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(11)

EP 4 264 269 A1

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(43) Date of publication: 25.10.2023 Bulletin 2023/43 (21) Application number: 21840133.9 (22) Date of filing: 15.12.2021

(51) International Patent Classification (IPC):  G01N 33/543(2006.01) G01N 33/58(2006.01) G01N 33/574(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/54346; G01N 33/57488; G01N 33/587; G01N 33/57407 (86) International application number: PCT/IB2021/061789 (87) International publication number: WO 2022/130251 (23.06.2022 Gazette 2022/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.12.2020 IT 202000031139 (71) Applicant: Università degli Studi di Roma "La Sapienza" 00185 Roma (IT)	(72) Inventors: CARACCIOLO, Giulio 00185 Roma (RM) (IT) DI CARLO, Angelina 00185 Roma (RM) (IT) POZZI, Daniela 00185 Roma (RM) (IT) DIGIACOMO, Luca 00185 Roma (RM) (IT) DI SANTO, Riccardo 00185 Roma (RM) (IT) QUAGLIARINI, Erica 00185 Roma (RM) (IT) (74) Representative: Primiceri, Maria Vittoria et al Praxi Intellectual Property S.p.A. Via Leonida Bissolati, 20 00187 Roma 00187 Roma (IT)