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EP 4 240 330 A1

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(43) Date of publication: 13.09.2023 Bulletin 2023/37 (21) Application number: 21888591.1 (22) Date of filing: 03.11.2021

(51) International Patent Classification (IPC):  A61K 9/14(2006.01) A61K 47/38(2006.01) A61K 9/36(2006.01) A61P 35/02(2006.01) A61K 31/404(2006.01) A61K 47/32(2006.01) A61P 35/00(2006.01) A61P 35/04(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/146; A61K 9/2054; A61K 9/2009; A61K 31/404 (86) International application number: PCT/CN2021/128402 (87) International publication number: WO 2022/095894 (12.05.2022 Gazette 2022/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.11.2020 CN 202011206371 (71) Applicants: Shanghai Yasheng Pharmaceutical Technology Co., Ltd. Shanghai 201203 (CN) Ascentage Pharma (Suzhou) Co., Ltd. Suzhou, Jiangsu 215028 (CN) Ascentage Pharma Group Corp Limited Hong Kong 999077 (HK)

(72) Inventors: LIN, Yanqiong Shanghai 201203 (CN) XU, Hualiang Shanghai 201203 (CN) GUO, Hongtao Shanghai 201203 (CN) (74) Representative: Plasseraud IP  66, rue de la Chaussée d'Antin 75440 Paris Cedex 09 75440 Paris Cedex 09 (FR)