(19)

(11)

EP 4 240 394 A2

(12)

(88) Date of publication A3: 14.07.2022 (43) Date of publication: 13.09.2023 Bulletin 2023/37 (21) Application number: 21890074.4 (22) Date of filing: 04.11.2021

(51) International Patent Classification (IPC):  A61K 38/10(2006.01) A61P 37/04(2006.01) C07K 7/08(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/7155; C07K 14/55 (86) International application number: PCT/US2021/058085 (87) International publication number: WO 2022/098890 (12.05.2022 Gazette 2022/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.11.2020 US 202017089515 (60) Divisional application: 23187951.1 (71) Applicant: Medikine, Inc. Menlo Park CA 94025 (US)	(72) Inventors: DOWER, William J. Menlo Park, CA 94025 (US) NEEDELS, Michael C. Menlo Park, CA 94025 (US) BARRETT, Ronald W. Menlo Park, CA 94025 (US) BAKKER, Alice V. Menlo Park, CA 94025 (US) CWIRLA, Steven E. Menlo Park, CA 94025 (US) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)