(19)
(11) EP 4 243 849 A1

(12)

(43) Date of publication:
20.09.2023 Bulletin 2023/38

(21) Application number: 21762369.3

(22) Date of filing: 04.08.2021
(51) International Patent Classification (IPC): 
A61K 35/768(2015.01)
C12N 15/86(2006.01)
C12N 15/113(2010.01)
(52) Cooperative Patent Classification (CPC):
A61K 35/768; C12N 2770/32332; C12N 2770/32343; C12N 2310/141
(86) International application number:
PCT/EP2021/071767
(87) International publication number:
WO 2022/100898 (19.05.2022 Gazette 2022/20)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 13.11.2020 DE 102020130072

(71) Applicant: Technische Universität Berlin
10623 Berlin (DE)

(72) Inventors:
  • FECHNER, Henry
    15926 Luckau (DE)
  • HAZINI, Ahmet
    13353 Berlin (DE)

(74) Representative: Fleuchaus & Gallo Partnerschaft mbB 
Steinerstraße 15/A
81369 München
81369 München (DE)

   


(54) MIR-375- AND MIR-1-REGULATED COXSACKIEVIRUS B3 HAS NO PANCREAS AND HEART TOXICITY BUT STRONG ANTITUMOR EFFICIENCY IN COLORECTAL CARCINOMAS