(19)

(11)

EP 4 255 192 A2

(12)

(88) Date of publication A3: 22.09.2022 (43) Date of publication: 11.10.2023 Bulletin 2023/41 (21) Application number: 21901181.4 (22) Date of filing: 02.12.2021

(51) International Patent Classification (IPC):  A01P 1/00(2006.01) A61K 47/38(2006.01) A61L 27/54(2006.01) C08B 15/00(2006.01) (52) Cooperative Patent Classification (CPC): Y02A 50/30; A61K 9/7007; A61K 47/38 (86) International application number: PCT/TR2021/051334 (87) International publication number: WO 2022/119545 (09.06.2022 Gazette 2022/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.12.2020 TR 202019774 (71) Applicants: Yildiz Teknik Üniversitesi 34220 Istanbul (TR) Saglik Bilimleri Üniversitesi 34668 Uskudar/Istanbul (TR)	(72) Inventors: SAHIN, Yücel Esenler/Istanbul (TR) BÜYÜKKAYHAN, Derya 34668 Uskudar/Istanbul (TR) TÜRKOGLU, Nelisa Esenler/Istanbul (TR) GÜRSU, Hürmüs Esenler/Istanbul (TR) ESENTÜRK, Imren 34668 Üsküdar/Istanbul (TR) (74) Representative: Sevinç, Erkan  Istanbul Patent A.S. Plaza-33, Büyükdere Cad. No: 33/16 Sisli 34381 Istanbul 34381 Istanbul (TR)