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(11)

EP 4 271 698 A1

(12)

(43) Date of publication: 08.11.2023 Bulletin 2023/45 (21) Application number: 21916103.1 (22) Date of filing: 15.06.2021

(51) International Patent Classification (IPC):  C07K 14/165(2006.01) A61K 38/16(2006.01) A61K 39/215(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/005; C12N 2770/20022; C12N 2770/20034; A61K 38/00; A61K 39/12; A61P 31/14 (86) International application number: PCT/US2021/037341 (87) International publication number: WO 2022/146484 (07.07.2022 Gazette 2022/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 31.12.2020 US 202063132863 P 14.05.2021 US 202163188651 P (71) Applicants: University of Washington Seattle, WA 98105 (US) Fred Hutchinson Cancer Center Seattle, WA 98109-1024 (US)

(72) Inventors: ELLIS, Daniel Seattle, Washington 98105 (US) KING, Neil Seattle, Washington 98105 (US) BLOOM, Jesse Seattle, Washington 98109-1024 (US) STARR, Tyler Seattle, Washington 98109-1024 (US) GREANEY, Allison Seattle, Washington 98109-1024 (US) (74) Representative: Global IP Europe Patentanwaltskanzlei  Pfarrstraße 14 80538 München 80538 München (DE)