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EP 4 240 849 A1

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(43) Date of publication: 13.09.2023 Bulletin 2023/37 (21) Application number: 21890258.3 (22) Date of filing: 08.11.2021

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) C07H 21/02(2006.01) C12N 9/22(2006.01) (52) Cooperative Patent Classification (CPC): C07H 21/02; C12N 2310/11; C12N 2310/315; C12N 2310/321; C12N 2310/322; C12N 2310/335; C12N 2310/334; C12N 2320/33; C12N 15/113; C12N 9/78; C12Y 305/04; C07H 21/04   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; (86) International application number: PCT/US2021/058495 (87) International publication number: WO 2022/099159 (12.05.2022 Gazette 2022/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.11.2020 US 202063111079 P 14.04.2021 US 202163175036 P 13.05.2021 US 202163188415 P 02.06.2021 US 202163196178 P 26.09.2021 US 202163248520 P (71) Applicant: Wave Life Sciences Ltd. Singapore 018936 (SG)

(72) Inventors: MONIAN, Prashant Cambridge, Massachusetts 02138 (US) SHIVALILA, Chikdu Shakti Cambridge, Massachusetts 02138 (US) MARAPPAN, Subramanian Cambridge, Massachusetts 02138 (US) VARGEESE, Chandra Concord Avenue Cambrdige, Massachusetts 02138 (US) KANDASAMY, Pachamuthu Cambridge, Massachusetts 02138 (US) LU, Genliang Cambridge, Massachusetts 02138 (US) YU, Hui Cambridge, Massachusetts 02138 (US) BUTLER, David Charles Donnell Cambridge, Massachusetts 02138 (US) APPONI, Luciano Henrique Cambridge, Massachusetts 02138 (US) SHIMIZU, Mamoru Cambridge, Massachusetts 02138 (US) STANDLEY, Stephany Michelle Cambridge, Massachusetts 02138 (US) BOULAY, David John Cambridge, Massachusetts 02138 (US) HOSS, Andrew Guzior Cambridge, Massachusetts 02138 (US) DESAI, Jigar Cambridge, Massachusetts 02138 (US) GODFREY, Jack David Cambridge, Massachusetts 02138 (US) YANG, Hailin Cambridge, Massachusetts 02138 (US) IWAMOTO, Naoki Cambridge, Massachusetts 02138 (US) KUMARASAMY, Jayakanthan Cambridge, Massachusetts 02138 (US) LAMATTINA, Anthony Cambridge, Massachusetts 02138 (US) PU, Tom Liantang Cambridge, Massachusetts 02138 (US) (74) Representative: Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB  Ganghoferstraße 68 B 80339 München 80339 München (DE)