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(11)

EP 4 256 046 A1

(12)

(43) Date of publication: 11.10.2023 Bulletin 2023/41 (21) Application number: 21901490.9 (22) Date of filing: 02.12.2021

(51) International Patent Classification (IPC):  C12N 9/22(2006.01) C12N 15/10(2006.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C12N 15/86; C07K 14/005; C12N 2750/14143; C12N 2750/14122; C12N 2310/20; C40B 40/08; C40B 40/02; C12N 15/1086; C12N 15/1089 (86) International application number: PCT/US2021/061682 (87) International publication number: WO 2022/120103 (09.06.2022 Gazette 2022/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 02.12.2020 US 202063120376 P (71) Applicant: The Regents of The University of California Oakland, CA 94607 (US)	(72) Inventors: MALI, Prashant La Jolla, CA 92093 (US) PALMER, Nathan La Jolla, CA 92093 (US) KUMAR, Aditya La Jolla, CA 92093 (US) SUHARDJO, Amanda La Jolla, CA 92093 (US) (74) Representative: Gill Jennings & Every LLP  The Broadgate Tower 20 Primrose Street London EC2A 2ES London EC2A 2ES (GB)