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EP 4 255 575 A2

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(88) Date of publication A3: 11.08.2022 (43) Date of publication: 11.10.2023 Bulletin 2023/41 (21) Application number: 21834759.9 (22) Date of filing: 07.12.2021

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) A61K 39/00(2006.01) A61K 39/395(2006.01) C07K 16/28(2006.01) A61K 31/337(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2827; C07K 16/2878; C07K 2317/75; C07K 2317/73; C07K 2317/52; C07K 2317/24; C07K 2317/31; A61K 2039/505; A61K 2039/507; A61P 35/00; A61K 31/337; A61K 39/39558; A61K 45/06   C-Sets: A61K 31/337, A61K 2300/00; A61K 39/39558, A61K 2300/00; (86) International application number: PCT/EP2021/084659 (87) International publication number: WO 2022/122765 (16.06.2022 Gazette 2022/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.12.2020 US 202063122042 P (71) Applicants: Genmab A/S 1560 Copenhagen V (DK) BioNTech SE 55131 Mainz (DE)

(72) Inventors: SAHIN, Ugur 55131 Mainz (DE) MUIK, Alexander 55131 Mainz (DE) FORSSMANN, Ulf 1560 Copenhagen V (DK) JURE-KUNKEL, Maria Plainsboro, New Jersey 08536 (US) GUPTA, Manish Plainsboro, New Jersey 08536 (US) AHMADI, Tahamtan Plainsboro, New Jersey 08536 (US) AMIRI, Kathy Plainsboro, New Jersey 08536 (US) BAJAJ, Gaurav Plainsboro, New Jersey 08536 (US) (74) Representative: Genmab A/S  Carl Jacobsens Vej 30 2500 Valby 2500 Valby (DK)