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EP 4 255 421 A1

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(43) Date of publication: 11.10.2023 Bulletin 2023/41 (21) Application number: 21816489.5 (22) Date of filing: 01.12.2021

(51) International Patent Classification (IPC):  A61K 31/4045(2006.01) A61P 25/22(2006.01) A61P 25/30(2006.01) A61K 9/12(2006.01) A61P 25/18(2006.01) A61P 25/24(2006.01) C07D 209/16(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/4045; A61P 25/18; A61P 25/22; A61P 25/24; A61P 25/30; A61K 9/0078 (86) International application number: PCT/EP2021/083755 (87) International publication number: WO 2022/117640 (09.06.2022 Gazette 2022/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 01.12.2020 GB 202018950 01.12.2020 GB 202018955 01.12.2020 US 202017108679 01.12.2020 US 202017108938 22.03.2021 GB 202103981 22.03.2021 US 202117208583 23.04.2021 WO PCT/EP2021/060750 13.05.2021 CA 3118556 13.05.2021 WO PCT/EP2021/062794 13.05.2021 GB 202106881 13.05.2021 US 202117320155 18.11.2021 WO PCT/EP2021/082227 18.11.2021 TW 110143066 (71) Applicant: Small Pharma Ltd London EC1Y 8RT (GB)

(72) Inventors: RANDS, Peter London EC2A 4BX (GB) JAMES, Ellen London EC2A 4BX (GB) BENWAY, Tiffanie London EC2A 4BX (GB) JOEL, Zelah London EC2A 4BX (GB) LAYZELL, Marie London EC2A 4BX (GB) (74) Representative: Patent Boutique LLP  10A Printing House Yard Hackney Road London E2 7PR London E2 7PR (GB)