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EP 4 271 791 A2

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(88) Date of publication A3: 04.08.2022 (43) Date of publication: 08.11.2023 Bulletin 2023/45 (21) Application number: 21848467.3 (22) Date of filing: 30.12.2021

(51) International Patent Classification (IPC):  C12M 3/00(2006.01) C12M 1/04(2006.01) C12M 1/26(2006.01) A61P 35/00(2006.01) C12M 1/00(2006.01) C12N 5/0783(2010.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C12M 21/08; C12M 23/24; C12M 23/34; C12M 33/14; C12M 47/02; C12N 5/0638; C12N 2501/2302; C12N 2501/515; C12N 2502/11 (86) International application number: PCT/US2021/065610 (87) International publication number: WO 2022/147196 (07.07.2022 Gazette 2022/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 31.12.2020 US 202063132899 P 17.06.2021 US 202163212037 P 30.06.2021 US 202163217244 P 24.11.2021 US 202163282837 P (71) Applicant: Iovance Biotherapeutics, Inc. San Carlos, CA 94070 (US)

(72) Inventors: WELLS, Adrian, Emanual Tampa, FL 33634 (US) GERGES, Nermin, Awad, Samir Orlando, FL 32819 (US) LOVE, Richard, Boyt Berkeley, CA 94708 (US) WYPYCH, Joseph, James Tracy, CA 95376 (US) (74) Representative: Secerna LLP  The Old Fire Station 18 Clifford Street York YO1 9RD York YO1 9RD (GB)