.11.2020 US 202063110667 P (71) Applicant: The Board of Trustees of the Leland Stanford Junior University Stanford, CA 94305-2038 (US)	(72) Inventors: HEILSHORN, Sarah Mountain View, California 94040 (US) SUHAR, Riley Redwood City, California 94063 (US) HUNT, Daniel Redwood City, California 94063 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)