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(11)

EP 4 264 275 A2

(12)

(88) Date of publication A3: 28.07.2022 (43) Date of publication: 25.10.2023 Bulletin 2023/43 (21) Application number: 21844465.1 (22) Date of filing: 15.12.2021

(51) International Patent Classification (IPC):  G01N 33/68(2006.01) C12N 5/0775(2010.01) A61K 35/12(2015.01) A61P 9/00(2006.01) A61K 35/28(2015.01) (52) Cooperative Patent Classification (CPC): G01N 33/6893; G01N 2800/325; G01N 2800/52; A61K 35/28; A61P 9/04 (86) International application number: PCT/US2021/063645 (87) International publication number: WO 2022/132986 (23.06.2022 Gazette 2022/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 15.12.2020 AU 2020904675 12.01.2021 AU 2021900059 10.09.2021 AU 2021902941 20.10.2021 AU 2021903365 (71) Applicant: Mesoblast International Sàrl 1217 Meyrin (CH)

(72) Inventors: ITESCU, Silviu Melbourne, Victoria 3000 (AU) BOROW, Kenneth New York, New York 10017 (US) HAYES, Jack New York, New York 10017 (US) (74) Representative: Thomann, William John  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)