(19)
(11) EP 4 279 064 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
28.02.2024 Bulletin 2024/09

(43) Date of publication A2:
22.11.2023 Bulletin 2023/47

(21) Application number: 23200018.2

(22) Date of filing: 12.05.2016
(51) International Patent Classification (IPC): 
A61F 2/14(2006.01)
A61P 27/02(2006.01)
 A61F 9/00(2006.01)
A61K 9/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/436; A61K 31/404; A61K 31/44; A61K 31/444; A61K 31/496; A61K 31/502; A61K 31/517; A61K 31/56; A61P 27/02; A61P 27/06; A61K 9/0048
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 12.05.2015 US 201562160394 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
16793509.7 / 3294212

(71) Applicant: Incept, LLC
Lexington, MA 02420 (US)

(72) Inventors:
  • JARRETT, Peter
    Lexington, 02420 (US)
  • EL-HAYEK, Rami
    Norwood, 02062 (US)
  • JARRETT, Timothy, S.
    Boston, 02118 (US)
  • BLIZZARD, Charles D.
    Nashua, 03064 (US)
  • SAWHNEY, Amarpreet, S.
    Lexington, 02420 (US)

(74) Representative: dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB 
Deichmannhaus am Dom Bahnhofsvorplatz 1
50667 Köln
50667 Köln (DE)

   


(54) DRUG DELIVERY FROM HYDROGELS


(57) Drug delivery involving hydrogels as used for various medical conditions, and includes hydrogels formed in an eye with extended drug release times. An embodiment of the invention is a method of delivering a therapeutic agent to a tissue comprising forming a hydrogel in situ in an eye with a therapeutic agent dispersed in the hydrogel, the agent having a low solubility in water. The agent may be essentially insoluble in water. The hydrogel may be made so that 50% to 100% w/w of the agent is released when the hydrogel is from 100% to 50% persistent, with the persistence being a measure of the dry weight of the hydrogel relative to an initial dry weight of the hydrogel.







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