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(11)

EP 4 247 817 A1

(12)

(43) Date of publication: 27.09.2023 Bulletin 2023/39 (21) Application number: 21843853.9 (22) Date of filing: 17.11.2021

(51) International Patent Classification (IPC):  C07D 498/18(2006.01) C07D 513/22(2006.01) A61P 43/00(2006.01) C07D 498/22(2006.01) A61P 11/00(2006.01) A61K 31/439(2006.01) (52) Cooperative Patent Classification (CPC): C07D 498/22; C07D 498/18; C07D 513/22; A61P 11/00; A61P 43/00 (86) International application number: PCT/US2021/072475 (87) International publication number: WO 2022/109573 (27.05.2022 Gazette 2022/21)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 18.11.2020 US 202063115552 P (71) Applicant: Vertex Pharmaceuticals Incorporated Boston, MA 02210 (US)

(72) Inventors: CLEMENS, Jeremy J. Boston, Massachusetts 02210 (US) BECHARA, William Schulz Boston, Massachusetts 02210 (US) BOOKSER, Brett C. Boston, Massachusetts 02210 (US) CLEVELAND, Thomas Boston, Massachusetts 02210 (US) COON, Timothy Boston, Massachusetts 02210 (US) GALLANT, Michel Boston, Massachusetts 02210 (US) GROOTENHUIS, Peter Diederik Jan (deceased) (US) HADIDA RUAH, Sara Sabina Boston, Massachusetts 02210 (US) LATERREUR, Julie Boston, Massachusetts 02210 (US) MILLER, Mark Thomas Boston, Massachusetts 02210 (US) PARASELLI, Prasuna Boston, Massachusetts 02210 (US) RAMTOHUL, Yeeman K. Boston, Massachusetts 02210 (US) REDDY, Thumkunta Jagadeeswar Boston, Massachusetts 02210 (US) STURINO, Claudio Boston, Massachusetts 02210 (US) VALDEZ, Lino Boston, Massachusetts 02210 (US) ZHOU, Jinglan Boston, Massachusetts 02210 (US) BAEK, Minson Boston, Massachusetts 02210 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)