(19)

(11)

EP 4 263 808 A2

(12)

(88) Date of publication A3: 28.07.2022 (43) Date of publication: 25.10.2023 Bulletin 2023/43 (21) Application number: 21865325.1 (22) Date of filing: 16.12.2021

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) A61P 35/00(2006.01) A61K 35/17(2015.01) (52) Cooperative Patent Classification (CPC): C12N 5/0638; C12N 5/0636; C12N 2501/2302; C12N 2510/00; C12N 2501/515; C12N 2500/62; A61K 35/17; C12N 2503/00; A61P 35/00 (86) International application number: PCT/IB2021/000883 (87) International publication number: WO 2022/130017 (23.06.2022 Gazette 2022/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 18.12.2020 US 202063127582 P 18.12.2020 US 202063127639 P 10.12.2021 US 202163288409 P 10.12.2021 US 202163288414 P (71) Applicant: INSTIL BIO (UK) LIMITED Manchester M13 9XX (GB)

(72) Inventors: GUEST, Ryan Manchester M13 9XX (GB) MCCAFFREY, Joanne Manchester M13 9XX (GB) LEGALL, John Dallas TX 752198 (GB) ROBERTS, Zachary Dallas, TX 75219 (US) (74) Representative: Murgitroyd & Company  Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)