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EP 4 259 796 A1

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(43) Date of publication: 18.10.2023 Bulletin 2023/42 (21) Application number: 21835670.7 (22) Date of filing: 09.12.2021

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61P 25/28(2006.01) A61K 31/7088(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; C12N 2310/11; C12N 2320/33; C12N 2310/315; C12N 2310/3231; C12N 2310/20   C-Sets: C12N 2310/321, C12N 2310/3521; (86) International application number: PCT/EP2021/084908 (87) International publication number: WO 2022/122872 (16.06.2022 Gazette 2022/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.12.2020 GB 202019418 (71) Applicants: UCL Business Ltd London WC1E 6BT (GB) The United States of America, as represented by the Secretary, Department of Health and Human Services Bethesda, MD 20892-7788 (US)

(72) Inventors: FRATTA, Pietro London W1T 4TJ (GB) BROWN, Anna, Leigh London W1T 4TJ (GB) WILKINS, Oscar London W1T 4TJ (GB) KEUSS, Matthew London W1T 4TJ (GB) WARD, Michael Bethesda, MD 20892 7788 (US) HILL, Sarah Bethesda, MD 20892 7788 (US) (74) Representative: Haseltine Lake Kempner LLP  Cheapside House 138 Cheapside London EC2V 6BJ London EC2V 6BJ (GB)