(19)

(11)

EP 4 267 611 A1

(12)

(43) Date of publication: 01.11.2023 Bulletin 2023/44 (21) Application number: 21908157.7 (22) Date of filing: 23.12.2021

(51) International Patent Classification (IPC):  C07K 16/10(2006.01) A61K 39/42(2006.01) A61P 31/14(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/10; A61P 31/14; C07K 2317/76; C07K 2317/92; C07K 2317/34 (86) International application number: PCT/AU2021/051550 (87) International publication number: WO 2022/133545 (30.06.2022 Gazette 2022/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 23.12.2020 AU 2020904813 (71) Applicant: Garvan Institute of Medical Research Darlinghurst, NSW 2010 (AU)	(72) Inventors: MAZIGI, Ohan Petersham, NSW 2049 (AU) LANGLEY, David Marsfield, NSW 2122 (AU) SCHOFIELD, Peter Carlton, NSW 2218 (AU) CHRIST, Daniel Annandale, NSW 2038 (AU) (74) Representative: Lee, Nicholas John et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)